{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:14:40Z","timestamp":1780636480528,"version":"3.54.1"},"reference-count":15,"publisher":"American Public Health Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Public Health"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p> Objectives. This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) among Filipino laborers in Taiwan. <\/jats:p><jats:p> Methods. Forty-six SJS\/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. <\/jats:p><jats:p> Results. The odds ratio for development of SJS\/TEN was 9.5 (95% confidence interval [CI] = 3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS\/TEN was found with an increasing level of exposure to metronidazole. <\/jats:p><jats:p> Conclusions. This outbreak highlights the risk of SJS\/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures. <\/jats:p>","DOI":"10.2105\/ajph.93.3.489","type":"journal-article","created":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:04:35Z","timestamp":1228176275000},"page":"489-492","source":"Crossref","is-referenced-by-count":43,"title":["Outbreak of Stevens-Johnson Syndrome\/Toxic Epidermal Necrolysis Associated With Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan"],"prefix":"10.2105","volume":"93","author":[{"given":"Kow-Tong","family":"Chen","sequence":"first","affiliation":[{"name":"Kow-Tong Chen is with the Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taiwan, Republic of China. Shiing-Jer Twu is with the Center for Disease Control, Department of Health, Taiwan. Hong-Jen Chang is with the Department of Health, Taiwan. Ruey-Shiung Lin is with the Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiing-Jer","family":"Twu","sequence":"additional","affiliation":[{"name":"Kow-Tong Chen is with the Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taiwan, Republic of China. Shiing-Jer Twu is with the Center for Disease Control, Department of Health, Taiwan. Hong-Jen Chang is with the Department of Health, Taiwan. Ruey-Shiung Lin is with the Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Kow-Tong Chen is with the Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taiwan, Republic of China. Shiing-Jer Twu is with the Center for Disease Control, Department of Health, Taiwan. Hong-Jen Chang is with the Department of Health, Taiwan. Ruey-Shiung Lin is with the Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey-Shiung","family":"Lin","sequence":"additional","affiliation":[{"name":"Kow-Tong Chen is with the Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taiwan, Republic of China. Shiing-Jer Twu is with the Center for Disease Control, Department of Health, Taiwan. Hong-Jen Chang is with the Department of Health, Taiwan. Ruey-Shiung Lin is with the Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"844","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"R4","unstructured":"Tyson R, Walker J. An unusual bullous eruption. 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