{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:35:33Z","timestamp":1787754933929,"version":"build-2784847793"},"reference-count":93,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,18]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u27a4 Necrotizing fasciitis hijacks the acute phase response, increasing the risk of developing pathophysiologic states commonly associated with death: sepsis-induced coagulopathy (SIC), systemic inflammatory response syndrome (SIRS), and adrenal insufficiency, referred to as critical illness-related corticosteroid insufficiency (CIRCI).<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a4 Dynamic monitoring of SIC, SIRS, and CIRCI may be informative when assessing infection severity and when directing treatment to manage these conditions as soon as they begin to develop.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a4 To reduce the risk of oropharyngeal colonization, N95 respirators should be worn by health-care professionals who are operating on patients with necrotizing fasciitis.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.19.00591","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T14:13:15Z","timestamp":1579875195000},"page":"526-537","source":"Crossref","is-referenced-by-count":36,"title":["Necrotizing Fasciitis: Pillaging the Acute Phase 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