{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:49:34Z","timestamp":1782143374631,"version":"3.54.5"},"reference-count":33,"publisher":"ARAN Ediciones","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr Hosp"],"published-print":{"date-parts":[[2026]]},"DOI":"10.20960\/nh.06955","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:20:09Z","timestamp":1782141609000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical evidence on kefir consumption and human health"],"prefix":"10.20960","author":[{"given":"Mar","family":"Larrosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Clemene Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mart\u00ednez L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz G.","family":"G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8588","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422416000275"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/foods13071026"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac054"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1587831"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422423000070"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare14050652"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Yahyapoor F, Haghighat N, Sohrabi Z, Asbaghi O, Bagherniya M, Jamialahmadi T, et al. Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Curr Drug Targets 2023;24(7):599-612.","DOI":"10.2174\/1389450124666230427095742"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Hamsho M, Hawari R, Ye\u015fil Z, Dakhel Z, Dursun Saydam D, Terzi M, et al. Effect of different kefir dosages on inflammation status, metabolic profile, and anthropometric measurements in adults: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis 2025;104364.","DOI":"10.1016\/j.numecd.2025.104364"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Rashidbeygi E, Samarin MM, Sheikhhossein F, Khalilkhaneh AH, Gholizadeh M, Lohrasbi N, et al. The effect of kefir consumption on blood pressure and C-Reactive Protein: A systematic review and meta-analysis of randomised controlled trials. Endocrinol Diabetes Metab 2025;8(6):e70124.","DOI":"10.1002\/edm2.70124"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Ghizi AC da S, de Almeida Silva M, Moraes FS de A, da Silva CL, Endringer DC, Scherer R, et al. Kefir improves blood parameters and reduces cardiovascular risks in patients with metabolic syndrome. Pharma Nutrition 2021;16:100266.","DOI":"10.1016\/j.phanu.2021.100266"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yilmaz B, Sharma H, Melekoglu E, Ozogul F. Recent developments in dairy kefir-derived lactic acid bacteria and their health benefits. Food Bioscience 2022;46:101592.","DOI":"10.1016\/j.fbio.2022.101592"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Pra\u017enikar ZJ, Kenig S, Vardjan T, Bizjak M\u010c, Petelin A. Effects of kefir or milk supplementation on zonulin in overweight subjects. J Dairy Sci 2020;103(5):3961-70.","DOI":"10.3168\/jds.2019-17696"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Vieira CP, Rosario AILS, Lelis CA, Rekowsky BSS, Carvalho APA, Ros\u00e1rio DKA, et al. Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis. Oxid Med Cell Longev 2021;2021:9081738.","DOI":"10.1155\/2021\/9081738"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Qaisrani ZN, Lin WP, Lay BB, Phyo KY, San MM, Awaeloh N, et al. The Impact of Kefir Consumption on Inflammation, Oxidative Stress Status, and Metabolic-Syndrome-Related Parameters in Animal Models: A Systematic Review and Meta-Analysis. Foods 2025;14(12):2077.","DOI":"10.3390\/foods14122077"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Neves MAS, de Paulo RS, Bressan J, Pereira SS, Kravchychyn ACP, Hermsdorff HHM. Kefir and Its By-Products Supplementation Reduces Inflammation and Oxidative Stress, Improves Intestinal Barrier Integrity, and Modulates the Gut Microbiota in Animal Models of Inflammatory Bowel Disease: A Systematic Review. Probiotics & Antimicro Prot 2026.","DOI":"10.1007\/s12602-026-10948-5"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Sharifi M, Moridnia A, Mortazavi D, Salehi M, Bagheri M, Sheikhi A. Kefir: a powerful probiotics with anticancer properties. Med Oncol 2017;34(11):183.","DOI":"10.1007\/s12032-017-1044-9"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Brasiel PG de A, Dutra Medeiros J, Costa de Almeida T, Teodoro de Souza C, de C\u00e1ssia \u00c1vila Alpino G, Barbosa Ferreira Machado A, et al. Preventive effects of kefir on colon tumor development in Wistar rats: gut microbiota critical role. J Dev Orig Health Dis 2025;16:e5.","DOI":"10.1017\/S2040174424000461"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Medrano M, Cordova C, Rodriguez B, Simonelli N, Olivero P, Abraham AG. KEFIRAN in vitro biological activity on enterocytes and mesodermal origin cell lines: Focus on adenocarcinoma cells HT29. Bioactive Carbohydrates and Dietary Fibre 2024; 32:100457.","DOI":"10.1016\/j.bcdf.2024.100457"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Choi Y, Keum GB, Kang J, Doo H, Kwak J, Kim H, et al. Evaluation of kefir consumption on gut microbial diversity in a healthy young population using full-length 16S rRNA sequencing. Front Microbiol 2025;16:1587831.","DOI":"10.3389\/fmicb.2025.1587831"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Alali MA, Shori AB. Recent advances in the modulatory effects of kefir on the gut microbiota. Explor Foods Foodomics 2025;3:1010107.","DOI":"10.37349\/eff.2025.1010107"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Kordkatouli M, Koohsari H, Maroufi M, Sadegh Shesh Poli M, Zamani F. (PDF) Impact of Kefir on Gut Microbiota, Immune System Activation, and Metabolic Health: A Comprehensive Analysis of its Health Benefits. Hormozgan Med J 2025;29(2):99-108.","DOI":"10.34172\/hmj.8408"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Bak\u0131rhan H, Ozyurek Arpa F, Pehlivan M, Kalkan I. Effects of Kefir Consumption on Gastrointestinal Health, Biochemical Parameters, Sleep, and Mental Well-Being in Healthy Young Adults: a Randomized Controlled Trial. J Nutr 2026;156(1):101247.","DOI":"10.1016\/j.tjnut.2025.11.016"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Tanure YCB, Mafra ACM, Guimar\u00e3es BLM, Magalh\u00e3es RC, Fagundez C, Nascimento IJB do, et al. Potential benefits of kefir and its compounds on Alzheimer\u2019s disease: A systematic review. Brain Behav Immun Integr 2025;10:100115.","DOI":"10.1016\/j.bbii.2025.100115"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"El Sayed NS, Kandil EA, Ghoneum MH. Enhancement of Insulin\/PI3K\/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer\u2019s Disease Model in Mice. Front Pharmacol 2021;12.","DOI":"10.3389\/fphar.2021.666502"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Liu S, Gao J, Zhu M, Liu K, Zhang HL. Gut Microbiota and Dysbiosis in Alzheimer\u2019s Disease: Implications for Pathogenesis and Treatment. Mol Neurobiol 2020;57(12):5026-43.","DOI":"10.1007\/s12035-020-02073-3"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Peluzio M do CG, Dias M de ME, Martinez JA, Milagro FI. Kefir and Intestinal Microbiota Modulation: Implications in Human Health. Front Nutr 2021;8:638740.","DOI":"10.3389\/fnut.2021.638740"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Ton AMM, Campagnaro BP, Alves GA, Aires R, C\u00f4co LZ, Arpini CM, et al. Oxidative Stress and Dementia in Alzheimer\u2019s Patients: Effects of Synbiotic Supplementation. Oxid Med Cell Longev 2020;2020:2638703.","DOI":"10.1155\/2020\/2638703"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Cannavale CN, Mysonhimer AR, Bailey MA, Cohen NJ, Holscher HD, Khan NA. Consumption of a fermented dairy beverage improves hippocampal-dependent relational memory in a randomized, controlled cross-over trial. Nutr Neurosci 2023;26(3):265-74.","DOI":"10.1080\/1028415X.2022.2046963"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Lawrence K, Fibert P, Toribio-Mateas M, Gregory AM, Hobbs J, Quadt F, et al. Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial. BMC Psychiatry 2025;25(1):1117.","DOI":"10.1186\/s12888-025-07568-8"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"\u00d6ne\u015f E, Zavot\u00e7u M, Nisan N, Ba\u015f M, Sa\u011flam D. Effects of Kefir Consumption on Gut Microbiota and Athletic Performance in Professional Female Soccer Players: A Randomized Controlled Trial. Nutrients 2025;17(3):512.","DOI":"10.3390\/nu17030512"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Jung SH, Hwang S, Seo KH, Park Y, Kim MJ, Kim H. Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2025;17(24):3937.","DOI":"10.3390\/nu17243937"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Athira M, Singh BP, Sarkar P, Hassan AK, Abidi KH, Kovaleva EG, et al. A comprehensive review on kefir: composition, microbial diversities, meta-analysis and biological significances on human health. Food Prod Process and Nutr 2026;8(1):6.","DOI":"10.1186\/s43014-025-00351-y"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Gupta VK, Rajendraprasad S, Ozkan M, Ramachandran D, Ahmad S, Bakken JS, et al. Safety, feasibility, and impact on the gut microbiome of kefir administration in critically ill adults. BMC Med 2024;22(1):80.","DOI":"10.1186\/s12916-024-03299-x"}],"container-title":["Nutrici\u00f3n Hospitalaria"],"original-title":[],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:20:39Z","timestamp":1782141639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nutricionhospitalaria.org\/articles\/06955\/show"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"URL":"https:\/\/doi.org\/10.20960\/nh.06955","relation":{},"ISSN":["1699-5198","0212-1611"],"issn-type":[{"value":"1699-5198","type":"electronic"},{"value":"0212-1611","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}