{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:15:58Z","timestamp":1767651358505},"reference-count":29,"publisher":"American Public Health Association","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Public Health"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:p> BACKGROUND: DNA prenatal diagnosis for cystic fibrosis (CF) has been available for parents of affected children since late 1985. METHODS: Using anonymous questionnaires, we surveyed 395 parents of children with CF at 12 New England CF centers with regard to 12 maternal or family situations and 11 fetal characteristics; 271 (68%) responded. RESULTS: The majority supported legal abortion in the first trimester for all 23 situations; 58% would abort for severe mental retardation (MR), 40% would abort for a genetic disorder leading to death before age five years, 41% for a child bedridden for life, 35% for moderate MR, 20% for CF and 17% for a severe incurable disorder starting at age 40 years. Few would abort for a disorder starting at age 60 years, for genetic susceptibility to alcoholism or for sex selection. Variables most strongly related to abortion for CF were attitudes of spouse, respondent's siblings, and CF doctor toward abortion for CF as well as infrequent attendance at religious services. CONCLUSIONS: Prenatal diagnosis may not reduce substantially the number of CF births to parents of CF children because most do not accept abortion for CF. <\/jats:p>","DOI":"10.2105\/ajph.81.8.992","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T13:17:08Z","timestamp":1227964628000},"page":"992-996","source":"Crossref","is-referenced-by-count":44,"title":["Attitudes toward abortion among parents of children with cystic fibrosis."],"prefix":"10.2105","volume":"81","author":[{"given":"D C","family":"Wertz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Rosenfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Janes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Erbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"844","reference":[{"key":"p_1","unstructured":"ElkinsTE, Stoval TG, WilroyS, DacusJV. Attitudes of mothers of children with Down syndrome concerning amniocentesis, abortion, and prenatal genetic counseling techniques. Obstet GynecoL 1986;68:181-184."},{"key":"p_2","unstructured":"Lubs ML, Falk RF. Response to prospective genetic counseling in severe X-linked disorders. In. Lubs HA, de la Cruz F, eds: Genetic Counseling. 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The centralized prenatal genetics screening program of New York City: Ill, the first 7,000 cases.Am JMed Genet. 1985;20:369-384.","DOI":"10.1002\/ajmg.1320200221"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.77.3.288"},{"key":"p_14","unstructured":"Boat TF, Welsh MJ, Beaudet AL. Cystic fibrosis. In: Scriver CF, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inhenited Disease, 6th ed. Vol. II. New York: McGraw-Hill; 1989:2649-2680."},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92860-0"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91553-9"},{"key":"p_17","doi-asserted-by":"crossref","unstructured":"Evers-Kiebooms G, Denayer L, Van den Berghe H. A child with cystic fibrosis: II, subsequent family planning decisions, reproduction and use of prenatal diagnosis. CGn Genet. 1990;37:207-215.","DOI":"10.1111\/j.1399-0004.1990.tb03504.x"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1990.tb03613.x"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282551"},{"key":"p_20","unstructured":"Elias S, Annas GJ. Reproductive Genetics and the Law. Chicago, Ill: Yearbook Publishers; 1989."},{"key":"p_21","unstructured":"Evans MI, Fletcher JC, Drugan A, Bottoms SF, Platt LD. Ethics of selective termination: a survey of physicians of the American Society of Human Genetics (ASHG).AmrJHwn Genet. 1988;43:A233."},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090302"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.2307\/3562739"},{"key":"p_24","doi-asserted-by":"crossref","unstructured":"Kyle D, Cummins C, Evans S. Factors affecting the uptake of screening for neural tube defect. Br J Obstet GynaecoL 1988; 95:560-564.","DOI":"10.1111\/j.1471-0528.1988.tb09483.x"},{"key":"p_25","unstructured":"Luker K. Abortion and the Politics of Motherhood Berkeley, Calif: University of California Press; 1983:158-215."},{"key":"p_27","unstructured":"Cystic Fibrosis Foundation. National Registry of Cystic Fibrosis Patients. Rockville, Md; 1990."},{"key":"p_28","doi-asserted-by":"crossref","unstructured":"Colten HR. Screening for cystic fibrosis: public policy and personal choices. NEngi JMed 1990;322:328-329.","DOI":"10.1056\/NEJM199002013220510"},{"key":"p_29","unstructured":"Kaback M, Zippin D, Boyd P, Cantor R. Attitudes toward prenatal diagnosis of cystic fibrosis among parents of affected children. In: Lawson D, ed. Cystic Fibrosis: tional Cystic Fibrosir Congress, June 9-15, Honwons. Proceedings of the 9th Interna-1984. Chichester, N.Y.: Wiley; 1984:15-28."},{"key":"p_30","first-page":"115","volume":"23","author":"Denning CR","year":"1987","journal-title":"Birth Defects."}],"container-title":["American Journal of Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ajph.aphapublications.org\/doi\/pdf\/10.2105\/AJPH.81.8.992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T19:17:00Z","timestamp":1652123820000},"score":1,"resource":{"primary":{"URL":"https:\/\/ajph.aphapublications.org\/doi\/full\/10.2105\/AJPH.81.8.992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.2105\/AJPH.81.8.992"],"URL":"https:\/\/doi.org\/10.2105\/ajph.81.8.992","relation":{},"ISSN":["0090-0036","1541-0048"],"issn-type":[{"value":"0090-0036","type":"print"},{"value":"1541-0048","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}