{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T16:31:59Z","timestamp":1720456319123},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Ovarian cancer is associated with poor survival, because patients are diagnosed at an advanced stage of the disease, and&#x0D;\nin addition, tumors develop chemoresistance, which carries a poor prognosis for the patient.&#x0D;\nMaterial and methods: We hypothesize that high expression of SDF-1, survivin and smac is associated with ovarian cancers&#x0D;\ndevelopment and could be used as a biomarker to identify this disease. The expressions of SDF-1, survivin and smac in normal&#x0D;\novarian (NO) tissue, benign tumor (BT) tissue and epithelial ovarian cancer (EOC) tissue were immunohistochemically analysed.&#x0D;\nResults: Positive expressions of SDF-1, survivin and smac were significantly higher in EOC tissue than those in NO and BT tissues.&#x0D;\nSDF-1 expressions were significantly more weaker in advanced ovarian carcinomas (FIGO stage III\u2013IV), and in high-grade&#x0D;\ncarcinomas. There was a positive correlation between EOC patients with lymph node metastasis and with ascites and SDF-1&#x0D;\npositivity (P &lt; 0.05). Survivin expressions were significantly more stronger in advanced ovarian carcinomas (FIGO stage III\u2013IV), and in high-grade carcinomas. There was a positive correlation between EOC patients with lymph node metastasis and with ascites and surviving positivity (P &lt; 0.05). Smac expressions were significantly more stronger in advanced ovarian carcinomas (FIGO stage III\u2013IV), and in high-grade carcinomas. There was a positive correlation between EOC patients with lymph node metastasis and with ascites and smac positivity (P &lt; 0.05).<\/jats:p>","DOI":"10.21010\/ajtcam.v13i4.12","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T11:32:31Z","timestamp":1461324751000},"page":"81-87","source":"Crossref","is-referenced-by-count":3,"title":["EVALUATION THE EXPRESSION OF THREE GENES TO EPITHELIAL OVARIAN CANCER RISK IN CHINESE POPULATION"],"prefix":"10.21010","volume":"13","author":[{"given":"Ju","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming En","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2016,7,3]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4070\/2459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4070\/2459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:13:39Z","timestamp":1683537219000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,3]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,3]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v13i4.12","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,3]]}}}