{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:22:24Z","timestamp":1780564944749,"version":"3.54.1"},"reference-count":27,"publisher":"OAE Publishing Inc.","issue":"3","content-domain":{"domain":["oaepublish.com"],"crossmark-restriction":false},"short-container-title":["Extracell Vesicles Circ Nucleic Acids."],"abstract":"<jats:p>In a recent study, Antounians and colleagues (2024) investigated the potential of amniotic fluid stem cell-derived extracellular vesicles (AFSC-EVs) as a therapeutic intervention for pulmonary hypoplasia resulting from congenital diaphragmatic hernia (CDH). They demonstrated the pronounced inflammatory signature of the fetal hypoplastic lungs, marked by heightened macrophage density in a CDH rat model. Intra-amniotic AFSC-EV administration mitigated the inflammatory process and enhanced fetal lung development by promoting branching morphogenesis and epithelial maturation. These findings add to a growing body of preclinical and clinical evidence supporting the therapeutic potential of AFSC-EVs for inflammation-driven pathologies.<\/jats:p>","DOI":"10.20517\/evcna.2025.25","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T03:17:09Z","timestamp":1752117429000},"page":"350-54","update-policy":"https:\/\/doi.org\/10.20517\/oae.crossmark.policy","source":"Crossref","is-referenced-by-count":2,"title":["A new hope for pulmonary hypoplasia: amniotic fluid stem cell extracellular vesicles?"],"prefix":"10.20517","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-5877","authenticated-orcid":true,"given":"Ishara","family":"Atukorala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-3562","authenticated-orcid":true,"given":"Lisa","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8410","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00362-w"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.07.006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/01.aoa.0000816880.71311.e8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5880"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax5941"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szac063"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2168oc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn5405"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05154-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.705676"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.06.024"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c01121"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2021.101502"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.583842"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.09.006"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6450"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90497-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90440-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.256040"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12855"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0467-4"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vesic.2023.100029"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14805"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/biology14030313"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.043"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1484-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szae037"}],"container-title":["Extracellular Vesicles and Circulating Nucleic Acids"],"original-title":[],"link":[{"URL":"https:\/\/www.oaepublish.com\/articles\/evcna.2025.25","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.oaepublish.com\/articles\/evcna.2025.25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T03:17:09Z","timestamp":1752117429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oaepublish.com\/articles\/evcna.2025.25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":27,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.20517\/evcna.2025.25","relation":{},"ISSN":["2767-6641"],"issn-type":[{"value":"2767-6641","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]}}}