{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:02:08Z","timestamp":1789340528260,"version":"build-2803163510"},"reference-count":32,"publisher":"Korea Society for Exercise Nutrition","issue":"4","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100002547","name":"Semyung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-pan.org"],"crossmark-restriction":true},"short-container-title":["Phys Act Nutr"],"published-print":{"date-parts":[[2023,12,31]]},"abstract":"<jats:p>[Purpose] Exercise helps modify the lipid profile in the body, partly through its impact on sterol regulatory element binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3). Individual differences in response to exercise and genetic variations may influence the response to PA. Therefore, this study explored &lt;i&gt;Rosae multiflorae fructus&lt;\/i&gt; (RMF) as a supplement candidate that improves exercise capacity and controls non-alcoholic fatty liver disease (NAFLD) by suppressing lipogenesis and controlling lipid peroxidation.[Methods] RMF is a natural herbal medicine used in Dongui Bogam. RMF has antioxidant, anti-inflammatory, and anti-allergic effects. However, the effects of RMF on NAFLD have not yet been investigated. In this study, we examined the effects of RMF in a mouse model of high-fat diet-induced NAFLD. Mouse livers were isolated and analyzed using H&amp;E staining and immunohistochemistry.[Results] RMF downregulated lipid peroxidation markers, such as CYP2E1, in the livers of mice with high-fat diet-induced NAFLD. Additionally, the RMF significantly reduced the lipid accumulation-related protein expression of CD36, SREBP-1, and PPAR-\u03b3.[Conclusion] RMF exerts anti-lipid peroxidation and anti-lipogenic effects in a high-fat diet-induced NAFLD mouse model.<\/jats:p>","DOI":"10.20463\/pan.2023.0038","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T01:42:11Z","timestamp":1705974131000},"page":"55-59","update-policy":"https:\/\/doi.org\/10.20463\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rosae multiflorae fructus regulates the lipogenesis in high-fat diet-induced NAFLD mice model"],"prefix":"10.20463","volume":"27","author":[{"given":"Kibong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun 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