{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:11:50Z","timestamp":1768270310759,"version":"3.49.0"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new\r\nointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing\r\nactivity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep\r\nsecond-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied\r\nto provide some evidences for its further use.\r\nMaterials and methods: The wound healing potential of this formulation was evaluated by employing a deep\r\nsecond-degree burn rat model and the efficiency was comparatively assessed against a reference ointment \u2013 (1% wt \u2044 wt)\r\nsilver sulfadiazine (SSD). After 28 days, the animals were euthanized and the wounds were removed for transversal\r\nand longitudinal histological studies. Acetic acid-induced writhing in mice was used to evaluate the analgesic activity\r\nand its anti-inflammatory activity was observed in xylene -induced edema in mice.\r\nResults: COBO enhanced the burn wound healing (20.5\u00b11.3 d) as indicated by significant decrease in wound closure\r\ntime compared with the burn control (25.0\u00b12.16 d) (P<\/jats:p>","DOI":"10.21010\/ajtcam.v14i1.8","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T10:58:53Z","timestamp":1490698733000},"page":"62-72","source":"Crossref","is-referenced-by-count":16,"title":["EVALUATION OF EFFECTIVENESS IN A NOVEL WOUND HEALING OINTMENT-CROCODILE OIL BURN OINTMENT"],"prefix":"10.21010","volume":"14","author":[{"given":"Hua-Liang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Tao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Rui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Mei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Xiong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2016,11,23]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3778\/pdf_1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/3778\/pdf_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:53:33Z","timestamp":1683536013000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/3778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,11,23]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i1.8","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}