{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:30:06Z","timestamp":1791772206422,"version":"4.3.4"},"reference-count":102,"publisher":"Korean Society of Otorhinolaryngology-Head and Neck Surgery","issue":"4","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-ceo.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Otorhinolaryngol"],"published-print":{"date-parts":[[2025,11,30]]},"abstract":"<jats:p>Objectives. This systematic review was performed to investigate the co-occurrence of otologic disorders and benign paroxysmal positional vertigo (BPPV).Methods. Searches were conducted in PubMed and Web of Science. The review included all original English-language studies\u2014ranging from full-text clinical trials to case reports\u2014enrolling participants aged \u226518 years. Articles were classified into two groups: group 1 comprised studies reporting otologic disorders in patients diagnosed with BPPV; group 2 comprised studies reporting instances of BPPV among patients with otologic disorders. The frequency of each condition was analyzed using descriptive statistics. Meta-analyses were performed using a random-effects model to estimate overall prevalence in both groups.Results. The initial search yielded 3,407 records, of which 68 articles were included in the analysis. In group 1 (19 studies), 11.4% of patients with BPPV (932\/8,157) had co-occurring otologic disorders. Sudden sensorineural hearing loss (present in 11.9% of patients in relevant included studies) and acute unilateral vestibulopathy\/vestibular neuritis (5.0%) were most frequently reported. Meta-analysis produced pooled prevalence rates of 11.8% (95% CI, 3.1%\u201335.7%) for sudden sensorineural hearing loss and 6.5% (95% CI, 3.7%\u201311.2%) for acute unilateral vestibulopathy\/vestibular neuritis. In group 2 (49 studies), 9.7% of patients with otologic disorders (1,106\/11,457) experienced concurrent BPPV, with Meni\u00e8re\u2019s disease exhibiting the highest rate of concurrence (10.2%). Meta-analyses showed pooled prevalence rates of 10.4% (95% CI, 6.2%\u201316.8%) for acute unilateral vestibulopathy\/vestibular neuritis and 9.1% (95% CI, 4%\u201319.1%) for Meni\u00e8re\u2019s disease.Conclusion. The co-occurrence of otologic disorders and BPPV is prevalent. These findings underscore the need for mutual clinical screening and may inform understanding of the etiologies underlying BPPV.<\/jats:p>","DOI":"10.21053\/ceo.2025-00030","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T01:44:22Z","timestamp":1749433462000},"page":"326-338","update-policy":"https:\/\/doi.org\/10.21053\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Co-occurrence of Otologic Disorders and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis"],"prefix":"10.21053","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-3967","authenticated-orcid":true,"given":"Mustafa","family":"Karabulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-5280","authenticated-orcid":true,"given":"Sevgi","family":"Kutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-4063","authenticated-orcid":true,"given":"Wolfgang","family":"Viechtbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4786-3164","authenticated-orcid":true,"given":"Ali","family":"Melliti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-8045","authenticated-orcid":true,"given":"Cem","family":"Me\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-7728","authenticated-orcid":true,"given":"Alfarghal","family":"Mohamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-1859","authenticated-orcid":true,"given":"Osman Nuri","family":"\u00d6zgirgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-8885","authenticated-orcid":true,"given":"Anita","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-8224","authenticated-orcid":true,"given":"Herman","family":"Kingma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-8668","authenticated-orcid":true,"given":"Raymond","family":"van de Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1894","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.100420"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10314-7"},{"key":"ref3","first-page":"151","volume-title":"The mechanics of benign paroxysmal vertigo","author":"Hall","year":"1979"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770030767020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04529-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2010.6.2.51"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199209000-00006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3233\/ves-150553"},{"key":"ref9","first-page":"1382196","volume-title":"Residual dizziness after BPPV management: exploring pathophysiology and treatment beyond canalith repositioning maneuvers","author":"Ozgirgin","year":"2024"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000603"},{"key":"ref11","first-page":"565","volume-title":"Misdiagnosing dizzy patients: common pitfalls in clinical practice","author":"Kerber","year":"2015"},{"key":"ref12","first-page":"625776","volume-title":"Two symptoms strongly suggest benign paroxysmal positional vertigo in a dizzy patient","author":"van Dam","year":"2021"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/709469"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245726"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"ref16","first-page":"2057","volume-title":"Evidence-based guideline development in the Netherlands: the EBRO platform","author":"Burgers","year":"2004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn204"},{"key":"ref23","volume-title":"","year":"2021"},{"key":"ref24","first-page":"1","volume-title":"Conducting meta-analyses in R with the metafor package","author":"Viechtbauer","year":"2010"},{"key":"ref25","first-page":"1417","volume-title":"Refractory positional vertigo with apogeotropic horizontal nystagmus after labyrinthitis: surgical treatment and identification of dysmorphic ampullae","author":"Ahmed","year":"2015"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24260"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200107000-00021"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/02703181.2019.1667471"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212101011"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2484-2"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25797"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.04.006"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100x-1549"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.634782"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2020.00360"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2022.21417"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.08.021"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/s1808-8694(15)30102-6"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-023-00456-6"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00022"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2147\/prom.s370287"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-018-1449-6"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309128074"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2012.754996"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199705000-00010"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244473.84246.76"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309128062"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13185381"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1177\/014556131109000114"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.8.1024"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.593551"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811421733"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215106000958"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000000899"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3233\/ves-200703"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.06.905"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.199"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000002084"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000035480"},{"key":"ref60","first-page":"3672","volume-title":"Clinical analysis of benign paroxysmal positional vertigo secondary to Meniere\u2019s disease","author":"Li","year":"2010"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.877777"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000004287"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3233\/ves-2005-15305"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903311278"},{"key":"ref65","first-page":"38","volume-title":"The outcome of the canalith repositioning procedure for benign paroxysmal positional vertigo: are there any characteristic features of treatment failure cases","author":"Monobe","year":"2001"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890200035008"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200008000-00031"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1080\/713792589"},{"key":"ref69","first-page":"1104","volume-title":"Benign paroxysmal positional vertigo in patients with Meniere\u2019s disease treated with intratympanic gentamycin","author":"Perez","year":"2002"},{"key":"ref70","first-page":"131","volume-title":"Benign paroxysmal positional vertigo in the first acute attack of Meniere\u2019s disease","author":"Psillas","year":"2011"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-5101.2003.00705.x"},{"key":"ref72","first-page":"191","volume-title":"Prevalence of vestibulopathy in benign paroxysmal positional vertigo patients with and without prior otologic history","author":"Roberts","year":"2005"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.09.001"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2020.1813327"},{"key":"ref75","first-page":"137","volume-title":"Comorbid benign paroxysmal positional vertigo in idiopathic sudden sensorineural hearing loss: an ominous sign for hearing recovery","author":"Song","year":"2012"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2043-2"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.936624"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319871234"},{"key":"ref79","first-page":"1620","volume-title":"Two common second causes of dizziness in patients with Meniere\u2019s disease","author":"van Esch","year":"2016"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2023.22703"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817706491"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.17.7.3"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.3233\/ves-180638"},{"key":"ref84","first-page":"547","volume-title":"Successful repositioning procedure for benign paroxysmal positional vertigo after stapedotomy","author":"Zubcic","year":"2022"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100145608"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e3181b0fd5d"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08928-y"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1080\/14670100.2019.1662978"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e318299b376"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3988-3"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e318064e8d4"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419845014"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-11-2"},{"key":"ref94","first-page":"69","volume-title":"The dizzy patient: consider a second diagnosis","author":"van Leeuwen","year":"2017"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.08.022"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63882-3"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.3.755"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00108"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.37.3.371"},{"key":"ref100","first-page":"1585","volume-title":"Ductus reuniens and its possible role in Meniere\u2019s disease","author":"Hornibrook","year":"2021"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2016.2906"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1179\/106698110x12640740712699"}],"container-title":["Clinical and Experimental Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-ceo.org\/upload\/pdf\/ceo-2025-00030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-ceo.org\/journal\/view.php?doi=10.21053\/ceo.2025-00030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-ceo.org\/upload\/pdf\/ceo-2025-00030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:05:32Z","timestamp":1761609932000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-ceo.org\/journal\/view.php?doi=10.21053\/ceo.2025-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":102,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.21053\/ceo.2025-00030","relation":{},"ISSN":["1976-8710","2005-0720"],"issn-type":[{"value":"1976-8710","type":"print"},{"value":"2005-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]},"assertion":[{"value":"2025-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}