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An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men. CONCLUSIONS: Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans. <\/jats:p>","DOI":"10.2105\/ajph.88.8.1208","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T13:30:23Z","timestamp":1227965423000},"page":"1208-1212","source":"Crossref","is-referenced-by-count":16,"title":["Serum ascorbic acid and other correlates of gallbladder disease among US adults."],"prefix":"10.2105","volume":"88","author":[{"given":"J A","family":"Simon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E S","family":"Hudes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"844","reference":[{"issue":"3","key":"p_1","first-page":"1","volume":"10","year":"1992","journal-title":"NIH Consens Statement."},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01073011"},{"key":"p_3","first-page":"735","volume":"20","author":"Trotman BW","year":"1975","journal-title":"Am JDigDis."},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91972-W"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4074.702"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BF01934031"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(77)80081-8"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19780128"},{"key":"p_9","first-page":"137","volume":"23","author":"Ginter E","year":"1982","journal-title":"Int J Vitam Nutr Res."},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(93)90132-A"},{"key":"p_11","unstructured":"National Center for Health Statistics. 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