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Chronic tinnitus has been anatomically and phenomenologically separated into three pathways: a lateral \u201csound\u201d pathway, a medial \u201csuffering\u201d pathway, and a descending noise-canceling pathway. Here, the triple network model is proposed as a unifying framework common to neuropsychiatric disorders. It proposes that abnormal interactions among three cardinal networks\u2014the self-representational default mode network, the behavioral relevance-encoding salience network and the goal-oriented central executive network\u2014underlie brain disorders. Tinnitus commonly leads to negative cognitive, emotional, and autonomic responses, phenomenologically expressed as tinnitus-related suffering, processed by the medial pathway. This anatomically overlaps with the salience network, encoding the behavioral relevance of the sound stimulus. Chronic tinnitus can also become associated with the self-representing default mode network and becomes an intrinsic part of the self-percept. This is likely an energy-saving evolutionary adaptation, by detaching tinnitus from sympathetic energy-consuming activity. Eventually, this can lead to functional disability by interfering with the central executive network. In conclusion, these three pathways can be extended to a triple network model explaining all tinnitus-associated comorbidities. This model paves the way for the development of individualized treatment modalities.<\/jats:p>","DOI":"10.21053\/ceo.2022.00815","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T21:09:42Z","timestamp":1657487382000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.21053\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Tinnitus and the Triple Network Model: A Perspective"],"prefix":"10.21053","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-268X","authenticated-orcid":true,"given":"Dirk","family":"De 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