{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:45:38Z","timestamp":1789821938786,"version":"4.0.1"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJID"],"published-print":{"date-parts":[[2021,1,21]]},"abstract":"<jats:p>Acalypha wilkesiana (AW), a popular medicinal plant has been used in traditional medicine to treat a variety of skin disorders including pityriasis versicolor and seborrheic dermatitis. As a prelude to clinical trials in humans, an experimental study was carried out to determine the spectrum of antifungal activity of 2 variants of the Acalypha wilkesiana plant.  Materials and Methods: The ethanol extract and herbal cream formulation of the dried leaves of 2 cultivars (Macrophylla &amp; Hoffmani) of Acalypha wilkesiana were investigated for in-vitro antifungal activity by disc diffusion and micro-broth dilution techniques. Organisms tested were typed cultures of Malassezia furfur, Candida albicans and Trichophyton rubrum; and clinical strains of Microsporum canis and Epidermophyton floccosum.  Results: Both cultivars (Macrophylla and Hoffmanii) of the plant showed good activity against all the fungi tested except Microsporum canis (8.0\u00b10.00; 7.00\u00b10.00 mm). The greatest activity was observed against Trichophyton rubrum (22.0\u00b10.00; 24.00\u00b10.00 mm) while Candida albicans showed the least activity (15.0\u00b10.00; 18.00\u00b10.57 mm). The Minimum Inhibitory Concentration (MIC) of the crude extract ranged between 0.25 and 8 mg\/ml for all organisms, while that of the herbal cream was 0.31-8mg\/ml.  The lowest MIC was seen with Candida albicans for both varieties of the plant. The Acalypha wilkesiana Hoffmanii demonstrated a greater activity against Candida albicans and Malassezia furufur than the A. wilkesiana (Macrophylla).  Conclusion: This study reveals Acalypha wilkesiana leaf extract has potential for development as a cream that can be used to treat superficial fungal skin infections.<\/jats:p>","DOI":"10.21010\/ajid.v16i1.4","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T03:56:55Z","timestamp":1641787015000},"page":"21-30","source":"Crossref","is-referenced-by-count":11,"title":["ANTI-FUNGAL ACTIVITY OF ACALYPHA WILKESIANA: A PRELIMINARY STUDY OF FUNGAL ISOLATES OF CLINICAL SIGNIFICANCE"],"prefix":"10.21010","volume":"16","author":[{"given":"Katibi Oludolapo","family":"Sherifat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboh Mercy","family":"Itohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salawu Oluwakayinsola","family":"Adeola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kola -Mustapha","family":"Adeola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatunji Lawrence","family":"Aderemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8656","published-online":{"date-parts":[[2021,12,21]]},"container-title":["African Journal of Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/journals.athmsi.org\/index.php\/AJID\/article\/view\/6030\/3281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T06:25:47Z","timestamp":1641795947000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.athmsi.org\/index.php\/AJID\/article\/view\/6030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12,21]]},"published-print":{"date-parts":[[2022,1,21]]}},"URL":"https:\/\/doi.org\/10.21010\/ajid.v16i1.4","relation":{},"ISSN":["2006-0165","2505-0419"],"issn-type":[{"value":"2006-0165","type":"print"},{"value":"2505-0419","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}