{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:04:39Z","timestamp":1761156279928},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Holarrhena floribunda is a plant of wide usage in the Togolese folk medicine. A previous ethnobotanical&#x0D;\nsurvey on the latex plants of the Maritime region of the country revealed that this plant was included in several recipes&#x0D;\ncuring malaria and microbial infections. Therefore, this study aimed to seek for the effectiveness of the ethanolic&#x0D;\nextract of the plant in the treatment of these diseases.&#x0D;\nMethods: The antimicrobial test was performed using the agar well-diffusion and the NCCLS broth microdilution&#x0D;\nmethods, while the in vivo antimalarial activity was evaluated following the four-day suppressive test of Peters. The&#x0D;\nacute toxic effects of the extract were monitored after a single oral dose (5,000 mg\/kg body weight) administration in&#x0D;\nNMRI mice.&#x0D;\nResults: The results indicated that the ethanolic extract of leaves of H. floribunda was active on Staphylococcus aureus&#x0D;\nATCC 29213 and clinical strains of Staphylococcus aureus, Salmonella typhi and Klebsiella pneumoniae with MICs&#x0D;\nranging from 0.62 to 1.25 mg\/mL. The extract also showed significant parasitaemia suppression in a dose-dependent&#x0D;\nmanner. In the acute toxicity assay, the oral administration of the extract to the mice did not affect the relative weight of&#x0D;\nvital organs, and there were no signs of toxicity or death during the study period. The LD50 of the tested extract was&#x0D;\nfound to be greater than 5,000 mg\/kg, indicating its safety.&#x0D;\nConclusion: This study demonstrates the antibacterial and antimalarial activities of leaves of H. floribunda and then,&#x0D;\nsupports its medicinal use in the treatment of microbial infections.<\/jats:p>","DOI":"10.21010\/ajtcam.v14i2.24","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:59:47Z","timestamp":1490785187000},"page":"227-233","source":"Crossref","is-referenced-by-count":9,"title":["THERAPEUTIC POTENTIALS OF ETHANOLIC EXTRACT OF LEAVES OF HOLARRHENA FLORIBUNDA (G. DON) DUR. AND SCHINZ (APOCYNACEAE)"],"prefix":"10.21010","volume":"14","author":[{"given":"Yao Patrick","family":"Hoekou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tchadjobo","family":"Tchacondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simplice Damintoti","family":"Karou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakiswende Serge","family":"Yerbanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elom","family":"Achoribo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ollo","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouyo","family":"Atakpama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komlan","family":"Batawila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8656","published-online":{"date-parts":[[2017,1,13]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4592\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4592\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:46:16Z","timestamp":1683535576000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,13]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i2.24","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}