{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:35:39Z","timestamp":1782934539311,"version":"3.54.5"},"reference-count":42,"publisher":"American Public Health Association","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Public Health"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p> Objectives. To examine prevalence of low- and high-grade cervical lesions over time in a large cohort of US female adolescents and women. <\/jats:p><jats:p> Methods. We used health care claims data from 9 million privately insured female patients aged 15 to 39 years to estimate annual prevalence of cytologically detected cervical low-grade (LSIL) and high-grade squamous intraepithelial lesions (HSIL) and high-grade histologically detected cervical intraepithelial neoplasia grades 2 and 3 (CIN2+) during 2007 through 2014. We restricted analyses to those who received cervical cancer screening in a given calendar year. <\/jats:p><jats:p> Results. Prevalence of HSIL and CIN2+ decreased significantly for those aged 15 to 19 years. Average annual percent change in prevalence in this group during 2007 through 2014 for HSIL and CIN2+ was \u22128.3% and \u221214.4%, respectively (P\u2009&lt;\u2009.001 for both estimates). Prevalence of HSIL and CIN2+ also decreased significantly for women aged 20 to 24 years. No decreases were seen in women aged 25 to 39 years. <\/jats:p><jats:p> Conclusions. Decreases in high-grade lesions reflected their greater association with human papillomavirus types 16 and 18, compared with low-grade lesions, providing ecological evidence of population effectiveness of human papillomavirus vaccination among young, privately insured women. <\/jats:p>","DOI":"10.2105\/ajph.2016.303472","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T19:42:54Z","timestamp":1476387774000},"page":"2211-2218","source":"Crossref","is-referenced-by-count":46,"title":["Ecological Association of Human Papillomavirus Vaccination with Cervical Dysplasia Prevalence in the United States, 2007\u20132014"],"prefix":"10.2105","volume":"106","author":[{"given":"Elaine W.","family":"Flagg","sequence":"first","affiliation":[{"name":"At the time of the study, all of the authors were with the Division of STD Prevention; National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention; Centers for Disease Control and Prevention; Atlanta, 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