{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:30:55Z","timestamp":1787754655548,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While innovation drives advancement, it is not immune to failure. Previously, we reported a corrosion-related revision rate of 28% (23 of 81 total hip arthroplasties) among patients who received the Rejuvenate modular-neck stem implant with short-term follow-up. Because we observed a dramatic interval failure rate after our initial report, we undertook this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We prospectively followed a cohort of patients who had undergone implantation of the Rejuvenate modular-neck stem, as previously reported. At a minimum of 3 years of follow-up (range, 3.0 to 5.5 years), 73 hips in 63 patients (90% of the original group) were available for analysis. The mean serum cobalt and chromium ion levels were obtained preoperatively and postoperatively. Elevated serum cobalt ion levels (&gt;4 \u03bcg\/L), pain, or abnormal magnetic resonance imaging (MRI) findings were indications for revision surgery. Patient factors and serum metal ion levels were correlated to revision surgery. Additionally, post-revision serum cobalt and chromium ion level trends were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>An 86% clinical failure rate (63 of the 73 hips) was observed at a mean follow-up of 4.2 \u00b1 0.6 years (range, 3.0 to 5.5 years); 57 (78%) of the hips underwent revision at a mean of 3.2 \u00b1 1.0 years (range, 1.0 to 5.5 years), and 6 (8%) of the hips were scheduled for revision. Patients who underwent revision surgery were younger and had greater serum metal ion levels and greater pain compared with patients who did not undergo revision. An elevated serum cobalt ion level was the most important independent factor associated with revision surgery. Cobalt ion levels decreased sharply after revision; however, some patients demonstrated persistent elevation with more gradual decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Emphasizing the reporting of positive results may leave orthopaedic surgeons reticent to publicize negative results; however, the high failure rate of this implant design within 5 years prompted this report. We believe that patients and orthopaedic surgeons should be made aware of this implant\u2019s clinical problems and patients should be followed closely. Expedient revision is necessary when failure is identified, to minimize potentially severe tissue damage and metal toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.15.01082","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T15:32:59Z","timestamp":1466004779000},"page":"e49","source":"Crossref","is-referenced-by-count":33,"title":["Eighty-six Percent Failure Rate of a Modular-Neck Femoral Stem Design at 3 to 5 Years"],"prefix":"10.2106","volume":"98","author":[{"given":"Derek T.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery (D.T.B., M.M., and S.J.I.) and Institute for Academic Medicine (J.P.), Houston Methodist Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Meftah","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (D.T.B., M.M., and S.J.I.) and Institute for Academic Medicine (J.P.), Houston Methodist Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Paranilam","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (D.T.B., M.M., and S.J.I.) and Institute for Academic Medicine (J.P.), Houston Methodist Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Incavo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (D.T.B., M.M., and S.J.I.) and Institute for Academic Medicine (J.P.), Houston Methodist Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"bib1-20230714","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2106\/JBJS.M.00979","article-title":"Early corrosion-related failure of the Rejuvenate modular total hip replacement","volume":"96","author":"Meftah","year":"2014","journal-title":"J Bone Joint Surg Am."},{"issue":"9","key":"bib2-20230714","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3928\/01477447-20100722-30","article-title":"The proximal modular neck in THA: a bridge too far: affirms","volume":"33","author":"Dunbar","year":"2010","journal-title":"Orthopedics."},{"issue":"7","key":"bib3-20230714","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.arth.2008.09.009","article-title":"Corrosion of a hip stem with a modular neck taper junction: a retrieval study of 16 cases","volume":"24","author":"Kop","year":"2009","journal-title":"J Arthroplasty."},{"issue":"7","key":"bib4-20230714","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s11999-011-2155-9","article-title":"Proximal component modularity in THA\u2014at what cost? 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