{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:12:46Z","timestamp":1783649566378,"version":"3.55.0"},"reference-count":25,"publisher":"Korea Society for Exercise Nutrition","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"content-domain":{"domain":["e-pan.org"],"crossmark-restriction":true},"short-container-title":["Phys Act Nutr"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>[Purpose] This study examined whether regular exercise modulates subcutaneous adipose tissue expression of caveolae-related genes (Cav-1, Cav-2, and Cav-3), insulin signaling mediators (IR, IRS-1, and IRS-2), and sterol regulatory element-binding protein-1c (SREBP-1c) in ovariectomized (OVX) rats.[Methods] Thirty-week-old female Sprague\u2013Dawley rats were ovariectomized and assigned to general diet (OVX-GD), high-fat diet (OVX-H), or high-fat diet plus exercise (OVX-H+EX) groups (&lt;i&gt;n&lt;\/i&gt; = 7). Swimming exercise performed for 60 min\/day, 5 days\/week for 8 weeks. After 12-h fast, inguinal adipose tissue was collected and mRNA expression was analyzed by semi-quantitative RT-PCR. Data were analyzed using one-way ANOVA with Tukey\u2019s post hoc test (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05).[Results] High-fat feeding increased body weight and fat mass compared with the OVX-GD group. Despite no reduction in food intake, exercise attenuated weight gain and reduced final body weight and fat mass (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05). OVX-H rats showed increased Cav-1, Cav-2, and SREBP-1c expression and decreased IR and IRS-1 expression. Exercise reversed these changes. IRS-2 expression was also significantly increased in the exercise group (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05), whereas Cav-3 expression did not differ among the groups.[Conclusion] Regular exercise may improve adipose tissue metabolic regulation in OVX rats by modulating the mRNA expression of caveolae related genes and suppressing lipogenic gene activity.<\/jats:p>","DOI":"10.20463\/pan.2026.0028","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:22:32Z","timestamp":1782800552000},"page":"112-117","update-policy":"https:\/\/doi.org\/10.20463\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of regular swimming exercise on caveolin, insulin signaling, and SREBP-1c in adipose tissue of high-fat-fed ovariectomized rats"],"prefix":"10.20463","volume":"30","author":[{"given":"Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, 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