{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:04:39Z","timestamp":1767045879854},"reference-count":0,"publisher":"OAE Publishing Inc.","issue":"4","content-domain":{"domain":["oaepublish.com"],"crossmark-restriction":false},"short-container-title":["Extracell Vesicles Circ Nucleic Acids"],"abstract":"<jats:p>The activation of CD8+ cytotoxic T-lymphocytes (CTLs) plays the central role in cancer immunotherapy, which depends on the efficient recognition of peptide-major histocompatibility complex (pMHC) by the T cell receptor (TCR) for the first signal, and B7-CD28 co-stimulating for the second signal. To achieve the potent immune stimulatory effect, a genetically engineered cellular membrane nanovesicles platform that integrates antigen self-presentation and immunosuppression reversal (ASPIRE) for cancer immunotherapy was designed. In preclinical mouse models, ASPIRE could markedly improve antigen delivery to lymphoid organs and generate broad-spectrum T-cell responses that eliminate established tumors. This review highlights that the ASPIRE system represents a novel strategy for personalized cancer immunotherapy.<\/jats:p>","DOI":"10.20517\/evcna.2022.35","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T07:51:06Z","timestamp":1665215466000},"page":"301-5","update-policy":"http:\/\/dx.doi.org\/10.20517\/oae.crossmark.policy","source":"Crossref","is-referenced-by-count":3,"title":["Leveraging biomimetic synthesis strategy for next-generation dendritic cell nanovaccines"],"prefix":"10.20517","volume":"3","author":[{"given":"Yutian","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8410","published-online":{"date-parts":[[2022]]},"container-title":["Extracellular Vesicles and Circulating Nucleic Acids"],"original-title":[],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:50:40Z","timestamp":1705567840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oaepublish.com\/articles\/evcna.2022.35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.20517\/evcna.2022.35","relation":{},"ISSN":["2767-6641"],"issn-type":[{"value":"2767-6641","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}