{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:06:10Z","timestamp":1762067170436},"reference-count":18,"publisher":"American Public Health Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Public Health"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p> The unusual resistance of the \"unconventional viruses\" to inactivation by the commonly used disinfectants has led to a high degree of apprehension regarding patients with any form of dementia. The rapid adaptation of a newly acquired isolate of the agent of Creutzfeldt-Jakob Disease (CJD) to mice made possible this large scale study of its heat and chemical stability. The agent showed a decrease in titer of approximately two logs following incubation at 80 degrees C for 30 minutes with no additional loss at 80 degrees C for up to 500 minutes. There was greater than a three log decrease in titer at 100 degrees C for 30 minutes and temperatures of 115 degrees and 130 degrees C completely inactivated the agent. Treatment with sodium hypochlorite at three concentrations (0.33 per cent, 0.66 per cent and 1.31 per cent) showed inactivation of greater than 99 per cent at each. Crude agent preparations were not inactivated by sodium dodecylsulfate at detergent to protein ratios up to 4:1. These results suggest that those hospital supplies which resist autoclaving may be adequately disinfected by autoclaving for at least 30 minutes. Treatment of surfaces with solutions of sodium hypochlorite (household bleach) at concentrations of 15 to 25 per cent is also effective. Detergent treatment of contaminated surfaces or materials is inadequate for proper decontamination. <\/jats:p>","DOI":"10.2105\/ajph.73.6.661","type":"journal-article","created":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T05:16:35Z","timestamp":1227762995000},"page":"661-665","source":"Crossref","is-referenced-by-count":25,"title":["Conditions for the chemical and physical inactivation of the K. Fu. strain of the agent of Creutzfeldt-Jakob disease."],"prefix":"10.2105","volume":"73","author":[{"given":"A S","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Inderlied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Kingsbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"844","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3897.1023"},{"key":"p_2","unstructured":"Gibbs CJ, Gajdusek DC: Biology of kuru and Creutzfeldt-Jakob Disease. In: Zeman W, Lennette EH, Brunson JG (eds): Slow Virus Diseases. Baltimore: Williams and Wilkins Company, 1973, pp 39-48."},{"key":"p_3","unstructured":"Gajdusek DC: Creutzfeldt-Jakob disease: Patterns of worldwide occurrence and significance of familal and sporadic clustering. In Dejong RN, Sugar 0 (eds): The Year Book of Neurology and Neurosurgery. Chicago: Year Book Medical Publishers, Inc., 1980, pp 84-85."},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.190.4214.571"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050616"},{"key":"p_6","doi-asserted-by":"crossref","unstructured":"Kingsbury DT, Smeltzer DA, Amyx H, Gibbs CJ Jr, Gajdusek DC: Evidence for an unconventional virus in mouse adapted Creutzfeldt-Jakob disease. 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New York: American Elsevier Publishing Company, Inc., 1976, pp 243-266."},{"key":"p_11","first-page":"581","volume":"27","author":"Reed LJ","year":"1938","journal-title":"Am J Hyg"},{"key":"p_12","first-page":"118","volume":"59","author":"Clarke NA","year":"1954","journal-title":"Am J Hyg"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.5.713"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2984"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062107"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700056137"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700056162"}],"container-title":["American Journal of Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ajph.aphapublications.org\/doi\/pdf\/10.2105\/AJPH.73.6.661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T19:08:07Z","timestamp":1652123287000},"score":1,"resource":{"primary":{"URL":"https:\/\/ajph.aphapublications.org\/doi\/full\/10.2105\/AJPH.73.6.661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["10.2105\/AJPH.73.6.661"],"URL":"https:\/\/doi.org\/10.2105\/ajph.73.6.661","relation":{},"ISSN":["0090-0036","1541-0048"],"issn-type":[{"value":"0090-0036","type":"print"},{"value":"1541-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}