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In fact, while total opioid prescribing has leveled off or reduced in many jurisdictions, population-level harms from opioids have continued to increase dramatically.<\/jats:p><jats:p>We attribute this failure partly to a poor recognition of the epistemic and ethical complexities at the interface of clinical and population health. We draw on a framework of knowledge networks in wicked problems to identify 3 strategies to help navigate these complexities: (1) designing and evaluating clinically focused interventions as complex interventions, (2) reformulating evidence to make population health dynamics apparent, and (3) appealing to the inseparability of facts and values to support decision-making in uncertainty.<\/jats:p><jats:p>We advocate that applying these strategies will better equip clinically focused interventions as complements to structural and public health interventions to achieve the desired beneficial population health effects. (Am J Public Health. 2022;112(S1):S56\u2013S65. https:\/\/doi.org\/10.2105\/AJPH.2021.306500 )<\/jats:p>","DOI":"10.2105\/ajph.2021.306500","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T21:01:11Z","timestamp":1644526871000},"page":"S56-S65","source":"Crossref","is-referenced-by-count":7,"title":["Chronic Pain and Opioid Prescribing: Three Ways for Navigating Complexity at the Clinical\u2012Population Health Interface"],"prefix":"10.2105","volume":"112","author":[{"given":"Abhimanyu","family":"Sud","sequence":"first","affiliation":[{"name":"Abhimanyu Sud is with the Department of Family and Community Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Canada. Daniel Z. Buchman is with Centre for Addiction and Mental Health and Dalla Lana School of Public Health, Toronto. Andrea D. Furlan is with the Institute for Work and Health and Department of Medicine, University of Toronto. Peter Selby is with the Centre for Addiction and Mental Health and Department of Family and Community Medicine, Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Z.","family":"Buchman","sequence":"additional","affiliation":[{"name":"Abhimanyu Sud is with the Department of Family and Community Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Canada. Daniel Z. Buchman is with Centre for Addiction and Mental Health and Dalla Lana School of Public Health, Toronto. Andrea D. Furlan is with the Institute for Work and Health and Department of Medicine, University of Toronto. Peter Selby is with the Centre for Addiction and Mental Health and Department of Family and Community Medicine, Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"Furlan","sequence":"additional","affiliation":[{"name":"Abhimanyu Sud is with the Department of Family and Community Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Canada. Daniel Z. Buchman is with Centre for Addiction and Mental Health and Dalla Lana School of Public Health, Toronto. Andrea D. Furlan is with the Institute for Work and Health and Department of Medicine, University of Toronto. Peter Selby is with the Centre for Addiction and Mental Health and Department of Family and Community Medicine, Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Selby","sequence":"additional","affiliation":[{"name":"Abhimanyu Sud is with the Department of Family and Community Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Canada. Daniel Z. Buchman is with Centre for Addiction and Mental Health and Dalla Lana School of Public Health, Toronto. Andrea D. Furlan is with the Institute for Work and Health and Department of Medicine, University of Toronto. Peter Selby is with the Centre for Addiction and Mental Health and Department of Family and Community Medicine, Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl M.","family":"Spithoff","sequence":"additional","affiliation":[{"name":"Abhimanyu Sud is with the Department of Family and Community Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Canada. Daniel Z. Buchman is with Centre for Addiction and Mental Health and Dalla Lana School of Public Health, Toronto. Andrea D. Furlan is with the Institute for Work and Health and Department of Medicine, University of Toronto. 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