{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:51:53Z","timestamp":1781841113357,"version":"3.54.5"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: Garcinia hombroniana, known as \u201cmanggis hutan\u201d (jungle mangosteen) in Malaysia, is distributed in\r\ntropical Asia, Borneo, Thailand, Andaman, Nicobar Islands, Vietnam and India. In Malaysia, its ripened crimson sour\r\nfruit rind is used as a seasoning agent in curries and culinary dishes. Its roots and leaves decoction is used against skin\r\ninfections and after child birth. This study aimed to evaluate in vivo hepatoprotective and in vitro cytotoxic activities of\r\n20% methanolic ethyl acetate (MEA) G. hombroniana bark extract.\r\nMaterials and Methods: In hepatoprotective activity, liver damage was induced by treating rats with 1.0 mL carbon\r\ntetrachloride (CCl4)\/kg and MEA extract was administered at a dose of 50, 250 and 500 mg\/kg 24 h before intoxication\r\nwith CCl4. Cytotoxicity study was performed on MCF-7 (human breast cancer), DBTRG (human glioblastoma), PC-3\r\n(human prostate cancer) and U2OS (human osteosarcoma) cell lines. 1H, 13C-NMR (nuclear magnetic resonance), and\r\nIR (infrared) spectral analyses were also conducted for MEA extract.\r\nResults: In hepatoprotective activity evaluation, MEA extract at a higher dose level of 500 mg\/kg showed significant\r\n(p<\/jats:p>","DOI":"10.21010\/ajtcam.v14i2.38","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T10:59:47Z","timestamp":1490785187000},"page":"374-382","source":"Crossref","is-referenced-by-count":9,"title":["IN VIVO CARBON TETRACHLORIDE-INDUCED HEPATOPROTECTIVE AND IN VITRO CYTOTOXIC ACTIVITIES OF GARCINIA HOMBRONIANA (SEASHORE MANGOSTEEN)"],"prefix":"10.21010","volume":"14","author":[{"given":"Nargis","family":"Jamila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Atlas","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadiq Noor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainal Amiruddin","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melati","family":"Khairuddean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnah","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong","family":"Su Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8656","published-online":{"date-parts":[[2017,1,13]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4606\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4606\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:42:24Z","timestamp":1683535344000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,13]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i2.38","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}