{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:05Z","timestamp":1790487605058,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"\n Background:<\/jats:title>\n Viscosupplementation has been widely used for the treatment of knee osteoarthritis. Because we found no well-controlled trial comparing single-injection regimens of hyaluronan for knee osteoarthritis, we compared the efficacy and safety of a single intra-articular injection of a novel cross-linked hyaluronan (HYA-JOINT Plus) with a single injection of Synvisc-One in patients with knee osteoarthritis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In a prospective, randomized, controlled, double-blind trial with a 6-month follow-up, 132 patients with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) were randomized to receive 1 intra-articular injection of 3 mL of HYA-JOINT Plus (20 mg\/mL) (n = 66) or 6 mL of Synvisc-One (8 mg\/mL) (n = 66). The primary outcome was the change from baseline in the visual analog scale (VAS) (0 to 100 mm) pain score at 6 months. Secondary outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, Likert scale), Lequesne index, timed \u201cUp & Go\u201d (TUG) test, single-limb stance (SLS) test, use of rescue analgesics, and patient satisfaction.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 121 patients were available for the intention-to-treat analysis at 6 months. Both groups had a significant improvement in the VAS, WOMAC, and Lequesne index scores at each follow-up visit (p < 0.001). Patients who received HYA-JOINT Plus experienced a significantly greater improvement in the VAS pain score at 1, 3, and 6 months compared with those treated with Synvisc-One (adjusted mean difference: \u221212.0, \u22128.5, and \u22126.6; p = 0.001, 0.033, and 0.045, respectively). There were no significant between-group differences in any of the secondary outcomes except the WOMAC stiffness scores at 6 months, which favored HYA-JOINT Plus treatment (p = 0.043). The TUG time did not change significantly in either group during the study (p > 0.05), but the SLS time improved significantly in both the HYA-JOINT Plus and the Synvisc-One group (p = 0.004 and p = 0.022, respectively). No significant between-group differences were observed with respect to patient satisfaction or consumption of analgesics. No serious adverse events occurred following the injections.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n A single injection of either HYA-JOINT Plus or Synvisc-One is safe and effective for 6 months in patients with knee osteoarthritis. HYA-JOINT Plus is superior to Synvisc-One in terms of reducing the VAS pain score at 1, 3, and 6 months and the WOMAC stiffness score at 6 months, with similar safety.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence:<\/jats:title>\n \n Therapeutic\n Level I<\/jats:underline>\n . See Instructions for Authors for a complete description of levels of evidence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2106\/jbjs.16.00469","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T09:20:20Z","timestamp":1489569620000},"page":"462-471","source":"Crossref","is-referenced-by-count":47,"title":["Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis"],"prefix":"10.2106","volume":"99","author":[{"given":"Shu-Fen","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation (S.-F.S., I-H.L., Y.-H.C., and C.-L.H.) and Department of Internal Medicine (C.-W.H.), Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan"},{"name":"National Yang-Ming University School of Medicine, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation (S.-F.S., I-H.L., Y.-H.C., and C.-L.H.) and Department of Internal Medicine (C.-W.H.), Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan"},{"name":"National Yang-Ming University School of Medicine, Taipei City, Taiwan"},{"name":"School of Nursing, Fooyin University, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey-Shyan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing, Fooyin University, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsiu","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation (S.-F.S., I-H.L., Y.-H.C., and C.-L.H.) and Department of Internal Medicine (C.-W.H.), Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation (S.-F.S., I-H.L., Y.-H.C., and C.-L.H.) and Department of Internal Medicine (C.-W.H.), Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation (S.-F.S., I-H.L., Y.-H.C., and C.-L.H.) and Department of Internal Medicine (C.-W.H.), Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"bib2-20230714","first-page":"99","article-title":"The double-blind test of sodium hyaluronate (ARTZ) on osteoarthritis 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Safety"],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.16.00469","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]}}}