{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:04:39Z","timestamp":1761156279210},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Acetaminophen is a common antipyretic drug but at overdose can cause severe hepatotoxicity that may&#x0D;\nfurther develop into liver failure and hepatic centrilobular necrosis in experimental animals and humans. This study&#x0D;\nwas undertaken to assess the ameliorative role of Moringa peregrina leaves extract against acetaminophen toxicity in&#x0D;\nrats.&#x0D;\nMaterials and methods: Induction of hepatotoxicity was done by chronic oral administration of acetaminophen (750&#x0D;\nmg\/kg bwt) for 4 weeks. To study the possible hepatoprotective effect, Moringa peregrina leaves extract (200 mg\/kg&#x0D;\nbwt) or Silymarin (50 mg\/kg bwt) was administered orally, for 4 weeks, along with acetaminophen.&#x0D;\nResults: acetaminophen significantly increased serum liver enzymes and caused oxidative stress, evidenced by&#x0D;\nsignificantly increased tissue malondialdehyde, glutathione peroxidase, hepatic DNA fragmentation, and significant&#x0D;\ndecrease of glutathione and antioxidant enzymes in liver, blood and brain. On the other hand, administration of&#x0D;\nMoringa peregrina leaves extract reversed acetaminophen-related toxic effects through: powerful malondialdehyde&#x0D;\nsuppression, glutathione peroxidase normalization and stimulation of the cellular antioxidants synthesis represented by&#x0D;\nsignificant increase of glutathione, catalase and superoxide dismutase in liver, blood and brain, besides, DNA&#x0D;\nfragmentation was significantly decreased in the liver tissue.&#x0D;\nConclusion: acetaminophen induced oxidative damage can be improved by Moringa peregrina leaves extracttreatment,&#x0D;\ndue to its antioxidant potential.<\/jats:p>","DOI":"10.21010\/ajtcam.v14i2.22","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:59:47Z","timestamp":1490785187000},"page":"206-216","source":"Crossref","is-referenced-by-count":15,"title":["PROTECTIVE EFFECT OF MORINGA PEREGRINA LEAVES EXTRACT ON ACETAMINOPHEN - INDUCED LIVER TOXICITY IN ALBINO RATS."],"prefix":"10.21010","volume":"14","author":[{"given":"Samy Abdelfatah","family":"Abdel Azim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Taha","family":"Abdelrahem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa Mohamed","family":"Said","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alshaimaa","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2017,1,13]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4590\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4590\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:46:49Z","timestamp":1683535609000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,13]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i2.22","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}