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Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: Methodology and effect sizes. Am J Psychiatry. 2011;168(5):472-85. doi: 10.1176\/appi.ajp.2010.10060855","DOI":"10.1176\/appi.ajp.2010.10060855"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"16. Wykes T, Spaulding WD. Thinking about the future cognitive remediation therapy-what works and could we do better? Schizophr Bull. 2011;37(Suppl 2):S80-90. doi: 10.1093\/schbul\/sbr064","DOI":"10.1093\/schbul\/sbr064"},{"key":"ref17","unstructured":"17. Mahncke H, Kim SJ, Stasio C, Walker T, Buckley P, Caroff S. Results of an FDA device clearance trial for plasticity-based adaptive cognitive remediation (PACR). 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Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects. Sports Med. 2010;40(9):765-801. doi: 10.2165\/11534530-000000000-00000","DOI":"10.2165\/11534530-000000000-00000"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0079-6123(08)64007-8","article-title":"Chapter 6 Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity","volume":"117","author":"Castr\u00e9n","year":"1998","unstructured":"26. Castr\u00e9n E, Berninger B, Leing\u00e4rtner A, Lindholm D. Chapter 6 Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity. 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Psychiatry Res. 2015;226(1):1-13. doi: 10.1016\/j.psychres.2014.12.069","DOI":"10.1016\/j.psychres.2014.12.069"},{"issue":"2","key":"ref32","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/ddrr.64","article-title":"Plasticity in the developing brain: implications for rehabilitation","volume":"15","author":"Johnston","year":"2009","unstructured":"32. Johnston MV. Plasticity in the developing brain: implications for rehabilitation. Dev Disabil Res Rev. 2009;15(2):94-101.","journal-title":"Dev Disabil Res Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bbi.2012.10.021","article-title":"Neurobiological markers of exercise-related brain plasticity in older adults","volume":"28","author":"Voss","year":"2013","unstructured":"33. Voss MW, Erickson KI, Prakash RS, Chaddock L, Kim JS, Alves H, et al. Neurobiological markers of exercise-related brain plasticity in older adults. 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Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, et al. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009;94(10):1062-9. doi: 10.1113\/expphysiol.","DOI":"10.1113\/expphysiol.2009.048512"},{"key":"ref37","unstructured":"2009.048512"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"37. Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298(2):R372-7. doi: 10.1152\/ajpregu.00525.2009","DOI":"10.1152\/ajpregu.00525.2009"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpsychires.2014.10.003","article-title":"A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor","volume":"60","author":"Szuhany","year":"2015","unstructured":"38. Szuhany KL, Bugatti M, Otto MW. 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Voss MW, Heo S, Prakash RS, Erickson KI, Alves H, Chaddock L, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp. 2013;34(11):2972-85. doi: 10.1002\/hbm.22119","DOI":"10.1002\/hbm.22119"},{"issue":"13","key":"ref58","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1073\/pnas.0611721104","article-title":"An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus","volume":"104","author":"Pereira","year":"2007","unstructured":"57. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007;104(13):5638-43.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"58. Kandola A, Hendrikse J, Lucassen PJ, Y\u00fccel M. 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CNS Neurol Disord Drug Targets. 2017;16(6):638-51. doi: 10.2174\/1871527315666161223142918","DOI":"10.2174\/1871527315666161223142918"},{"issue":"4","key":"ref62","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3109\/09638237.2015.1036974","article-title":"Aerobic capacity is associated with global functioning in people with schizophrenia","volume":"24","author":"Vancampfort","year":"2015","unstructured":"61. Vancampfort D, Guelinckx H, Probst M, Ward PB, Rosenbaum S, Stubbs B, et al. Aerobic capacity is associated with global functioning in people with schizophrenia. J Ment Health. 2015;24(4):214-8.","journal-title":"J Ment Health"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"62. Strassnig M, Brar JS, Ganguli R. Low cardiorespiratory fitness and physical functional capacity in obese patients with schizophrenia. 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Scheewe TW, van Haren NE, Sarkisyan G, Schnack HG, Brouwer RM, de Glint M, et al. Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls. Eur Neuropsychopharmacol. 2013;23(7):675-85.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"7","key":"ref66","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1017\/S0033291714003110","article-title":"A systematic review and meta-analysis of exercise interventions in schizophrenia patients","volume":"45","author":"Firth","year":"2015","unstructured":"65. Firth J, Cotter J, Elliott R, French P, Yung AR. A systematic review and meta-analysis of exercise interventions in schizophrenia patients. Psychol Med. 2015;45(7):1343-61.","journal-title":"Psychol Med"},{"issue":"3","key":"ref67","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/acps.12350","article-title":"Aerobic exercise capacity: an important correlate of psychosocial function in first episode psychosis","volume":"131","author":"Rosenbaum","year":"2015","unstructured":"66. Rosenbaum S, Watkins A, Teasdale S, Curtis J, Samaras K, Kalucy M, et al. Aerobic exercise capacity: an important correlate of psychosocial function in first episode psychosis. Acta Psychiatr Scand. 2015;131(3):234.","journal-title":"Acta Psychiatr Scand"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"67. Gorczynski P, Faulkner G. Exercise therapy for schizophrenia. Cochrane Database Syst Rev. 2010;(5):CD004412.","DOI":"10.1002\/14651858.CD004412.pub2"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"68. Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: A systematic review and meta-analysis. Schizophr Bull. 2017;43(3):546-56. doi: 10.1093\/schbul\/sbw115","DOI":"10.1093\/schbul\/sbw115"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"69. Firth J, Carney R, Elliott R, French P, Parker S, McIntyre R, et al. Exercise as an intervention for first-episode psychosis: a feasibility study. Early Interv Psychiatry. 2018;12(3):307-15. doi: 10.1111\/eip.12329","DOI":"10.1111\/eip.12329"},{"issue":"3","key":"ref71","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1600-0447.2007.01032.x","article-title":"Yoga therapy as an add-on treatment in the management of patients with schizophrenia-A randomized controlled trial","volume":"116","author":"Duraiswamy","year":"2007","unstructured":"70. Duraiswamy G, Thirthalli J, Nagendra HR, Gangadhar BN. 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Schizophr Res. 2013;150(2-3):538-41. doi: 10.1016\/j.schres.2013.08.034","DOI":"10.1016\/j.schres.2013.08.034"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"73. Rosenbaum S, Tiedemann A, Sherrington C, Curtis J, Ward PB. Physical activity interventions for people with mental illness: A systematic review and meta-analysis. J Clin Psychiatry. 2014;75(9):964-74. doi: 10.4088\/JCP.13r08765","DOI":"10.4088\/JCP.13r08765"},{"issue":"4","key":"ref75","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1093\/schbul\/sbv022","article-title":"The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial","volume":"41","author":"Kimhy","year":"2015","unstructured":"74. Kimhy D, Vakhrusheva J, Bartels MN, Armstrong HF, Ballon JS, Khan S, et al. The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial. Schizophr Bull. 2015;41(4):859-68.","journal-title":"Schizophr Bull"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"75. Vancampfort D, Rosenbaum S, Probst M, Soundy A, Mitchell AJ, De Hert M, et al. Promotion of cardiorespiratory fitness in schizophrenia: a clinical overview and meta-analysis. Acta Psychiatr Scand. 2015;132(2):131-43. doi: 10.1111\/acps.12407","DOI":"10.1111\/acps.12407"},{"issue":"5","key":"ref77","doi-asserted-by":"publisher","first-page":"921","DOI":"10.2105\/AJPH.2007.133165","article-title":"The effect of aerobic training and cardiac autonomic regulation in young adults","volume":"99","author":"Sloan","year":"2009","unstructured":"76. Sloan RP, Shapiro PA, DeMeersman RE, Bagiella E, Brondolo EN, McKinley PS, et al. The effect of aerobic training and cardiac autonomic regulation in young adults. Am J Public Health. 2009;99(5):921-8.","journal-title":"Am J Public Health"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"77. Armstrong HF, Bartels MN, Paslavski O, Cain D, Shoval HA, Ballon JS, et al. The impact of aerobic exercise training on cardiopulmonary functioning in individuals with schizophrenia. Schizophr Res. 2016;173(1-2):116-7.","DOI":"10.1016\/j.schres.2016.03.009"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"78. Kimhy D, Lauriola V, Bartels MN, Armstrong HF, Vakhrusheva J, Ballon JS, et al. Aerobic exercise for cognitive deficits in schizophrenia-The impact of frequency, duration, and fidelity with target training intensity. Schizophr Res. 2016;172(1-3):213-5.","DOI":"10.1016\/j.schres.2016.01.055"},{"issue":"2","key":"ref80","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1176\/appi.ps.201400523","article-title":"Use of Active-Play Video Games to Enhance Aerobic Fitness in Schizophrenia: Feasibility, Safety, and Adherence","volume":"67","author":"Kimhy","year":"2016","unstructured":"79. Kimhy D, Khan S, Ayanrouh L, Chang RW, Hansen MC, Lister A, et al. Use of Active-Play Video Games to Enhance Aerobic Fitness in Schizophrenia: Feasibility, Safety, and Adherence. Psychiatr Serv. 2016;67(2):240-3.","journal-title":"Psychiatr Serv"},{"issue":"3","key":"ref81","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-2753.2009.01188.x","article-title":"Exercise parameters in the treatment of clinical depression: a systematic review of randomized controlled trials","volume":"16","author":"Perraton","year":"2010","unstructured":"80. Perraton LG, Kumar S, Machotka Z. Exercise parameters in the treatment of clinical depression: a systematic review of randomized controlled trials. J Eval Clin Pr. 2010;16(3):597-604.","journal-title":"J Eval Clin Pr"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"81. Morgan MA, Coates MJ, Dunbar JA, Reddy P, Schlicht K, Fuller J. The TrueBlue model of collaborative care using practice nurses as case managers for depression alongside diabetes or heart disease: a randomised trial. BMJ Open. 2013;3(1). doi: 10.1136\/bmjopen-2012-002171","DOI":"10.1136\/bmjopen-2012-002171"},{"issue":"21","key":"ref83","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1161\/CIR.0b013e318219661d","article-title":"The power of play: Innovations in Getting Active Summit 2011: a science panel proceedings report from the American Heart Association","volume":"123","author":"Lieberman","year":"2011","unstructured":"82. Lieberman DA, Chamberlin B, Medina Jr. E, Franklin BA, Sanner BM, Vafiadis DK, et al. The power of play: Innovations in Getting Active Summit 2011: a science panel proceedings report from the American Heart Association. Circulation. 2011;123(21):2507-16.","journal-title":"Circulation"},{"issue":"6","key":"ref84","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jpeds.2009.01.009","article-title":"Activity-promoting video games and increased energy expenditure","volume":"154","author":"Lanningham-Foster","year":"2009","unstructured":"83. Lanningham-Foster L, Foster RC, McCrady SK, Jensen TB, Mitre N, Levine JA. Activity-promoting video games and increased energy expenditure. J Pediatr. 2009;154(6):819-23.","journal-title":"J Pediatr"},{"issue":"3","key":"ref85","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1123\/jpah.7.3.393","article-title":"The physiological cost and enjoyment of Wii Fit in adolescents, young adults, and older adults","volume":"7","author":"Graves","year":"2010","unstructured":"84. Graves LE, Ridgers ND, Williams K, Stratton G, Atkinson G, Cable NT. The physiological cost and enjoyment of Wii Fit in adolescents, young adults, and older adults. J Phys Act Health. 2010;7(3):393-401.","journal-title":"J Phys Act Health"},{"key":"ref86","unstructured":"85. Guderian B, Borreson LA, Sletten LE, Cable K, Stecker TP, Probst MA, et al. The cardiovascular and metabolic responses to Wii Fit video game playing in middle-aged and older adults. J Sports Med Phys Fit. 2010;50(4):436-42."},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"86. Miyachi M, Yamamoto K, Ohkawara K, Tanaka S. METs in adults while playing active video games: a metabolic chamber study. Med Sci Sports Exerc. 2010;42(6):1149-53.","DOI":"10.1249\/MSS.0b013e3181c51c78"},{"key":"ref88","unstructured":"87. Karvonen MJ, Kentala E, Mustala O. The effects of training on heart rate; a longitudinal study. Ann Med Exp Biol Fenn. 1957;35(3):307-15."},{"key":"ref89","doi-asserted-by":"publisher","unstructured":"88. Ory M, Resnick B, Jordan PJ, Coday M, Riebe D, Ewing Garber C, et al. Screening, safety, and adverse events in physical activity interventions: collaborative experiences from the behavior change consortium. Ann Behav Med. 2005;29(Suppl):20-8.","DOI":"10.1207\/s15324796abm2902s_5"},{"issue":"7","key":"ref90","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise","volume":"43","author":"Garber","year":"2011","unstructured":"89. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334-59.","journal-title":"Med Sci Sports Exerc"},{"key":"ref91","doi-asserted-by":"publisher","unstructured":"90. Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, et al. The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity. Am J Psychiatry. 2008;165(2):203-13. doi: 10.1176\/appi.ajp.2007.07010042","DOI":"10.1176\/appi.ajp.2007.07010042"},{"key":"ref92","doi-asserted-by":"publisher","unstructured":"91. Fisher M, Holland C, Subramaniam K, Vinogradov S. Neuroplasticity-based cognitive training in schizophrenia: An interim report on the effects 6 months later. Schizophr Bull. 2010;36(4):869-79. doi: 10.1093\/schbul\/sbn170","DOI":"10.1093\/schbul\/sbn170"},{"key":"ref93","doi-asserted-by":"publisher","unstructured":"92. Kern RS, Gold JM, Dickinson D, Green MF, Nuechterlein KH, Baade LE, et al. The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study. Schizophr Res. 2011 Mar;126(1-3):124-31. doi: 10.1016\/j.schres.2010.11.008","DOI":"10.1016\/j.schres.2010.11.008"},{"key":"ref94","doi-asserted-by":"publisher","unstructured":"93. Hufford MR, Davis VG, Hilt D, Dgetluck N, Geffen Y, Loebel A, et al. Circadian rhythms in cognitive functioning among patients with schizophrenia: Impact on signal detection in clinical trials of potential pro-cognitive therapies. Schizophr Res. 2014 Oct;159(1):205-10. doi: 10.1016\/j.schres.2014.07.018","DOI":"10.1016\/j.schres.2014.07.018"},{"key":"ref95","unstructured":"94. Borg G. Borgs perceived exertion and pain scales. Champaign (US): Human Kinetics; 1998."},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"95. Schneider LC, Struening EL. SLOF: a behavioral rating scale for assessing the mentally ill. Soc Work Res Abstr. 1983 Fall;19(3):9-21.","DOI":"10.1093\/swra\/19.3.9"},{"key":"ref97","unstructured":"96. Harvey PD. Assessment of everyday functioning in schizophrenia. Innov Clin Neurosci. 2011;8(5):21-4."},{"key":"ref98","doi-asserted-by":"publisher","unstructured":"97. Harvey PD, Ogasa M, Cucchiaro J, Loebel A, Keefe RSE. Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone. Schizophr Res. 2011;127(1-3):188-94. doi: 10.1016\/j.schres.2011.01.004","DOI":"10.1016\/j.schres.2011.01.004"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"98. Harvey PD, Raykov T, Twamley EW, Vella L, Heaton RK, Patterson TL. Validating the measurement of real-world functional outcomes: Phase I results of the VALERO study. Am J Psychiatry. 2011;168(11):1195-201. doi: 10.1176\/appi.ajp.2011.10121723","DOI":"10.1176\/appi.ajp.2011.10121723"},{"issue":"2","key":"ref100","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/oxfordjournals.schbul.a006870","article-title":"UCSD Performance-Based Skills Assessment: Development of a New Measure of Everyday Functioning for Severely Mentally Ill Adults","volume":"27","author":"Patterson","year":"2001","unstructured":"99. Patterson TL, Goldman S, McKibbin CL, Hughs T, Jeste DV. UCSD Performance-Based Skills Assessment: Development of a New Measure of Everyday Functioning for Severely Mentally Ill Adults. Schizophr Bull. 2001;27(2):235-45.","journal-title":"Schizophr Bull"},{"issue":"3","key":"ref101","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1176\/appi.ajp.163.3.426","article-title":"The schizophrenia cognition rating scale: An interview-based assessment and its relationship to cognition, real-world functioning, and functional capacity","volume":"163","author":"Keefe","year":"2006","unstructured":"100. Keefe RSE, Poe M, Walker TM, Kang JW, Harvey PD. The schizophrenia cognition rating scale: An interview-based assessment and its relationship to cognition, real-world functioning, and functional capacity. Am J Psychiatry. 2006;163(3):426-32.","journal-title":"Am J Psychiatry"},{"issue":"4","key":"ref102","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.jpsychires.2006.12.008","article-title":"Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia","volume":"42","author":"Mausbach","year":"2008","unstructured":"101. Mausbach BT, Bowie CR, Harvey PD, Twamley EW, Goldman SR, Jeste DV, et al. Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia. J Psychiatr Res. 2008;42(4):320-7.","journal-title":"J Psychiatr Res"},{"issue":"2","key":"ref103","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/schbul\/sbn152","article-title":"A Review of instruments for measuring functional recovery in those diagnosed with psychosis","volume":"35","author":"Mausbach","year":"2009","unstructured":"102. Mausbach BT, Moore R, Bowie C, Cardenas V, Patterson TL. A Review of instruments for measuring functional recovery in those diagnosed with psychosis. Schizophr Bull. 2009;35(2):307-18.","journal-title":"Schizophr Bull"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"103. Elliott CS, Fiszdon JM. Comparison of self-report and performance-based measures of everyday functioning in individuals with schizophrenia: Implications for measure selection. Cogn Neuropsychiatry. 2014;19(6):485-94. doi: 10.1080\/13546805.2014.922062","DOI":"10.1080\/13546805.2014.922062"},{"key":"ref105","doi-asserted-by":"publisher","unstructured":"104. Keefe RSE, Meltzer HA, Dgetluck N, Gawryl M, Koenig G, Moebius HJ, et al. Randomized, Double-Blind, Placebo-controlled study of encenicline, an \u03b17 nicotinic acetylcholine receptor agonist, as a treatment for cognitive impairment in schizophrenia. Neuropsychopharmacology. 2015;40(13):3053-60. doi: 10.1038\/npp.2015.176","DOI":"10.1038\/npp.2015.176"},{"key":"ref106","doi-asserted-by":"publisher","unstructured":"105. Keefe RSE, Davis VG, Spagnola NB, Hilt D, Dgetluck N, Ruse S, et al. Reliability, validity and treatment sensitivity of the Schizophrenia Cognition Rating Scale. Eur Neuropsychopharmacol. 2015;25(2):176-84. doi: 10.1016\/j.euroneuro.","DOI":"10.1016\/j.euroneuro.2014.06.009"},{"key":"ref107","unstructured":"2014.06.009"},{"key":"ref108","doi-asserted-by":"publisher","unstructured":"106. Vita A, Deste G, Barlati S, De Peri L, Giambra A, Poli R, et al. Interview-based assessment of cognition in schizophrenia: Applicability of the Schizophrenia Cognition Rating Scale (SCoRS) in different phases of illness and settings of care. Schizophr Res. 2013;146(1-3):217-23. doi: 10.1016\/j.schres.2013.02.035","DOI":"10.1016\/j.schres.2013.02.035"},{"issue":"3","key":"ref109","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2144\/000114204","article-title":"Influence of clotting duration on brain-derived neurotrophic factor (BDNF) dosage in serum","volume":"57","author":"Maffioletti","year":"2014","unstructured":"107. Maffioletti E, Zanardini R, Gennarelli M, Bocchio-Chiavetto L. Influence of clotting duration on brain-derived neurotrophic factor (BDNF) dosage in serum. Biotechniques. 2014;57(3):111-4.","journal-title":"Biotechniques"},{"key":"ref110","unstructured":"108. First MB, Gibbon M. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II). Comprehensive Handbook of Psychological Assessment, Personality Assessment. In: Hilsenroth MJ, Segal DL, editors. Comprehensive handbook of psychological assessment. Vol. 2. Personality assessment. Hoboken(US): John Wiley & Sons Inc.; 2004. p. 134-43."},{"issue":"2","key":"ref111","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","unstructured":"109. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-76.","journal-title":"Schizophr Bull"},{"key":"ref112","doi-asserted-by":"publisher","unstructured":"110. Beck AT, Steer RA, Brown GK. Manual for the Beck depression inventory-II. New York (US): San Antonio TX Psychol Corp; 1996.","DOI":"10.1037\/t00742-000"},{"issue":"8","key":"ref113","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","unstructured":"111. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-95.","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"ref114","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1249\/MSS.0b013e318206476e","article-title":"Comparison of accelerometer cut points for predicting activity intensity in youth","volume":"43","author":"Trost","year":"2011","unstructured":"112. Trost SG, Loprinzi PD, Moore R, Pfeiffer KA. Comparison of accelerometer cut points for predicting activity intensity in youth. Med Sci Sports Exerc. 2011;43(7):1360-8.","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"ref115","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","unstructured":"113. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213.","journal-title":"Psychiatry Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"425826","DOI":"10.1155\/2013\/425826","article-title":"Sleep, fatigue, and functional health in psychotic patients","volume":"2013","author":"Waters","year":"2013","unstructured":"114. Waters F, Naik N, Rock D. Sleep, fatigue, and functional health in psychotic patients. Schizophr Res Treat. 2013;2013:425826.","journal-title":"Schizophr Res Treat"},{"issue":"7","key":"ref117","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3109\/15622975.2012.756987","article-title":"Sleep-wake patterns in schizophrenia patients compared to healthy controls","volume":"15","author":"Afonso","year":"2014","unstructured":"115. Afonso P, Figueira ML, Paiva T. Sleep-wake patterns in schizophrenia patients compared to healthy controls. World J Biol Psychiatry. 2014;15(7):517-24.","journal-title":"World J Biol Psychiatry"},{"issue":"1","key":"ref118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2869.2003.00337.x","article-title":"Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study","volume":"12","author":"Belenky","year":"2003","unstructured":"116. Belenky G, Wesensten NJ, Thorne DR, Thomas ML, Sing HC, Redmond DP, et al. Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res. 2003;12(1):1-12.","journal-title":"J Sleep Res"},{"issue":"9","key":"ref119","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/j.1360-0443.1991.tb01879.x","article-title":"The Fagerstr\u00f6m Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire","volume":"86","author":"Heatherton","year":"1991","unstructured":"117. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom K\u2010O. The Fagerstr\u00f6m Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict. 1991;86(9):1119-27.","journal-title":"Br J Addict"},{"issue":"6","key":"ref120","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/clpt.1982.233","article-title":"Circadian blood nicotine concentrations during cigarette smoking","volume":"32","author":"Benowitz","year":"1982","unstructured":"118. Benowitz NL, Kuyt F, Jacob P III. Circadian blood nicotine concentrations during cigarette smoking. Clin Pharmacol Ther. 1982;32(6):758-64.","journal-title":"Clin Pharmacol Ther"},{"key":"ref121","unstructured":"119. Benowitz NL, Jacob P III, Jones RT, Rosenberg J. Interindividual variability in the metabolism and cardiovascular effects of nicotine in man. J Pharmacol Exp Ther. 1982;221(2):368-72."},{"issue":"4","key":"ref122","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1176\/appi.ajp.2010.10040569","article-title":"Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: a double-blind, randomized, placebo-controlled study","volume":"168","author":"Allen","year":"2011","unstructured":"120. Allen MH, Debanne M, Lazignac C, Adam E, Dickinson LM, Damsa C. Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry. 2011;168(4):395-9.","journal-title":"Am J Psychiatry"},{"key":"ref123","unstructured":"121. Beck AT, Steer RA. Beck Anxiety Inventory Manual. In: Kreutzer JS, DeLuca J, Caplan B, editors. Encyclopedia of Clinical Neuropsychology. New York (US): Springer; 1990."},{"issue":"1","key":"ref124","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0022-3999(94)90005-1","article-title":"Item selection and cross-validation of the factor structure","volume":"38","author":"Bagby","year":"1994","unstructured":"122. Bagby RM, Parker JDA, Taylor GJ. The twenty-item Toronto Alexithymia scale-I. Item selection and cross-validation of the factor structure. J Psychosom Res. 1994;38(1):23-32.","journal-title":"J Psychosom Res"},{"issue":"2","key":"ref125","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1037\/0022-3514.85.2.348","article-title":"Individual Differences in Two Emotion Regulation Processes: Implications for Affect, Relationships, and Well-Being","volume":"85","author":"JJ","year":"2003","unstructured":"123. Gross JJ, John OP. Individual Differences in Two Emotion Regulation Processes: Implications for Affect, Relationships, and Well-Being. J Pers Soc Psychol. 2003;85(2):348-62.","journal-title":"J Pers Soc Psychol"},{"key":"ref126","doi-asserted-by":"publisher","unstructured":"124. Giles GE, Cantelon JA, Eddy MD, Bruny\u00e9 TT, Urry HL, Mahoney CR, et al. Habitual exercise is associated with cognitive control and cognitive reappraisal success. Exp Brain Res. 2017;235(12):3785-97. doi: 10.1007\/s00221-017-5098-x","DOI":"10.1007\/s00221-017-5098-x"},{"key":"ref127","doi-asserted-by":"publisher","unstructured":"125. Kimhy D, Vakhrusheva J, Jobson-Ahmed L, Tarrier N, Malaspina D, Gross JJ. Emotion awareness and regulation in individuals with schizophrenia: Implications for social functioning. Psychiatry Res. 2012;200(2-3):193-201. doi: 10.1016\/j.psychres.2012.05.029","DOI":"10.1016\/j.psychres.2012.05.029"},{"issue":"1","key":"ref128","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1207\/s15327752jpa4901_13","article-title":"The Satisfaction With Life Scale","volume":"49","author":"Diener","year":"1985","unstructured":"126. Diener E, Emmons RA, Larsem RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985;49(1):71-5.","journal-title":"J Pers Assess"},{"key":"ref129","doi-asserted-by":"publisher","unstructured":"127. Wu CH, Wu CY. Life satisfaction in persons with schizophrenia living in the community. Validation of the satisfaction with life scale. Soc Indic Res. 2008;85(3):447-60. https:\/\/doi.org\/10.1007\/s11205-007-9136-0","DOI":"10.1007\/s11205-007-9136-0"},{"issue":"3","key":"ref130","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1097\/00004583-199703000-00012","article-title":"Validity of the childhood trauma questionnaire in an adolescent psychiatric population","volume":"36","author":"Bernstein","year":"1997","unstructured":"128. Bernstein DP, Ahluvalia T, Pogge D, Handelsman L. Validity of the childhood trauma questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry. 1997;36(3):340-8.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref131","doi-asserted-by":"publisher","unstructured":"129. Mondelli V, Cattaneo A, Murri MB, Forti M Di, Handley R, Hepgul N, et al. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: A pathway to smaller hippocampal volume. J Clin Psychiatry. 2011;72(12):1677-84. doi: 10.4088\/JCP.10m06745","DOI":"10.4088\/JCP.10m06745"},{"key":"ref132","doi-asserted-by":"publisher","unstructured":"130. Guy W. ECDEU Assessment Manual for Psychopharmacology: Revised. Rockville (US): National Institute of Mental Health; 1976. p. 76-338.","DOI":"10.1037\/e591322011-001"},{"key":"ref133","unstructured":"131. Wechsler D. Wechsler Test of Adult Reading: WTAR. New York (US): Psychological Corporation; 2001."},{"key":"ref134","doi-asserted-by":"publisher","unstructured":"132. August SM, Kiwanuka JN, McMahon RP, Gold JM. The MATRICS Consensus Cognitive Battery (MCCB): Clinical and cognitive correlates. Schizophr Res. 2012;134(1):76-82. doi: 10.1016\/j.schres.2011.10.015","DOI":"10.1016\/j.schres.2011.10.015"},{"issue":"2","key":"ref135","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jagp.2012.10.011","article-title":"Cognitive performance of individuals with schizophrenia across seven decades: A study using the MATRICS consensus cognitive battery","volume":"21","author":"Rajji","year":"2013","unstructured":"133. Rajji TK, Voineskos AN, Butters MA, Miranda D, Arenovich T, Menon M, et al. Cognitive performance of individuals with schizophrenia across seven decades: A study using the MATRICS consensus cognitive battery. Am J Geriatr Psychiatry. 2013;21(2):108-18.","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref136","doi-asserted-by":"publisher","unstructured":"134. McEvoy JP, Byerly M, Hamer RM, Dominik R, Swartz MS, Rosenheck RA, et al. Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: A randomized clinical trial. JAMA. 2014;311(19):1978-87. doi: 10.1001\/jama.2014.4310","DOI":"10.1001\/jama.2014.4310"},{"key":"ref137","doi-asserted-by":"publisher","unstructured":"135. Kogan S, Ospina LH, Kimhy D. Inflammation in individuals with schizophrenia - Implications for neurocognition and daily function. Brain Behav Immun. 2018;74:296-9. doi: 10.1016\/j.bbi.2018.09.016","DOI":"10.1016\/j.bbi.2018.09.016"},{"key":"ref138","doi-asserted-by":"publisher","unstructured":"136. Kogan S, Ospina LH, Mittal VA, Kimhy D. The impact of inflammation on neurocognition and risk for psychosis: a critical review. Eur Arch Psychiatry Clin Neurosci. 2019. doi: 10.1007\/s00406-019-01073-2","DOI":"10.1007\/s00406-019-01073-2"},{"key":"ref139","unstructured":"137. Muth\u00e9n LK, Muth\u00e9n BO. Mplus User's Guide. Eighth Edition. Los Angel (US): Muth\u00e9n Muth\u00e9n; 2017."},{"key":"ref140","doi-asserted-by":"publisher","unstructured":"138. Strassnig MT, Signorile JF, Potiaumpai M, Romero MA, Gonzalez C, Czaja S, et al. High velocity circuit resistance training improves cognition, psychiatric symptoms and neuromuscular performance in overweight outpatients with severe mental illness. Psychiatry Res. 2015;229(1-2):295-301. doi: 10.1016\/j.psychres.2015.07.007","DOI":"10.1016\/j.psychres.2015.07.007"},{"issue":"0","key":"ref141","doi-asserted-by":"publisher","first-page":"15047","DOI":"10.1038\/npjschz.2015.47","article-title":"Aerobic exercise and yoga improve neurocognitive function in women with early psychosis","volume":"1","author":"Lin","year":"2015","unstructured":"139. Lin J, Chan SK, Lee EH, Chang WC, Tse M, Su WW, et al. Aerobic exercise and yoga improve neurocognitive function in women with early psychosis. NPJ Schizophr. 2015;1(0):15047.","journal-title":"NPJ Schizophr"},{"key":"ref142","doi-asserted-by":"publisher","unstructured":"140. Oertel-Kn\u00f6chel V, Mehler P, Thiel C, Steinbrecher K, Malchow B, Tesky V, et al. Effects of aerobic exercise on cognitive performance and individual psychopathology in depressive and schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2014;264(7):589-604. doi: 10.1007\/s00406-014-0485-9","DOI":"10.1007\/s00406-014-0485-9"},{"key":"ref143","doi-asserted-by":"publisher","unstructured":"141. Ho RTH, Fong TCT, Wan AHY, Au-Yeung FSW, Wong CPK, Ng WYH, et al. A randomized controlled trial on the psychophysiological effects of physical exercise and Tai-chi in patients with chronic schizophrenia. Schizophr Res. 2016;171(1-3):42-9. doi: 10.1016\/j.schres.2016.01.038","DOI":"10.1016\/j.schres.2016.01.038"},{"key":"ref144","doi-asserted-by":"publisher","unstructured":"142. Malchow B, Keeser D, Keller K, Hasan A, Rauchmann BS, Kimura H, et al. Effects of endurance training on brain structures in chronic schizophrenia patients and healthy controls. Schizophr Res. 2016;173(3):182-91. doi: 10.1016\/j.schres.2015.01.005","DOI":"10.1016\/j.schres.2015.01.005"},{"issue":"2","key":"ref145","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s40473-016-0077-2","article-title":"Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits","volume":"3","author":"Vakhrusheva","year":"2016","unstructured":"143. Vakhrusheva J, Marino B, Stroup TS, Kimhy D. Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits. Curr Behav Neurosci Rep. 2016;3(2):165-175","journal-title":"Curr Behav Neurosci Rep"},{"issue":"2","key":"ref146","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/archgenpsychiatry.2009.193","article-title":"Hippocampal plasticity in response to exercise in schizophrenia","volume":"67","author":"Pajonk","year":"2010","unstructured":"144. Pajonk FG, Wobrock T, Gruber O, Scherk H, Berner D, Kaizl I, et al. Hippocampal plasticity in response to exercise in schizophrenia. Arch Gen Psychiatry. 2010;67(2):133-43.","journal-title":"Arch Gen Psychiatry"},{"key":"ref147","doi-asserted-by":"publisher","unstructured":"145. Svatkova A, Mandl RCW, Scheewe TW, Cahn W, Kahn RS, Hulshoff Pol HE. Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients with Schizophrenia and Healthy Controls. 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