{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:52:30Z","timestamp":1777096350434,"version":"3.51.4"},"reference-count":21,"publisher":"Korean Society of Otorhinolaryngology-Head and Neck Surgery","issue":"4","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A3B03030968"],"award-info":[{"award-number":["2017R1D1A3B03030968"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-ceo.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Otorhinolaryngol"],"published-print":{"date-parts":[[2021,11,30]]},"abstract":"<jats:p>Objectives. The aims of this study were to investigate the effect of intratympanic injection of isosorbide on the vestibular function in animal models with endolymphatic hydrops and to find a new treatment option for the acute onset of vertigo in M\u00e9ni\u00e8re\u2019s disease (MD).Methods. Seventy male guinea pigs were used. Intratympanic injection of isosorbide (IT-ISB) was applied. The animals were divided into three study groups, namely the control, chronic hydrops model, and acute hydrops model groups. The intracochlear drug concentration was measured using high-performance liquid chromatography (HPLC). Vestibular function was analyzed using an animal rotator test with bidirectional sinusoidal harmonic acceleration (SHA) before and after IT-ISB. The histological change was also investigated.Results. ISB successfully permeated the perilymph through the round window membrane (RWM) at all three different concentrations of IT-ISB (25%, 50%, and 100%). In the chronic hydrops model, while IT-ISB histologically induced a reduction of endolymphatic hydrops, vestibular function was unchanged. In the acute hydrops model, no endolymphatic hydrops was histologically observed, and vestibular symmetry was also preserved after IT-ISB.Conclusion. ISB passed through the RWM into the perilymphatic space even at the lower concentrations. IT-ISB histologically reduced the hydrops in the chronic model and preserved the symmetrical vestibular function in the acute model. IT-ISB could be a treatment candidate for the acute attack of vertigo in MD.<\/jats:p>","DOI":"10.21053\/ceo.2019.02040","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:35:20Z","timestamp":1602808520000},"page":"367-373","update-policy":"https:\/\/doi.org\/10.21053\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Intratympanic Injection of Isosorbide on the Vestibular Function of Animal Models of Endolymphatic Hydrops"],"prefix":"10.21053","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-1403","authenticated-orcid":true,"given":"Minbum","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-6424","authenticated-orcid":true,"given":"So 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