{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:54:58Z","timestamp":1791294898918,"version":"4.1.0"},"reference-count":23,"publisher":"Archives of Endocrinology and Metabolism","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.20945\/2359-3997000000057","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T18:30:07Z","timestamp":1562005807000},"page":"480-484","source":"Crossref","is-referenced-by-count":6,"title":["The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus"],"prefix":"10.20945","volume":"62","author":[{"given":"Karla Simone Costa de","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Abbott Galv\u00e3o","family":"Ururahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonara Monique da Costa","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina Bezerra","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heglayne Pereira Vital da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Hernandes","family":"Bortolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Ducati","family":"Luchessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Fernando","family":"Arrais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros\u00e1rio Dominguez Crespo","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria das Gra\u00e7as","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio Hiroyuki","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Augusto de","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8510","published-online":{"date-parts":[[2018,8]]},"reference":[{"issue":"1","key":"key20190701143003_B1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/gene.2015.45","article-title":"The association between the HLA-G 14-bp insertion\/deletion polymorphism and type 1 diabetes. Genes Immun","volume":"17","author":"Silva","year":"2016","unstructured":"1. Silva HP V, Ururahy MAG, Souza KSC, Loureiro MB, Oliveira YMC, Oliveira GHM, et al. The association between the HLA-G 14-bp insertion\/deletion polymorphism and type 1 diabetes. Genes Immun. Genes Immun. 2016;17(1):13-8.","journal-title":"Genes Immun"},{"issue":"1","key":"key20190701143003_B2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.00003.2010","article-title":"Type 1 diabetes: etiology, immunology, and therapeutic strategies","volume":"91","author":"van Belle","year":"2011","unstructured":"2. van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev. 2011;91(1):79-118.","journal-title":"Physiol Rev"},{"issue":"Suppl. 1","key":"key20190701143003_B3","first-page":"S1","volume":"40","author":"American Diabetes Association","year":"2017","unstructured":"3. American Diabetes Association. Standards of Medical Care in Diabetes \u2013 2017 Diabetes Care. 2017;40(Suppl. 1):S1-35.","journal-title":"Standards of Medical Care in Diabetes \u2013 2017 Diabetes Care"},{"key":"key20190701143003_B4","first-page":"114","volume-title":"World J Diabetes","author":"Zemunik","year":"2013","unstructured":"4. Zemunik T, Boraska V. Genetics of Type 1 Diabetes. World J Diabetes. Split, Croatia: InTech; 2013;4(4):114-23."},{"issue":"7","key":"key20190701143003_B5","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.4049\/jimmunol.1502056","article-title":"Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility","volume":"196","author":"Ram","year":"2016","unstructured":"5. Ram R, Mehta M, Nguyen QT, Larma I, Boehm BO, Pociot F, et al. Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility. J Immunol. 2016 Apr 1;196(7):3043-53.","journal-title":"J Immunol"},{"issue":"1","key":"key20190701143003_B6","doi-asserted-by":"crossref","first-page":"a007732","DOI":"10.1101\/cshperspect.a007732","article-title":"Genetics of type 1 diabetes","volume":"2","author":"Noble","year":"2012","unstructured":"6. Noble JA, Erlich HA. Genetics of type 1 diabetes. Cold Spring Harb Perspect Med. 2012;2(1):a007732.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"key20190701143003_B7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00439-003-0940-6","article-title":"Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes","volume":"113","author":"Twells","year":"2003","unstructured":"7. Twells RC, Mein CA, Payne F, Veijola R, Gilbey M, Bright M, et al. Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes. Hum Genet. 2003;113(2):99-105.","journal-title":"Hum Genet"},{"issue":"5","key":"key20190701143003_B8","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1101\/gr.563703","article-title":"Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene","volume":"13","author":"Twells","year":"2003","unstructured":"8. Twells RCJ, Mein CA, Phillips MS, Hess JF, Veijola R, Gilbey M, et al. Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. Genome Res. 2003;13(5):845-55.","journal-title":"Genome Res"},{"issue":"2","key":"key20190701143003_B9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1086\/301974","article-title":"Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13","volume":"63","author":"Nakagawa","year":"1998","unstructured":"9. Nakagawa Y, Kawaguchi Y, Twells RC, Muxworthy C, Hunter KM, Wilson A, et al. Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. Am J Hum Genet. 1998;63(2): 547-56.","journal-title":"Am J Hum Genet"},{"issue":"1","key":"key20190701143003_B10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.0133792100","article-title":"Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion","volume":"100","author":"Fujino","year":"2003","unstructured":"10. Fujino T, Asaba H, Kang M, Ikeda Y, Sone H, Takada S, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A. 2003;100(1):229-34.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"key20190701143003_B11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.2009.03680.x","article-title":"Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia","volume":"72","author":"Saarinen","year":"2010","unstructured":"11. Saarinen A, Saukkonen T, Kivel\u00e4 T, Lahtinen U, Laine C, Somer M, et al. Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clin Endocrinol (Oxf). 2010;72(4):481-8.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"key20190701143003_B12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MOL.0000000000000445","article-title":"Wnt signaling in cardiovascular disease","volume":"28","author":"Gay","year":"2017","unstructured":"12. Gay A, Towler DA. Wnt signaling in cardiovascular disease. Curr Opin Lipidol. 2017;28(5):387-96.","journal-title":"Curr Opin Lipidol"},{"issue":"4","key":"key20190701143003_B13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1157\/13078029","article-title":"An\u00e1lisis estad\u00edstico de polimorfismos gen\u00e9ticos en estudios epidemiol\u00f3gicos","volume":"19","author":"Iniesta","year":"2005","unstructured":"13. Iniesta R, Guin\u00f3 E, Moreno V. An\u00e1lisis estad\u00edstico de polimorfismos gen\u00e9ticos en estudios epidemiol\u00f3gicos. Gac Sanit. 2005;19(4):333-41.","journal-title":"Gac Sanit"},{"issue":"6","key":"key20190701143003_B14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/ije\/dyi169","article-title":"The choice of a genetic model in the meta-analysis of molecular association studies","volume":"34","author":"Minelli","year":"2005","unstructured":"14. Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J. The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol. 2005;34(6):1319-28.","journal-title":"Int J Epidemiol"},{"issue":"7","key":"key20190701143003_B15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jclinepi.2007.12.011","article-title":"Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches","volume":"61","author":"Zintzaras","year":"2008","unstructured":"15. Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 2008;61(7):634-45.","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"key20190701143003_B16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/bioinformatics\/btm025","article-title":"SNPassoc: an R package to perform whole genome association studies","volume":"23","author":"Gonz\u00e1lez","year":"2007","unstructured":"16. Gonz\u00e1lez JR, Armengol L, Sol\u00e9 X, Guin\u00f3 E, Mercader JM, Estivill X, et al. SNPassoc: an R package to perform whole genome association studies. Bioinformatics. 2007;23(5):644-5.","journal-title":"Bioinformatics"},{"issue":"6","key":"key20190701143003_B17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ajhb.22464","article-title":"Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women","volume":"25","author":"Canto-Cetina","year":"2013","unstructured":"17. Canto-Cetina T, Polanco Reyes L, Gonz\u00e1lez Herrera L, Rojano-Me-j\u00eda D, Coral-V\u00e1zquez RM, Coronel A, et al. Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women. Am J Hum Biol. 2013;25(6):713-8.","journal-title":"Am J Hum Biol"},{"issue":"1","key":"key20190701143003_B18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12952-016-0059-7","article-title":"Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women","volume":"15","author":"Kitjaroentham","year":"2016","unstructured":"18. Kitjaroentham A, Hananantachai H, Phonrat B, Preutthipan S, Tungtrongchitr R. Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women. J Negat Results Biomed. 2016;15(1):16.","journal-title":"J Negat Results Biomed"},{"issue":"4","key":"key20190701143003_B19","article-title":"Functional relevance for associations between osteoporosis and genetic variants","volume":"12","author":"Liu","year":"2017","unstructured":"19. Liu K,Tan L-J, Wang P, Chen X-D, Zhu L-H, Zeng Q, et al. Functional relevance for associations between osteoporosis and genetic variants. PLoS One. 2017;12(4):e0174808.","journal-title":"PLoS One"},{"key":"key20190701143003_B20","doi-asserted-by":"crossref","first-page":"290531","DOI":"10.1155\/2014\/290531","article-title":"Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis","volume":"2014","author":"Xu","year":"2014","unstructured":"20. Xu G-Y, Qiu Y, Mao H-J. Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis. Biomed Res Int. 2014;2014:290531.","journal-title":"Biomed Res Int"},{"issue":"1","key":"key20190701143003_B21","first-page":"247","article-title":"Association of LRP5 gene polymorphism with type 2 diabetes mellitus and osteoporosis in postmenopausal women","volume":"7","author":"Xuan","year":"2014","unstructured":"21. Xuan M, Wang Y, Wang W, Yang J, Li Y, Zhang X. Association of LRP5 gene polymorphism with type 2 diabetes mellitus and osteoporosis in postmenopausal women. Int J Clin Exp Med. 2014;7(1):247-54.","journal-title":"Int J Clin Exp Med"},{"issue":"10","key":"key20190701143003_B22","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1177\/002215540004801006","article-title":"Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes","volume":"48","author":"Figueroa","year":"2000","unstructured":"22. Figueroa DJ, Hess JF, Ky B, Brown SD, Sandig V, Hermanowski-Vosatka A, et al. Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. J Histochem Cytochem. 2000;48(10):1357-68.","journal-title":"J Histochem Cytochem"},{"key":"key20190701143003_B23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.ctdb.2015.11.028","article-title":"Frizzled Receptors in Development and Disease","volume":"117","author":"Wang","year":"2016","unstructured":"23. Wang Y, Chang H, Rattner A, Nathans J. Frizzled Receptors in Development and Disease. Curr Top Dev Biol. 2016;117:113-39.","journal-title":"Curr Top Dev Biol"}],"container-title":["Archives of Endocrinology and Metabolism"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T23:25:18Z","timestamp":1610148318000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S2359-39972018000400480&lng=en&nrm=iso"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["10.20945\/2359-3997000000057"],"URL":"https:\/\/doi.org\/10.20945\/2359-3997000000057","relation":{},"ISSN":["2359-3997","2359-4292"],"issn-type":[{"value":"2359-3997","type":"print"},{"value":"2359-4292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}