{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:33:14Z","timestamp":1792477994477,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Femoral morphology may influence the etiology of slipped capital femoral epiphysis (SCFE). We investigated whether radiographic parameters of femoral head-neck morphology are associated with a subsequent contralateral slip in patients presenting with unilateral SCFE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We evaluated 318 patients treated for unilateral SCFE between 2000 and 2017. There were 145 males (46%), and the mean age in the series was 12.4 \u00b1 1.7 years. The patients were followed for a minimum of 18 months or until the development of a contralateral slip (70 patients, 22%). We measured the epiphyseal tilt, epiphyseal extension ratio, alpha angle, and epiphyseal angle of the uninvolved, contralateral hip at initial presentation. Multivariable logistic regression analysis was used to assess whether femoral measurements were associated with the occurrence of a contralateral slip. Receiver operating characteristic (ROC) curves were used to determine optimal thresholds of radiographic measures to determine an increased risk of a contralateral slip. A number-needed-to-treat (NNT) analysis was conducted to evaluate the effectiveness of the femoral measurement thresholds in preventing a contralateral slip.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Multivariable analysis, controlling for triradiate cartilage status, identified the lateral tilt angle and the superior epiphyseal extension ratio as independent factors associated with the likelihood of a contralateral slip. For each additional degree of posterior tilt, the odds of a contralateral slip increase by 8% (odds ratio [OR] = 1.08; 95% confidence interval [CI] = 1.02 to 1.14; p = 0.008), and for each 0.01 increase in the superior epiphyseal extension ratio, the odds of a contralateral slip decrease by 6% (OR = 0.94; 95% CI = 0.88 to 0.99; p = 0.03). A threshold for the epiphyseal tilt of 10\u00b0 corresponded to a predicted probability of a contralateral slip of 54% in patients with open triradiate cartilage and an NNT of 3.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients presenting with unilateral SCFE, a higher posterior tilt of the epiphysis increases the risk while an increased superior extension of the epiphysis reduces the risk of a contralateral slip. Our findings may assist the discussion about contralateral prophylactic pinning in patients with unilateral SCFE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Prognostic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.18.00440","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T04:49:00Z","timestamp":1549514940000},"page":"209-217","source":"Crossref","is-referenced-by-count":37,"title":["Predicting Risk of Contralateral Slip in Unilateral Slipped Capital Femoral Epiphysis"],"prefix":"10.2106","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3893-0292","authenticated-orcid":false,"given":"Daniel A.","family":"Maranho","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-6423","authenticated-orcid":false,"given":"Mariana G.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-8996","authenticated-orcid":false,"given":"Young-Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-717X","authenticated-orcid":false,"given":"Patricia E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-3100","authenticated-orcid":false,"given":"Eduardo N.","family":"Novais","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"issue":"2","key":"bib1-20230810","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1302\/0301-620X.70B2.3346283","article-title":"Bilaterality in slipped upper femoral epiphysis","volume":"70","author":"H\u00e4gglund","year":"1988","journal-title":"J Bone Joint Surg Br."},{"issue":"2","key":"bib2-20230810","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/01202412-199605020-00005","article-title":"Bilaterality in slipped capital femoral epiphysis: importance of a reliable radiographic method","volume":"5","author":"Jerre","year":"1996","journal-title":"J Pediatr Orthop B."},{"issue":"8","key":"bib3-20230810","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2106\/00004623-199308000-00003","article-title":"The epidemiology of bilateral slipped capital femoral epiphysis. A study of children in Michigan","volume":"75","author":"Loder","year":"1993","journal-title":"J Bone Joint Surg Am."},{"issue":"2","key":"bib4-20230810","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2106\/00004623-199602000-00009","article-title":"Slipped capital femoral epiphysis. The prevalence of late contralateral slip","volume":"78","author":"Hurley","year":"1996","journal-title":"J Bone Joint Surg Am."},{"key":"bib5-20230810","article-title":"Capital femoral epiphyseal extension may confer physeal stability in slipped capital femoral epiphysis","author":"Morris","year":"2016","journal-title":"J Pediatr Orthop."},{"issue":"3","key":"bib6-20230810","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/BPO.0b013e3182471eb4","article-title":"Prediction of contralateral slipped capital femoral epiphysis using the modified Oxford bone age score","volume":"32","author":"Popejoy","year":"2012","journal-title":"J Pediatr Orthop."},{"issue":"3","key":"bib7-20230810","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2106\/JBJS.F.01027","article-title":"Chondrolysis, osteonecrosis, and slip severity in patients with subsequent contralateral slipped capital femoral epiphysis","volume":"90","author":"Yildirim","year":"2008","journal-title":"J Bone Joint Surg Am."},{"issue":"3","key":"bib8-20230810","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11832-016-0731-y","article-title":"Association between body mass index-for-age and slipped capital femoral epiphysis: the long-term risk for subsequent slip in patients followed until physeal closure","volume":"10","author":"Aversano","year":"2016","journal-title":"J Child Orthop."},{"issue":"3","key":"bib9-20230810","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11832-013-0493-8","article-title":"Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: a systematic review of the literature","volume":"7","author":"Witbreuk","year":"2013","journal-title":"J Child Orthop."},{"issue":"4","key":"bib10-20230810","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/01.bpo.0000158811.29602.a5","article-title":"Posterior sloping angle of the capital femoral physis: a predictor of bilaterality in slipped capital 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