{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T04:40:16Z","timestamp":1686804016499},"reference-count":38,"publisher":"Korea Society for Exercise Nutrition","issue":"1","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100002547","name":"Semyung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-pan.org"],"crossmark-restriction":true},"short-container-title":["Phys Act Nutr"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>[Purpose] Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.[Methods] A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (&lt;i&gt;Curcumae longae&lt;\/i&gt; Rhizoma, &lt;i&gt;Schisandrae chinensis&lt;\/i&gt; Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.[Results] MAG (10\u2013100 \u03bcg\/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg\/kg\/d) effectively prevented alcohol-induced gastric mucosal injury &lt;i&gt;in vivo&lt;\/i&gt;.[Conclusion] MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.<\/jats:p>","DOI":"10.20463\/pan.2023.0001","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:38Z","timestamp":1682467238000},"page":"001-008","update-policy":"http:\/\/dx.doi.org\/10.20463\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model"],"prefix":"10.20463","volume":"27","author":[{"given":"Kibong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang 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