{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:50:30Z","timestamp":1793832630274,"version":"4.6.1"},"reference-count":0,"publisher":"African Traditional Herbal Medicine Supporters Initiative (ATHMSI)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Afr J  Tradit Complement Altern Med"],"abstract":"<jats:p>Background: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of\r\ndisability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to\r\nevaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female\r\nSprague-Dawley (SD) rats.\r\nMaterials and Methods: Forty healthy female adult SD rats were separated in to four groups with sham-operated\r\ncontrol with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay\r\nadministrated with 50 mg\/kg b.wt of VA (OVX + 50 VA; n = 10) or 100 mg\/kg b.wt of VA (OVX + 100 VA; n = 10)\r\nfor 12 weeks (post-treatment) after 4 weeks of OVX.\r\nResults: A significant change in the body weight gain was noted in OVX group, while treatment with VA substantially\r\nreverted to normalcy. Meanwhile, the bone mineral density and content (BMD and BMC) were substantially improved\r\non supplementation with VA. Also, the bone turnover markers like calcium (Ca), phosphorous (P), osteocalcin (OC),\r\nalkaline phosphatase (ALP) and deoxypyridinoline (DPD) and inflammatory markers (IL-1\u03b2, IL-6, and TNF-\u03b1) levels\r\nwere markedly attenuated in VA-treated rats. Moreover, the biomechanical stability was greatly ameliorated with VA\r\nadministration. Both the dose of VA showed potent anti-osteoporotic activity, but VA 100 mg showed highest\r\nprotective effects as compared with 50 mg of VA.\r\nConclusion: Based on the outcome, we concluded that VA 100 showed better anti-osteoporotic activity by improving\r\nBMD and BMC as well as biomechanical stability and therefore used as an alternative therapy for treating\r\npostmenopausal osteoporosis.<\/jats:p>","DOI":"10.21010\/ajtcam.v14i4.4","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T11:33:01Z","timestamp":1496748781000},"page":"31-38","source":"Crossref","is-referenced-by-count":19,"title":["PROTECTIVE EFFECT OF VANILLIC ACID ON OVARIECTOMY-INDUCED OSTEOPOROSIS IN RATS"],"prefix":"10.21010","volume":"14","author":[{"given":"Yong Gui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang Bo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8656","published-online":{"date-parts":[[2017,6,5]]},"container-title":["African Journal of Traditional, Complementary and Alternative Medicines"],"original-title":[],"link":[{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4715\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/download\/4715\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T09:02:44Z","timestamp":1683363764000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.athmsi.org\/index.php\/ajtcam\/article\/view\/4715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,6,5]]}},"URL":"https:\/\/doi.org\/10.21010\/ajtcam.v14i4.4","relation":{},"ISSN":["2505-0044","0189-6016"],"issn-type":[{"value":"2505-0044","type":"electronic"},{"value":"0189-6016","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}