{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:59:09Z","timestamp":1769277549034,"version":"3.49.0"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: This study aims to examine the protective effect of green tea on the disturbances in oxidative stress and\r\napoptosis related factors, mostly produced due to perinatal lipopolysaccharide (LPS) exposure, that subsequently\r\ninduces liver cell damage.\r\nMaterials and Methods: Anti-free radical, Antioxidant, scavenging, geno-protective, and antiapoptotic activity of\r\naqueous green tea extract (AGTE) were assessed against LPS-induced hepatic dysfunction in newborn-rats. AGTE at\r\ndoses of 100 &amp; 200 mg\/kg was orally administered daily to rat dams, during gestation and lactation.\r\nResults: AGTE was observed to exhibit protective effects by significantly attenuating LPS-induced alterations in\r\nserum AST, ALT, bilirubin, and albumin levels. Significant increase in the total antioxidant capacity (TAC), DNA\r\ncontents, and reduction in nitric oxide (NO) levels were observed in AGTE treated rats comparing LPS-toxicated ones.\r\nAdditionally, AGTE treatment significantly down-regulated apoptotic markers and this effect was directly correlated to\r\nthe degree of hepatic fibrosis. The possible mechanisms of the potential therapeutic-liver protective effect of AGTE\r\ncould be due to free radical scavenging potential and antiapoptotic properties caused by the presence of antioxidant\r\npolyphenolic components in AGTE.\r\nConclusion: We thereby propose, based on our findings, that the anti-free radical and anti-apoptotic inducing\r\nproperties of AGTE active constituents attribute to its functional efficacy as anti-fibrotic agent.<\/jats:p>","DOI":"10.21010\/ajtcam.v14i2.18","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:59:47Z","timestamp":1490785187000},"page":"166-176","source":"Crossref","is-referenced-by-count":6,"title":["GENO PROTECTIVE AND ANTI-APOPTOTIC EFFECT OF GREEN TEA AGAINST PERINATAL LIPOPOLYSACCHARIDE-EXPOSURE INDUCED LIVER TOXICITY IN RAT NEWBORNS"],"prefix":"10.21010","volume":"14","author":[{"given":"Ahmed A.","family":"Allam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami A.","family":"Gabr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamaan","family":"Ajarem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad H.","family":"Alghadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revathi","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy KC","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2017,1,13]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4583\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4583\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:47:54Z","timestamp":1683535674000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,13]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i2.18","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}