{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:27:47Z","timestamp":1790706467922,"version":"4.1.0"},"reference-count":0,"publisher":"ARAN Ediciones","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr Hosp"],"abstract":"<jats:p>Introduction: Intestinal ischemia-reperfusion (I\/R) injury may cause cell and tissue damage, reaching also other organs such as the liver. Because of the involvement of free radicals in I\/R injury, treatment options with antioxidants have been studied and tested.Objective: To evaluate the effect of glutamine (Gln) in the liver of animals with intestinal I\/R injury.Methods: We used 20 male Wistar rats divided into four groups: sham-operated (SO); glutamine + sham-operated (G+SO); intestinal ischemia-reperfusion (I\/R); glutamine + intestinal ischemia-reperfusion (G+I\/R). The superior mesenteric artery was clamped for 30 minutes and reperfused for 15 minutes. Gln (25 mg\/kg\/day) diluted in 1 ml of saline was administered intraperitoneally on the two days before I\/R induction.Results: Levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), lipid peroxidation (LPO) and expressions of interleukin-6 (IL-6) and nuclear factor kappa B (NF-kB) showed a significant reduction in the G+I\/R group as compared with the I\/R group. The activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the levels of glutathione (GSH) showed an increase in the G+I\/R group as compared with the I\/R group.Conclusion: Pretreatment with Gln reduced oxidative, tissue damage and showed a decrease expression of inflammatory mediators.<\/jats:p>","DOI":"10.20960\/nh.643","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T07:14:59Z","timestamp":1498115699000},"page":"548","source":"Crossref","is-referenced-by-count":18,"title":["Effect of glutamine on liver injuries induced by intestinal ischemia-reperfusion in rats"],"prefix":"10.20960","volume":"34","author":[{"given":"Renata","family":"Hartmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielli","family":"Licks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliz\u00e2ngela Gon\u00e7alves","family":"Schemitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josieli Raskopf","family":"Colares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmara Pandolfo","family":"Zabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Sarubbi","family":"Fillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Possa","family":"Marroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8588","published-online":{"date-parts":[[2017,6,5]]},"container-title":["Nutrici\u00f3n Hospitalaria"],"original-title":[],"link":[{"URL":"http:\/\/revista.nutricionhospitalaria.net\/index.php\/nh\/article\/viewFile\/643\/559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revista.nutricionhospitalaria.net\/index.php\/nh\/article\/viewFile\/643\/559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:28:31Z","timestamp":1498145311000},"score":1,"resource":{"primary":{"URL":"http:\/\/revista.nutricionhospitalaria.net\/index.php\/nh\/article\/view\/643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,6,5]]}},"URL":"https:\/\/doi.org\/10.20960\/nh.643","relation":{},"ISSN":["1699-5198","0212-1611"],"issn-type":[{"value":"1699-5198","type":"electronic"},{"value":"0212-1611","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}