{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:15Z","timestamp":1787755515006,"version":"build-2784847793"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2018,1,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aseptic loosening, the most common indication for revision surgery in total hip arthroplasty, can result from osteolysis caused by polyethylene (PE) wear particles. PE wear is increased by age-related oxidation of PE and free radicals emerging during irradiation cross-linking. Diffusion of vitamin E into PE stabilizes free radicals to maintain the biomechanical properties of PE. The purpose of this study was to determine whether vitamin E-infused highly cross-linked PE cups could reduce wear rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a prospective randomized controlled trial, in which 62 patients were allocated to 2 groups: a study group that received a vitamin E-infused highly cross-linked PE (HXLPE\/VitE) cup and a control group that received an ultra-high molecular weight PE (UHMWPE) cup. Using radiostereometric analysis, we measured the penetration of the femoral head into the cup 7 days after surgery (baseline) and then again at 6 months and at 1, 2, and 3 years later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline variables did not differ significantly between the groups. At 1, 2, and 3 years after surgery, the HXLPE\/VitE cup showed significantly less cumulative penetration (creep and wear) than the UHMWPE cup (p = 0.004, p &lt; 0.0001, and p &lt; 0.0001, respectively). The cumulative penetration after 3 years was 0.200 mm for the HXLPE\/VitE cup versus 0.317 mm for the UHMWPE cup (p &lt; 0.0001). From 1 to 3 years after surgery, after creep had stabilized and further penetration was mainly due to wear, the mean penetration increased only 0.04 mm in the HXLPE\/VitE cup and 0.116 mm in the UHMWPE cup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results confirm that wear rates over the first 3 years following surgery were lower in HXLPE\/VitE cups than in UHMWPE cups. This suggests that HXLPE\/VitE cups may prevent osteolysis, implant loosening, and eventually revision surgery. Long-term follow-up data continue to be collected to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level I<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.16.01379","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T17:22:55Z","timestamp":1516296175000},"page":"107-114","source":"Crossref","is-referenced-by-count":38,"title":["Creep and Wear in Vitamin E-Infused Highly Cross-Linked Polyethylene Cups for Total Hip Arthroplasty"],"prefix":"10.2106","volume":"100","author":[{"given":"G.","family":"Rochcongar","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Buia","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bourroux","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dunet","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chapus","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-6141","authenticated-orcid":false,"given":"C.","family":"Hulet","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Caen University Hospital, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"7","key":"bib1-20230901","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2106\/00004623-198567070-00011","article-title":"Results of revision for mechanical failure after cemented total hip replacement, 1979 to 1982. 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