{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:00:13Z","timestamp":1775908813279,"version":"3.50.1"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: The aim of this study was to investigate Cytotoxic, \u03b1-Chymotrypsin and Urease inhibition activities of the plant\r\nHeliotropium dasycarpum.\r\nMaterials &amp; Methods: Dichloromethane and methanol extracts of the plant were evaluated for cytotoxic, \u03b1-Chymotrypsin and\r\nUrease inhibition by using in vivo Brine Shrimp lethality bioassay and in vitro enzymatic inhibition assays respectively.\r\nResults: The methanol extract of the plant exhibited significant cytotoxic activity. Out of 30 brine shrimp larvae, 2 (6%), 26 (86%)\r\nand 28 (93%) larvae were survived at concentration of 1000\u03bcg\/ml, 100\u03bcg\/ml and 10\u03bcg\/ml respectively with LD50; 215.837.\r\nSimilarly 21 (70%), 25 (83%), 29 (96%) larvae were survived of dichloromethane plant extract with LD50; 6170.64. The methanol\r\nand dichloromethane extract exhibited 10.50\u00b10.18% and 41.51\u00b10.15% \u03b1-chymotrypsin enzyme inhibition respectively with IC50\r\nvalues of greater than 500 \u03bcmol. The methanol extract showed 24.39\u00b10.21% Urease enzyme inhibition with IC50 values of greater\r\nthan 400 \u03bcmol. While dichloromethane extract has 11.46\u00b10.09% enzyme inhibition with IC50 values of greater than 500 \u03bcmol.\r\nConclusion: The results clearly indicated that Heliotropium dasycarpum has cytotoxic potential and enzyme inhibition properties.\r\nFurther study is needed to screen out antitumor and anti-ulcerative agents.<\/jats:p>","DOI":"10.21010\/ajtcam.v13i6.28","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T10:25:03Z","timestamp":1490610303000},"page":"194-198","source":"Crossref","is-referenced-by-count":5,"title":["CYTOTOXIC, \u03b1-CHYMOTRYPSIN AND UREASE INHIBITION ACTIVITIES OF THE PLANT Heliotropium dasycarpum L."],"prefix":"10.21010","volume":"13","author":[{"given":"Muhammad Abuzar","family":"Ghfaffari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashir Ahmed","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Uzair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khuram","family":"Ashfaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2016,9,29]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4263\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:00:08Z","timestamp":1683536408000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,9,29]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v13i6.28","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}