{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:38:05Z","timestamp":1787755085995,"version":"build-2784847793"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2016,11,16]]},"DOI":"10.2106\/jbjs.15.00937","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T22:31:23Z","timestamp":1479421883000},"page":"1924-1932","source":"Crossref","is-referenced-by-count":15,"title":["Intraosseous Injection of Simvastatin in Poloxamer 407 Hydrogel Improves Pedicle-Screw Fixation in Ovariectomized Minipigs"],"prefix":"10.2106","volume":"98","author":[{"given":"X.","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.S.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"bib1-20210131","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrrheum.2011.217","article-title":"Osteoporosis, frailty and fracture: implications for case finding and therapy","volume":"8","author":"van den Bergh","year":"2012","journal-title":"Nat Rev Rheumatol."},{"issue":"2","key":"bib2-20210131","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2106\/JBJS.N.00654","article-title":"Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis","volume":"97","author":"Virdi","year":"2015","journal-title":"J Bone Joint Surg Am."},{"issue":"18","key":"bib3-20210131","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.2106\/JBJS.K.00344","article-title":"Sclerostin antibody increases bone volume and enhances implant fixation in a rat model","volume":"94","author":"Virdi","year":"2012","journal-title":"J Bone Joint Surg Am."},{"issue":"7","key":"bib4-20210131","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1359\/jbmr.2002.17.7.1139","article-title":"Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography","volume":"17","author":"Borah","year":"2002","journal-title":"J Bone Miner Res."},{"issue":"1","key":"bib5-20210131","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11914-014-0191-6","article-title":"Local strategies to prevent and treat osteoporosis","volume":"12","author":"Torstrick","year":"2014","journal-title":"Curr Osteoporos Rep."},{"issue":"18","key":"bib6-20210131","doi-asserted-by":"crossref","first-page":"E1210","DOI":"10.1097\/BRS.0b013e318205e3af","article-title":"Biomechanical evaluation of a novel fenestrated pedicle screw augmented with bone cement in osteoporotic spines","volume":"36","author":"Par\u00e9","year":"2011","journal-title":"Spine (Phila Pa 1976)."},{"issue":"23","key":"bib7-20210131","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1097\/BRS.0b013e318184e750","article-title":"Augmentation of pedicle screw fixation strength using an injectable calcium sulfate cement: an in vivo study","volume":"33","author":"Yi","year":"2008","journal-title":"Spine (Phila Pa 1976)."},{"issue":"2","key":"bib8-20210131","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/17453670610045984","article-title":"Calcium phosphate cement for augmentation did not improve results after internal fixation of displaced femoral neck fractures: a randomized study of 118 patients","volume":"77","author":"Mattsson","year":"2006","journal-title":"Acta Orthop."},{"issue":"1","key":"bib9-20210131","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2106\/JBJS.K.00668","article-title":"Intraosseous injection of rhBMP-2\/calcium phosphate matrix improves bone structure and strength in the proximal aspect of the femur in chronic ovariectomized nonhuman primates","volume":"95","author":"Seeherman","year":"2013","journal-title":"J Bone Joint Surg Am."},{"issue":"19","key":"bib10-20210131","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.2106\/JBJS.K.00523","article-title":"rhBMP-2\/calcium phosphate matrix induces bone formation while limiting transient bone resorption in a nonhuman primate core defect model","volume":"94","author":"Seeherman","year":"2012","journal-title":"J Bone Joint Surg Am."},{"issue":"2","key":"bib11-20210131","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2106\/JBJS.H.01732","article-title":"rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model","volume":"92","author":"Seeherman","year":"2010","journal-title":"J Bone Joint Surg Am."},{"issue":"1","key":"bib12-20210131","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bone.2011.10.011","article-title":"Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits","volume":"50","author":"Qi","year":"2012","journal-title":"Bone."},{"issue":"21","key":"bib13-20210131","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1016\/j.biomaterials.2014.03.069","article-title":"Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats","volume":"35","author":"Alghamdi","year":"2014","journal-title":"Biomaterials."},{"issue":"4","key":"bib14-20210131","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/jbmr.2000.15.4.613","article-title":"Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib","volume":"15","author":"Mashiba","year":"2000","journal-title":"J Bone Miner Res."},{"issue":"1","key":"bib15-20210131","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bone.2010.10.159","article-title":"Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don\u2019t know","volume":"49","author":"Allen","year":"2011","journal-title":"Bone."},{"issue":"5446","key":"bib16-20210131","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science."},{"issue":"3","key":"bib17-20210131","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0006-291X(03)01408-6","article-title":"Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells","volume":"308","author":"Song","year":"2003","journal-title":"Biochem Biophys Res Commun."},{"issue":"4","key":"bib18-20210131","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00774-010-0231-y","article-title":"Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ER\u03b1 expression and uterine wet weight in ovariectomized rats","volume":"29","author":"Li","year":"2011","journal-title":"J Bone Miner Metab."},{"issue":"3","key":"bib19-20210131","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jor.20572","article-title":"Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing","volume":"27","author":"Patil","year":"2009","journal-title":"J Orthop Res."},{"issue":"2","key":"bib20-20210131","doi-asserted-by":"crossref","first-page":"126","DOI":"10.14310\/horm.2002.1339","article-title":"Statins, bone formation and osteoporosis: hope or hype?","volume":"11","author":"Tsartsalis","year":"2012","journal-title":"Hormones (Athens)."},{"issue":"1","key":"bib21-20210131","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/nsr\/nwu028","article-title":"Novel applications of statins for bone regeneration","volume":"2","author":"Shah","year":"2015","journal-title":"Natl Sci Rev."},{"issue":"1","key":"bib22-20210131","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1472-8206.2004.00299.x","article-title":"Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update","volume":"19","author":"Schachter","year":"2005","journal-title":"Fundam Clin Pharmacol."},{"issue":"37","key":"bib23-20210131","doi-asserted-by":"crossref","first-page":"9373","DOI":"10.1016\/j.biomaterials.2013.08.060","article-title":"Calvarial defect healing by recruitment of autogenous osteogenic stem cells using locally applied simvastatin","volume":"34","author":"Yueyi","year":"2013","journal-title":"Biomaterials."},{"issue":"5","key":"bib24-20210131","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/jbmr.1558","article-title":"Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing","volume":"27","author":"Fukui","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"1","key":"bib25-20210131","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.resuscitation.2011.07.041","article-title":"Pharmacokinetics of intraosseous and central venous drug delivery during cardiopulmonary resuscitation","volume":"83","author":"Hoskins","year":"2012","journal-title":"Resuscitation."},{"issue":"10","key":"bib26-20210131","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1345\/aph.1K168","article-title":"Intraosseous drug administration in children and adults during cardiopulmonary resuscitation","volume":"41","author":"Buck","year":"2007","journal-title":"Ann Pharmacother."},{"issue":"3","key":"bib27-20210131","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/TA.0b013e3181b16f42","article-title":"Proximal humerus intraosseous infusion: a preferred emergency venous access","volume":"67","author":"Paxton","year":"2009","journal-title":"J Trauma."},{"issue":"1","key":"bib28-20210131","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0168-3659(03)00094-4","article-title":"Transdermal delivery of insulin from poloxamer gel: ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers","volume":"89","author":"Pillai","year":"2003","journal-title":"J Control Release."},{"issue":"1-2","key":"bib29-20210131","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijpharm.2015.05.040","article-title":"Characterization of gelation process and drug release profile of thermosensitive liquid lecithin\/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen","volume":"490","author":"Djekic","year":"2015","journal-title":"Int J Pharm."},{"issue":"2","key":"bib30-20210131","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00198-015-3230-y","article-title":"A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin\/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs","volume":"27","author":"Tan","year":"2016","journal-title":"Osteoporos Int."},{"issue":"4","key":"bib31-20210131","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/BRS.0b013e318194878d","article-title":"Pedicle screw surface coatings improve fixation in nonfusion spinal constructs","volume":"34","author":"Upasani","year":"2009","journal-title":"Spine (Phila Pa 1976)."},{"key":"bib32-20210131","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.12659\/MSM.892247","article-title":"Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model","volume":"21","author":"Tan","year":"2015","journal-title":"Med Sci Monit."},{"issue":"2","key":"bib33-20210131","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.spinee.2012.01.014","article-title":"Assessment of pedicle screw pullout strength based on various screw designs and bone densities-an ex vivo biomechanical study","volume":"12","author":"Kim","year":"2012","journal-title":"Spine J."},{"issue":"5","key":"bib34-20210131","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF02556360","article-title":"Bone histomorphometry: proposed system for standardization of nomenclature, symbols, and units","volume":"42","author":"Parfitt","year":"1988","journal-title":"Calcif Tissue Int."},{"issue":"2","key":"bib35-20210131","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ocl.2013.01.008","article-title":"Surgical stabilization of the spine in the osteoporotic patient","volume":"44","author":"Dodwad","year":"2013","journal-title":"Orthop Clin North Am."},{"issue":"8","key":"bib36-20210131","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.clinbiomech.2009.05.002","article-title":"Pullout strength for cannulated pedicle screws with bone cement augmentation in severely osteoporotic bone: influences of radial hole and pilot hole tapping","volume":"24","author":"Chen","year":"2009","journal-title":"Clin Biomech (Bristol, Avon)."},{"key":"bib37-20210131","doi-asserted-by":"crossref","first-page":"748393","DOI":"10.1155\/2014\/748393","article-title":"Designs and techniques that improve the pullout strength of pedicle screws in osteoporotic vertebrae: current status","volume":"2014","author":"Shea","year":"2014","journal-title":"Biomed Res Int."},{"issue":"14","key":"bib38-20210131","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/01.BRS.0000076829.54235.9F","article-title":"Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty","volume":"28","author":"Belkoff","year":"2003","journal-title":"Spine (Phila Pa 1976)."},{"key":"bib39-20210131","doi-asserted-by":"crossref","first-page":"10","DOI":"10.22203\/eCM.v016a02","article-title":"Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study","volume":"16","author":"Stadelmann","year":"2008","journal-title":"Eur Cell Mater."},{"issue":"3","key":"bib40-20210131","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1600-0501.2003.01015.x","article-title":"Simvastatin promotes osteogenesis around titanium implants","volume":"15","author":"Ayukawa","year":"2004","journal-title":"Clin Oral Implants Res."},{"issue":"2","key":"bib41-20210131","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-0501.2008.01630.x","article-title":"Effects of simvastatin on bone healing around titanium implants in osteoporotic rats","volume":"20","author":"Du","year":"2009","journal-title":"Clin Oral Implants Res."},{"issue":"9","key":"bib42-20210131","first-page":"e485","article-title":"The use of simvastatin in bone regeneration","volume":"14","author":"Park","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal."},{"issue":"3","key":"bib43-20210131","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s00774-013-0496-z","article-title":"Local injection of a single dose of simvastatin augments osteoporotic bone mass in ovariectomized rats","volume":"32","author":"Yang","year":"2014","journal-title":"J Bone Miner Metab."},{"issue":"1-2","key":"bib44-20210131","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijpharm.2014.08.023","article-title":"Enhancement in bioavailability of ketorolac tromethamine via intranasal in situ hydrogel based on poloxamer 407 and carrageenan","volume":"474","author":"Li","year":"2014","journal-title":"Int J Pharm."},{"issue":"5","key":"bib45-20210131","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01623352","article-title":"Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)","volume":"4","author":"Jones","year":"1994","journal-title":"Osteoporos Int."},{"issue":"5","key":"bib46-20210131","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S8756-3282(03)00053-X","article-title":"Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats","volume":"32","author":"Uchida","year":"2003","journal-title":"Bone."},{"issue":"6","key":"bib47-20210131","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bone.2011.03.720","article-title":"Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model","volume":"48","author":"He","year":"2011","journal-title":"Bone."},{"issue":"10","key":"bib48-20210131","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00198-005-1840-5","article-title":"Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis","volume":"16","author":"Koh","year":"2005","journal-title":"Osteoporos Int."},{"issue":"2","key":"bib49-20210131","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ajg.2014.430","article-title":"An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study","volume":"110","author":"Duggan","year":"2015","journal-title":"Am J Gastroenterol."},{"issue":"10","key":"bib50-20210131","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/S0142-9612(01)00350-7","article-title":"22 week assessment of bladder acellular matrix as a bladder augmentation material in a porcine model","volume":"23","author":"Brown","year":"2002","journal-title":"Biomaterials."},{"issue":"1","key":"bib51-20210131","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2015.04.006","article-title":"Dietary soy isoflavones differentially regulate expression of the lipid-metabolic genes in different white adipose tissues of the female Bama mini-pigs","volume":"461","author":"Jiang","year":"2015","journal-title":"Biochem Biophys Res Commun."},{"key":"bib52-20210131","doi-asserted-by":"crossref","first-page":"20620","DOI":"10.1038\/srep20620","article-title":"One-step generation of triple gene-targeted pigs using CRISPR\/Cas9 system","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep."},{"issue":"3","key":"bib53-20210131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/8756-3282(93)90167-9","article-title":"Calcium-restricted ovariectomized Sinclair S-1 minipigs: an animal model of osteopenia and trabecular plate perforation","volume":"14","author":"Mosekilde","year":"1993","journal-title":"Bone."},{"issue":"5","key":"bib54-20210131","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1172\/JCI117901","article-title":"Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study","volume":"95","author":"Lafage","year":"1995","journal-title":"J Clin Invest."},{"issue":"5","key":"bib55-20210131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s001980050161","article-title":"Importance of preclinical studies in the development of drugs for treatment of osteoporosis: a review related to the 1998 WHO guidelines","volume":"9","author":"Bonjour","year":"1999","journal-title":"Osteoporos Int."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004623-201611160-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:37:11Z","timestamp":1787751431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004623-201611160-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":55,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.15.00937","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}