{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:22:39Z","timestamp":1773908559795,"version":"3.50.1"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Vascular dementia (VD) is the most frequent psychiatric complication of stroke, and is often difficult to treat.\r\nIncidence rate of vascular cognition impairment is still 70% after stroke in one year (Sui R et al.2011). Stroke patients with VD\r\nsuffer from a higher mortality rate and have worse functional outcomes and quality of life. However, despite the extensive literatures\r\non this topic, there is no agreement on the causal mechanisms and effective therapy for VD. The objective of this study is to examine\r\nif electroacupuncture at the Wangu acupoint (GB 12), whose position is similar to the cerebellar fastigial nucleus, could reduce\r\ninflammatory cytokines in the hippocampus of rats with vascular dementia (VD).\r\nMaterials and Methods: The 54 healthy, male, Sprague-Dawley (SD) rats, 9 months old, and of clean grade (300-450) g, were\r\nrandomly divided into three groups: sham surgery group, VD group and electro-acupuncture group. The ethology scores of VD rats\r\nwere evaluated and the mRNA expressions of inflammatory cytokines (TNF-\u03b1, IL-6 and IL-1\u03b2) in the hippocampus were assessed\r\nand the hippocampal tissues were observed by hematoxylin-eosin staining.\r\nResults: Compared with the VD group, in the electroacupuncture group, the rats\u2019 learning ability improved significantly and the\r\nmRNA expression of TNF-\u03b1, IL-6 and IL-1\u03b2 decreased. Simultaneously, the damage extent of nerve cells in the hippocampal tissues\r\ndecreased, with their morphology recovered to nearly normal.\r\nConclusions: Electro-acupuncture at the Wangu acupoint can decrease the levels of inflammatory cytokines in the hippocampus,\r\nreduce the damage extent of nerve cells in the hippocampus, and thus provide a new neuroprotective method in VD<\/jats:p>","DOI":"10.21010\/ajtcam.v13i5.3","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T13:30:22Z","timestamp":1653744622000},"page":"17-24","source":"Crossref","is-referenced-by-count":14,"title":["ELECTROACUPUNCTURE AT THE WANGU ACUPOINT SUPPRESSES EXPRESSION OF INFLAMMATORY CYTOKINES IN THE HIPPOCAMPUS OF RATS WITH VASCULAR DEMENTIA"],"prefix":"10.21010","volume":"13","author":[{"given":"Yanan","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubo","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2016,8,12]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3892\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3892\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:09:19Z","timestamp":1683536959000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/3892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,8,12]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v13i5.3","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8,12]]}}}