{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:48:50Z","timestamp":1782373730101,"version":"3.54.5"},"reference-count":34,"publisher":"ARAN Ediciones","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr Hosp"],"published-print":{"date-parts":[[2026]]},"DOI":"10.20960\/nh.06674","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:17:53Z","timestamp":1782371873000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations between vitamin D levels, nutritional status, and inflammation in sepsis \u2012 A cross-sectional study"],"prefix":"10.20960","author":[{"given":"Ying","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyong","family":"Bei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Rui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Cheng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Xue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8588","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2023.154400"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.754348"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-024-00139-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-024-01665-2"},{"key":"ref6","unstructured":"Dua J, Jadhav RS, Bahal M, Mane S, Kale S, Garlapati S, et al. Association Between Vitamin D Deficiency and Sepsis in Term Neonates: A Case-Control Study. Cureus 2024;16(10):e72468."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Collins K, Huen SC. Metabolism and Nutrition in Sepsis: In Need of a Paradigm Shift. Nephron 2023;147(12):733-6.","DOI":"10.1159\/000534074"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Cha JK, Kim HS, Kim EJ, Lee ES, Lee JH, Song IA. Effect of Early Nutritional Support on Clinical Outcomes of Critically Ill Patients with Sepsis and Septic Shock: A Single-Center Retrospective Study. Nutrients 2022;14(11):2318.","DOI":"10.3390\/nu14112318"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"De Waele E, Malbrain MLNG, Spapen H. Nutrition in Sepsis: A Bench-to-Bedside Review. Nutrients 2020;12(2):395.","DOI":"10.3390\/nu12020395"},{"key":"ref10","unstructured":"Hamilton FW, Thomas M, Arnold D, Palmer T, Moran E, Mentzer AJ, et al. Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study. PLoS Med 2023;20(1):e1004174."},{"key":"ref11","unstructured":"An X, Zhang X, ShangGuan Y. Application of PCT, IL-6, CRP, and WBC for Diagnosing Neonatal Sepsis. Clin Lab 2023;69(8):10.7754."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 2021;47(11):1181-247.","DOI":"10.1007\/s00134-021-06506-y"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Huang C, Zhang C, Zhang J. Vitamin D and Molecules Related to Vitamin D Metabolism in Children with Sepsis. J Inflamm Res 2024;17:10547-56.","DOI":"10.2147\/JIR.S489233"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Guan J, Shichen M, Liang Z, Yu S, Zhao M, Zhang L, et al. Potential benefits of vitamin D for sepsis prophylaxis in critical ill patients. Front Nutr 2023;10:1073894.","DOI":"10.3389\/fnut.2023.1073894"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Sun Y, Pu Z, Zhao H, Deng Y, Zhang J, Li S, et al. Vitamin D can mitigate sepsis-associated neurodegeneration by inhibiting exogenous histone-induced pyroptosis and ferroptosis: Implications for brain protection and cognitive preservation. Brain Behav Immun 2025;124:40-54.","DOI":"10.1016\/j.bbi.2024.11.019"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96(7):1911-30.","DOI":"10.1210\/jc.2011-0385"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Grant WB, Wimalawansa SJ, Pludowski P, Cheng RZ. Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines. Nutrients 2025;17(2):277.","DOI":"10.3390\/nu17020277"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Loni R, Zameer S, Hasan FA, Abbas I, Mesrati H, George J, et al. Vitamin-D Status and Clinical Outcomes in Critically Ill Children. Indian J Crit Care Med 2023;27(7):503-9.","DOI":"10.5005\/jp-journals-10071-24486"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Chen L, Zhou T, Lv C, Ni H, Zhao Z, Zhou H, Hu X. Vitamin D supplementation can improve the 28-day mortality rate in patients with sepsis associated acute kidney injury. Ren Fail 2024;46(2):2431632.","DOI":"10.1080\/0886022X.2024.2431632"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Braun AB, Gibbons FK, Litonjua AA, Giovannucci E, Christopher KB. Low Serum 25-Hydroxyvitamin D at Critical Care Initiation Is Associated with Increased Mortality. Crit Care Med 2012;40(1):63-72.","DOI":"10.1097\/CCM.0b013e318260c928"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Diaz-Fuentes G. Vitamin D Deficiency Is Associated with Mortality in the Medical Intensive Care Unit. Crit Care 2011;15(6):R292.","DOI":"10.1186\/cc10585"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Hou F, Gao J, Zhang L, Liu C. Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis. Cytokine 2024;179:156597.","DOI":"10.1016\/j.cyto.2024.156597"},{"key":"ref23","unstructured":"Kubo K, Sakuraya M, Sugimoto H, Takahashi N, Kano KI, Yoshimura J, et al. Benefits and Harms of Procalcitonin- or C-Reactive Protein-Guided Antimicrobial Discontinuation in Critically Ill Adults with Sepsis: A Systematic Review and Network Meta-Analysis. Crit Care Med 2024;52(10):e522-e34."},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Patel JJ, L\u00f3pez-Delgado JC, Stoppe C, McClave SA. Enteral nutrition in septic shock: a call for a paradigm shift. Curr Opin Crit Care 2024;30(2):165-71.","DOI":"10.1097\/MCC.0000000000001134"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"De Waele E, Malbrain MLNG, Spapen H. Nutrition in Sepsis: A Bench-to-Bedside Review. Nutrients 2020;12(2):395.","DOI":"10.3390\/nu12020395"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Barber G, Tanic J, Leligdowicz A. Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review. Curr Opin Lipidol 2023;34(2):70-81.","DOI":"10.1097\/MOL.0000000000000870"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Hager DN, Hooper MH, Bernard GR, Busse LW, Ely EW, Fowler AA, et al. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. Trials 2019;20(1):197.","DOI":"10.1186\/s13063-019-3254-2"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Moon SJ, Ko RE, Park CM, Suh GY, Hwang J, Chung CR. The Effectiveness of Early Enteral Nutrition on Clinical Outcomes in Critically Ill Sepsis Patients: A Systematic Review. Nutrients 2023;15(14):3201.","DOI":"10.3390\/nu15143201"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Grillo-Ardila CF, Tibavizco-Palacios D, Triana LC, Rugeles SJ, Vallejo-Ortega MT, Calder\u00f3n-Franco CH, et al. Early Enteral Nutrition (within 48 h) for Patients with Sepsis or Septic Shock: A Systematic Review and Meta-Analysis. Nutrients 2024;16(11):1560.","DOI":"10.3390\/nu16111560"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, et al.; A.S.P.E.N. Board of Directors; American College of Critical Care Medicine; Society of Critical Care Medicine. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr 2009 May-Jun;33(3):277-316.","DOI":"10.1177\/0148607109335234"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med 2017;43(3):304-77.","DOI":"10.1007\/s00134-017-4683-6"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, et al. ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit. Clin Nutr 2023;42(9):1671-89.","DOI":"10.1016\/j.clnu.2023.07.011"},{"key":"ref33","unstructured":"Wang N, Qin Z, Liu H, Shang N, Wang Y, Xi X. Clinical value of nutritional risk scores in patients with sepsis associated acute renal injury. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022;34(3):245-9."},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Gao Q, Cheng Y, Li Z, Tang Q, Qiu R, Cai S, et al. Association Between Nutritional Risk Screening Score and Prognosis of Patients with Sepsis. Infect Drug Resist 2021;14:3817-25.","DOI":"10.2147\/IDR.S321385"}],"container-title":["Nutrici\u00f3n Hospitalaria"],"original-title":[],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:22:27Z","timestamp":1782372147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nutricionhospitalaria.org\/articles\/06674\/show"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":34,"URL":"https:\/\/doi.org\/10.20960\/nh.06674","relation":{},"ISSN":["1699-5198","0212-1611"],"issn-type":[{"value":"1699-5198","type":"electronic"},{"value":"0212-1611","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}