{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:12:44Z","timestamp":1783649564269,"version":"3.55.0"},"reference-count":54,"publisher":"Korea Society for Exercise Nutrition","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"content-domain":{"domain":["e-pan.org"],"crossmark-restriction":true},"short-container-title":["Phys Act Nutr"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>[Purpose] This meta-analysis examined whether short-term probiotic\/synbiotic supplementation reduces body weight, BMI, fat mass, body fat percentage, and lean body mass in adults with overweight or obesity.[Methods] Electronic databases were searched for RCTs of probiotic or synbiotic interventions versus placebo. Study quality was assessed using the Cochrane Risk-of-Bias tool. Standardized mean differences (Hedges\u2019 g; RevMan 5.4) were pooled using a random-effects model on post-intervention endpoint values.[Results] Ten RCTs (633 participants) were included. No significant differences were observed in body weight (9 studies, &lt;i&gt;n&lt;\/i&gt; = 592; SMD = -0.44; 95% CI: -0.92 to 0.04; I&lt;sup&gt;2&lt;\/sup&gt; = 87%) or lean body mass (5 studies, &lt;i&gt;n&lt;\/i&gt; = 342; SMD = -0.14; 95% CI: \u22120.53 to 0.25; I&lt;sup&gt;2&lt;\/sup&gt; = 69%). A significant reduction in BMI was identified (10 studies, &lt;i&gt;n&lt;\/i&gt; = 633; SMD = -0.50; 95% CI: -0.91 to -0.09; I&lt;sup&gt;2&lt;\/sup&gt; = 84%), and a small but significant effect on fat mass\/body fat percentage was observed (8 studies, &lt;i&gt;n&lt;\/i&gt; = 479; SMD = -0.34; 95% CI: -0.62 to -0.06; I&lt;sup&gt;2&lt;\/sup&gt; = 57%). In sensitivity analyses excluding a study with pre-randomization baseline imbalance, the BMI effect attenuated to borderline significance (SMD = -0.45; &lt;i&gt;p&lt;\/i&gt; = 0.048) and the fat mass\/body fat percentage effect lost statistical significance (SMD = -0.26; &lt;i&gt;p&lt;\/i&gt; = 0.060).[Conclusion] Short-term (8-12 weeks) probiotic\/synbiotic supplementation may yield modest benefits on BMI and adiposity-related outcomes; however, sensitivity analyses indicated these effects were not robust to single-study exclusion. Body weight and lean body mass were not significantly affected. Use of post-intervention endpoint values (change-from-baseline scores were not consistently available) may have biased pooled estimates. Findings should be interpreted as preliminary.<\/jats:p>","DOI":"10.20463\/pan.2026.0025","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:22:32Z","timestamp":1782800552000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.20463\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of probiotics and synbiotics on body weight management in individuals with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.20463","volume":"30","author":[{"given":"Joungbo","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Movement Sciences and Health, Usha Kundu, MD College of Health, University of West Florida, Pensacola, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Chun","sequence":"additional","affiliation":[{"name":"Exercise & Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & 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