{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:19:15Z","timestamp":1792491555800,"version":"4.5.0"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs\r\nemployed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to\r\nevaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico\r\nas an anti-infective in febrile-type diseases.\r\nMaterials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested\r\nagainst Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of\r\npristimerin and tingenone was performed.\r\nResults: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50\u2019s of 0.80,\r\n0.44, 0.46, and 2.68 \u03bcg\/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).\r\nConclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.<\/jats:p>","DOI":"10.21010\/ajtcam.v13i4.21","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T11:32:31Z","timestamp":1461324751000},"page":"162-165","source":"Crossref","is-referenced-by-count":11,"title":["ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)"],"prefix":"10.21010","volume":"13","author":[{"given":"Carolina","family":"Roca-M\u00c3\u00a9zquita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio","family":"Graniel-Sabido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa E.","family":"Moo-Puc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena V.","family":"Leon-D\u00c3\u00a9niz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00c3\u00ad","family":"Gamboa-Le\u00c3\u00b3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carely","family":"Arjona-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tun-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gumersindo","family":"Mir\u00c3\u00b3n-L\u00c3\u00b3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo J.","family":"Mena-Rejon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8656","published-online":{"date-parts":[[2016,7,3]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"https:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3615\/2470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3615\/2470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T09:04:58Z","timestamp":1686819898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/3615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,3]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,3]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v13i4.21","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,3]]}}}