{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:31:25Z","timestamp":1791653485221,"version":"4.3.4"},"reference-count":33,"publisher":"American Public Health Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Public Health"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Hepatitis C virus (HCV) infection remains an important cause of morbidity and mortality throughout the world, leading to serious health problems among those who are chronically infected. Since 1992, the Centers for Disease Control and Prevention has been collecting data on the incidence of HCV infection in the United States. In 2018, more than 50\u2009000 individuals were estimated to have acute HCV infection.<\/jats:p><jats:p>The most recently reported data on the prevalence of infection indicate that approximately 2.4 million people are living with hepatitis C in the United States. Transmission of HCV occurs predominantly through sharing contaminated equipment for injecting drugs.<\/jats:p><jats:p>Two major events have had a significant impact on the incidence and prevalence of hepatitis C in the past few decades: the US opioid crisis and the discovery of curative treatments for HCV infection. To better understand the impact of these events, we examine reported trends in the incidence and prevalence of infection.<\/jats:p>","DOI":"10.2105\/ajph.2020.306149","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T20:00:45Z","timestamp":1616097645000},"page":"949-955","source":"Crossref","is-referenced-by-count":44,"title":["The Changing Epidemiology of Hepatitis C Virus Infection in the United States During the Years 2010 to 2018"],"prefix":"10.2105","volume":"111","author":[{"given":"Deborah","family":"Holtzman","sequence":"first","affiliation":[{"name":"Deborah Holtzman was previously with the Division of Viral Hepatitis, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, GA. She was retired at the time the study was undertaken and the article was prepared. Alice K. Asher is with the National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC. At the time of the study, Sarah Schillie was with the Division of Viral Hepatitis, National Center for HIV\/AIDS, Viral..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice K.","family":"Asher","sequence":"additional","affiliation":[{"name":"Deborah Holtzman was previously with the Division of Viral Hepatitis, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, GA. She was retired at the time the study was undertaken and the article was prepared. Alice K. Asher is with the National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC. At the time of the study, Sarah Schillie was with the Division of Viral Hepatitis, National Center for HIV\/AIDS, Viral..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schillie","sequence":"additional","affiliation":[{"name":"Deborah Holtzman was previously with the Division of Viral Hepatitis, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, GA. She was retired at the time the study was undertaken and the article was prepared. Alice K. Asher is with the National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC. 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