{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:22:51Z","timestamp":1789878171961,"version":"4.0.1"},"reference-count":98,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2018,6,6]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u27a4 Skeletal dysplasias are caused by mutations in genes that encode the collagen molecule family, including collagen type I, collagen type II, and collagen type IX.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a4 These entities, including osteogenesis imperfecta and Ehlers-Danlos syndrome, among others, are characterized by brittle bones, disorganized growth plates, and alterations of linear growth.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a4 Current treatments include pharmacological agents, including bisphosphonates, and surgical modalities such as spinal fusions and fracture fixation with intramedullary rods.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a4 Other treatments including cell and gene-based therapies remain in the experimental stages.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.17.01136","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T14:30:53Z","timestamp":1528295453000},"page":"976-986","source":"Crossref","is-referenced-by-count":7,"title":["The Molecular Basis of Genetic Collagen Disorders and Its Clinical Relevance"],"prefix":"10.2106","volume":"100","author":[{"given":"Antonia","family":"Chen","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Fertala","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Abboud","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wang","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 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