{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:17:34Z","timestamp":1768623454595,"version":"3.49.0"},"reference-count":0,"publisher":"Socidrogalcohol","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adicciones"],"abstract":"<jats:p>La adicci\u00f3n al alcohol se asocia con una elevada comorbilidad psiqui\u00e1trica que complica el tratamiento, siendo necesaria una fenotipaci\u00f3n cl\u00ednica objetiva de estos pacientes para optimizar la atenci\u00f3n y mejorar el pron\u00f3stico. El presente estudio aborda este problema mediante los siguientes objetivos: a) estimar la prevalencia y tipos de comorbilidad psiqui\u00e1trica de una muestra de pacientes que buscan tratamiento por uso de alcohol, b) describir las diferencias de g\u00e9nero en su presentaci\u00f3n y c) analizar los valores plasm\u00e1ticos de 2-acilgliceroles (incluyendo el endocannabinoide 2-araquidonilglicerol), estudiando su posible valor como biomarcador de alcoholismo y\/o comorbilidad psiqui\u00e1trica. Para ello se reclutaron 162 pacientes evaluados con la entrevista semiestructurada PRISM, para evaluar la presencia de comorbilidad y su car\u00e1cter primario o inducido. Los resultados obtenidos indican que la presencia de psicopatolog\u00eda se asoci\u00f3 a un mayor n\u00famero de criterios de abuso y dependencia de alcohol Se encontraron diferencias de g\u00e9nero tanto en la comorbilidad psiqui\u00e1trica, especialmente en trastornos del estado de \u00e1nimo. La prevalencia de comorbilidad psiqui\u00e1trica encontrada a lo largo de la vida fue del 68,5%, destacando los trastornos del estado \u00e1nimo (37%), y seguidos por el trastorno por d\u00e9ficit de atenci\u00f3n (24,7%, monitorizado espec\u00edficamente por la entrevista WURS) y los trastornos de ansiedad (17,9%). Entre los trastornos del estado de \u00e1nimo y psic\u00f3ticos fueron m\u00e1s frecuentes los inducidos, mientras que en los trastornos de ansiedad los primarios fueron m\u00e1s prevalentes. Adem\u00e1s, se encontraron concentraciones disminuidas significativamente de 2-acilgliceroles en pacientes con trastornos de ansiedad com\u00f3rbidos diagnosticados en el \u00faltimo a\u00f1o.<\/jats:p>","DOI":"10.20882\/adicciones.728","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T11:28:18Z","timestamp":1475839698000},"page":"83-96","source":"Crossref","is-referenced-by-count":11,"title":["Comorbilidad psiqui\u00e1trica y valores plasm\u00e1ticos de 2-acilgliceroles en consumidores de alcohol en tratamiento ambulatorio. 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