{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:51:56Z","timestamp":1781211116498,"version":"3.54.1"},"reference-count":0,"publisher":"Socidrogalcohol","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adicciones"],"abstract":"<jats:p>La adolescencia es una etapa de desarrollo cr\u00edtica durante la cual la exposici\u00f3n al estr\u00e9s y al alcohol puede inducir alteraciones neurobiol\u00f3gicas de larga duraci\u00f3n. El consumo de alcohol en atrac\u00f3n es especialmente disruptivo para los circuitos corticoestriatales, sin embargo, a\u00fan se conoce poco sobre hasta qu\u00e9 punto la historia previa de estr\u00e9s modula estos efectos. En este estudio investigamos c\u00f3mo el estr\u00e9s por inmovilizaci\u00f3n, ya sea agudo o repetido, antes de la exposici\u00f3n intermitente al alcohol durante la adolescencia modula los cambios transcripcionales en el estriado dorsal de ratas macho. Los animales fueron expuestos a una sesi\u00f3n \u00fanica (agudo) o a cinco d\u00edas consecutivos (repetido) de estr\u00e9s por inmovilizaci\u00f3n entre los d\u00edas posnatales (DPN) 32\u201336, seguido de cuatro semanas de administraci\u00f3n intermitente intrag\u00e1strica de etanol (3 g\/kg) o soluci\u00f3n salina. En la edad adulta se cuantific\u00f3 la expresi\u00f3n de ARNm estriatal de genes dopamin\u00e9rgicos (Drd1, Drd2, Th), glutamat\u00e9rgicos (Gls, Gls2, Gria2, Grin2a, Grin2b), endocannabinoides (Cnr1, Cnr2, Napepld, Faah, Dagla, Daglb, Mgll), neurotr\u00f3ficos (Bdnf, Ntrk2) y gliales (Gfap, Aif1). La exposici\u00f3n al alcohol increment\u00f3 la expresi\u00f3n de genes asociados con la s\u00edntesis de glutamato y la se\u00f1alizaci\u00f3n de receptores, el metabolismo endocannabinoide y la activaci\u00f3n astroc\u00edtica. El estr\u00e9s agudo amplific\u00f3 la expresi\u00f3n inducida por alcohol de Gls, Gls2, Gria2, Napepld, Faah, Daglb, Ntrk2 y Gfap, mientras que el estr\u00e9s repetido atenu\u00f3 estos efectos y aument\u00f3 selectivamente la expresi\u00f3n de Drd1, Drd2, Grin2a y Bdnf. La activaci\u00f3n microglial (Aif1) se increment\u00f3 por el alcohol independientemente del estr\u00e9s. Estos resultados sugieren que el estr\u00e9s agudo sensibiliza las v\u00edas glutamat\u00e9rgicas y endocannabinoides al alcohol, mientras que el estr\u00e9s repetido activa mecanismos adaptativos consistentes con la hip\u00f3tesis de la inoculaci\u00f3n de estr\u00e9s. En conjunto, el historial de estr\u00e9s determina de manera cr\u00edtica los resultados neurobiol\u00f3gicos de la exposici\u00f3n al alcohol durante la adolescencia, con implicaciones para la resiliencia y la vulnerabilidad a la psicopatolog\u00eda inducida por alcohol.<\/jats:p>","DOI":"10.20882\/adicciones.2483","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:32:09Z","timestamp":1769167929000},"page":"369-382","source":"Crossref","is-referenced-by-count":1,"title":["El historial previo de estr\u00e9s modula los cambios transcripcionales inducidos por alcohol en la adolescencia en las v\u00edas glutamat\u00e9rgicas y endocannabinoides del estriado"],"prefix":"10.20882","volume":"37","author":[{"given":"Laura","family":"Sanchez-Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berke","family":"Canoluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Verheul-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gavito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pavon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Reviriego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8502","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Adicciones"],"original-title":[],"link":[{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/download\/2483\/1654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/download\/2483\/1655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/download\/2483\/1654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:32:09Z","timestamp":1769167929000},"score":1,"resource":{"primary":{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/view\/2483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,23]]}},"URL":"https:\/\/doi.org\/10.20882\/adicciones.2483","relation":{},"ISSN":["0214-4840"],"issn-type":[{"value":"0214-4840","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}