{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:47:13Z","timestamp":1786132033374,"version":"build-2736575974"},"reference-count":0,"publisher":"Archives of Endocrinology and Metabolism","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["A&amp;EM"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Objective: To evaluate bone density and microstructure, fragility fractures, and hormones in men 50 years and older receiving\nantiseizure medications (ASMs). Subjects and methods: Study population included 39 men with difficult-to-control epilepsy and\n42 healthy men as control group. Spine and hip areal bone mineral density (aBMD), body composition and vertebral fracture\nassessment (VFA) were evaluated using Dual-Energy X-Ray Absorptiometry (DXA). Volumetric bone mineral density (vBMD)\nand microarchitecture of trabecular and cortical compartments were evaluated using High-Resolution Peripheral Quantitative\nComputed Tomography (HR-pQCT). Physical activity was tested by the International Physical Activity Questionnaire (IPAQ).\nThe fracture risk was estimated by fracture risk assessment tool (FRAX). Results: ASMs patients showed lower cortical bone\nthickness (Ct.Th) in distal tibia (1.196 \u00b1 0.295 vs. 1.341 \u00b1 0.241 mm, p = 0.03), more fractures (12 vs. 2, p = 0.003) mostly morphometric\nvertebral fractures, and a higher risk for major and hip fractures based on FRAX. Hormonal changes included higher\nmedian parathyroid hormone (PTH) (50.4 vs. 24 pg\/mL, p &lt; 0.001) possibly associated with vitamin D insufficiency, (25(OH)D\nlevels below 30 ng\/mL in 43.6% of ASMs patients), lower median Estradiol that was an independent factor for fractures (p =\n0.04) and bioavailable Testosterone in the lowest quartile in 52 % of them. Conclusion: Men on ASMs exhibit lower Ct.Th and\nhormone changes that may contribute to bone fragility. While clinical fractures are infrequent, it is crucial to actively search for\nmorphometric fractures, either during DXA or through the more available method of spine X-rays.<\/jats:p>","DOI":"10.20945\/2359-4292-2026-0082","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:08:11Z","timestamp":1786129691000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive insights into bone health, hormonal patterns, and fracture risks among men with drug resistant epilepsy: a crucial evaluation"],"prefix":"10.20945","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1476-4047","authenticated-orcid":false,"given":"Cristian","family":"Pieper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-3985","authenticated-orcid":false,"given":"Leonardo","family":"Vieira Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-1407","authenticated-orcid":false,"given":"Eduardo","family":"Ferreira da Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-0993","authenticated-orcid":false,"given":"Francisco","family":"P. Paranhos Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-2880","authenticated-orcid":false,"given":"Miguel","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2129-3546","authenticated-orcid":false,"given":"Laura","family":"M. Carvalho Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-6849","authenticated-orcid":false,"given":"Isabella","family":"D\u2019Andrea Meira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-3250","authenticated-orcid":false,"given":"Maria","family":"Lucia Fleiuss Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8510","published-online":{"date-parts":[[2026]]},"container-title":["Archives of Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.aem-sbem.com\/article\/comprehensive-insights-into-bone-health-hormonal-patterns-and-fracture-risks-among-men-with-drug-resistant-epilepsy-a-crucial-evaluation\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:08:11Z","timestamp":1786129691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aem-sbem.com\/article\/comprehensive-insights-into-bone-health-hormonal-patterns-and-fracture-risks-among-men-with-drug-resistant-epilepsy-a-crucial-evaluation\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.20945\/2359-4292-2026-0082","relation":{},"ISSN":["2359-3997"],"issn-type":[{"value":"2359-3997","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}