{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:03:10Z","timestamp":1791385390031,"version":"4.3.3"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese medicinal herbs. Salvianolic acid B (Sal B), a\r\nbioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and\r\nanti-oxidantive effects.\r\nMaterial and method: To study the cardioprotective effects of salvianolic acid B (Sal B) on acute myocardial ischemia reperfusion\r\n(MIR) injury rats, on the basis of this investigation, the possible mechanism of salvianolic acid B was elucidated. Male Sprague-\r\nDawley rats (200\u2013220 g) were randomly divided into five groups: sham-operated, MIR, MIR + Sal B (10 mg\/kg\/day, orally), MIR +\r\nSal B (20 mg\/kg\/day, orally) and MIR + Sal B (30 mg\/kg\/day, orally). Before operation, the foregoing groups were pretreated with\r\nhomologous drug once a day for 7 days, respectively. After twelve hours in MIR, the cardioprotective effects of SPJ were evaluated\r\nby infarct size, biochemical values, and the antioxidative and antiapoptotic relative gene expressions.\r\nResults: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-\u03b1 and\r\nIL-1\u03b2 levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the\r\nincreased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax.\r\nConclusion: In ischemic myocardium, oxidative stress caused the overgeneration and accumulation of reactive oxygen species\r\n(ROS), which was central of cardiac ischemic injury. Sal B exerted beneficially cardioprotective effects on myocardial ischemia\r\ninjury rats, mainly scavenging oxidative stress-triggered overgeneration and accumulation of ROS, alleviating myocardial ischemia\r\ninjury and cardiac cell death.<\/jats:p>","DOI":"10.21010\/ajtcam.v13i4.20","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T11:32:31Z","timestamp":1461324751000},"page":"157-161","source":"Crossref","is-referenced-by-count":35,"title":["MYOCARDIUM PROTECTIVE FUNCTION OF SALVIANOLIC ACID B IN ISCHEMIA REPERFUSION RATS"],"prefix":"10.21010","volume":"13","author":[{"given":"Zengyong","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8656","published-online":{"date-parts":[[2016,7,3]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4086\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:13:06Z","timestamp":1683537186000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,3]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,3]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v13i4.20","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,3]]}}}