{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:17:43Z","timestamp":1760404663485,"version":"3.37.3"},"reference-count":0,"publisher":"Socidrogalcohol","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adicciones"],"abstract":"<jats:p>Se presenta el caso de un ni\u00f1o sano de 4 a\u00f1os de edad que ingresa en la sala de hospitalizaci\u00f3n pedi\u00e1trica por la sospecha de una intoxicaci\u00f3n accidental debido a la ingesta de f\u00e1rmacos narcol\u00e9pticos (metilfenidato, sertralina y quetiapina), que tomaba de forma pautada su hermano de 8 a\u00f1os de edad que padec\u00eda un s\u00edndrome de Asperger.La evaluaci\u00f3n objetiva de la intoxicaci\u00f3n se puede realizar con la determinaci\u00f3n de los f\u00e1rmacos y sus metabolitos en matrices biol\u00f3gicas con una ventana de tiempo corta (sangre y orina) o larga (pelo).En el hospital se realiz\u00f3 un an\u00e1lisis de sangre y orina mediante inmunoan\u00e1lisis (confirmado mediante espectrometr\u00eda l\u00edquida-cromatograf\u00eda de masas) y se identific\u00f3 la presencia de sertralina y quetiapina y sus metabolitos. Con la sospecha de administraci\u00f3n cr\u00f3nica de f\u00e1rmacos al ni\u00f1o, se procedi\u00f3 al an\u00e1lisis del pelo con cromatograf\u00eda l\u00edquida de ultra-alto rendimiento-espectrometr\u00eda de masas en t\u00e1ndem. El pelo se dividi\u00f3 en 6 segmentos consecutivos de 2 cm de longitud, de forma que permitieron estudiar la ingesta de los f\u00e1rmacos durante los \u00faltimos 12 meses. En los primeros 4 segmentos se encontr\u00f3 quetiapina con una concentraci\u00f3n media de 1,00 ng\/mg \u00b1 0,94 ng\/mg de pelo y en todos los segmentos se encontraron sertralina y su metabolito, desmetil-sertralina, con una concentraci\u00f3n media de 2,65 \u00b1 0,94 ng\/mg y 1,50 \u00b1 0,94 ng\/mg de pelo, respectivamente. El an\u00e1lisis de pelo result\u00f3 negativo para metilfenidato y su metabolito (\u00e1cido rital\u00ednico).La detecci\u00f3n en matrices biol\u00f3gicas de f\u00e1rmacos psicoactivos demostr\u00f3 la intoxicaci\u00f3n aguda y cr\u00f3nica por quetiapina y sertralina, administradas por la madre.<\/jats:p>","DOI":"10.20882\/adicciones.825","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T17:01:26Z","timestamp":1466614886000},"page":"158-162","source":"Crossref","is-referenced-by-count":17,"title":["An\u00e1lisis segmentario del pelo para detectar la exposici\u00f3n cr\u00f3nica a drogas psicoactivas"],"prefix":"10.20882","volume":"28","author":[{"given":"Emilia","family":"Marchei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Palmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Pichini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Pacifici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileana-Rita","family":"Anton Airaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Costa Orvay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Garc\u00eda Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolom\u00e9","family":"Bonet Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3scar","family":"Garc\u00eda-Algar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8502","published-online":{"date-parts":[[2016,6,15]]},"container-title":["Adicciones"],"original-title":[],"link":[{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/download\/825\/781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/download\/825\/780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:26:03Z","timestamp":1740054363000},"score":1,"resource":{"primary":{"URL":"https:\/\/adicciones.es\/index.php\/adicciones\/article\/view\/825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,6,17]]}},"URL":"https:\/\/doi.org\/10.20882\/adicciones.825","relation":{},"ISSN":["0214-4840"],"issn-type":[{"type":"print","value":"0214-4840"}],"subject":[],"published":{"date-parts":[[2016,6,15]]}}}