{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:31Z","timestamp":1760145631839,"version":"build-2065373602"},"reference-count":0,"publisher":"Forum for Medical Ethics Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJME"],"abstract":"<jats:p>Off-label use of drugs, when not supported by sound scientific evidence, hinders the development of evidence-based medicine and therapeutic innovation, is costly to the healthcare system, and exposes patients to unnecessary risks, including mortality, for an uncertain benefit. Off-label use of baclofen is the preferred pharmacotherapy for alcohol use disorders in India, despite its negative benefit\/harm ratio, and the fact that acamprosate or naltrexone have long been established as robustly evidence-based medicines. This unacceptable state of affairs only illustrates the fact that the marketing strategies of industry cannot be the sole basis for prescribing a drug.<\/jats:p>","DOI":"10.20529\/ijme.2025.044","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:57:22Z","timestamp":1748494642000},"page":"311-312","source":"Crossref","is-referenced-by-count":0,"title":["Off-label use of baclofen for alcohol use disorders in India: no ethics without science"],"prefix":"10.20529","volume":"10","author":[{"given":"Alain","family":"Braillon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8506","published-online":{"date-parts":[[2025,10,10]]},"container-title":["Indian Journal of Medical Ethics"],"original-title":[],"link":[{"URL":"https:\/\/ijme.in\/wp-content\/uploads\/2025\/05\/Off-label-use_315.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:32:24Z","timestamp":1760110344000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijme.in\/articles\/off-label-use-of-baclofen-for-alcohol-use-disorders-in-india-no-ethics-without-science\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,10,10]]}},"URL":"https:\/\/doi.org\/10.20529\/ijme.2025.044","relation":{},"ISSN":["0974-8466","0975-5691"],"issn-type":[{"type":"print","value":"0974-8466"},{"type":"electronic","value":"0975-5691"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}