{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:31:49Z","timestamp":1790037109803,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"\n Background:<\/jats:title>\n The use of platelet-rich plasma (PRP) for the treatment of rotator cuff disease is still controversial. The purpose of the present study was to investigate the safety and efficacy of a fully characterized allogeneic pure PRP injection into the subacromial space of patients with rotator cuff disease in comparison with corticosteroid injection.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A 2-group, parallel, assessor-blinded, randomized controlled trial was conducted. A total of 60 patients with clinically and structurally diagnosed rotator cuff disease were randomly assigned to receive a subacromial injection of either 4 mL of allogeneic pure PRP or a 4-mL mixture of 1 mL of 40-mg\/mL triamcinolone acetonide and 3 mL of 2% lidocaine under ultrasonographic guidance. The primary outcomes were safety and the Constant score at 1 month. The secondary outcomes were pain, range of motion, muscle strength, functional scores, and overall satisfaction and function.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n There were no treatment-related adverse events. The Constant score at 1 month did not significantly differ between the PRP and corticosteroid groups. At 6 months, the DASH (Disabilities of the Arm, Shoulder and Hand) score, overall function, and external rotation were significantly better in the PRP group than in the corticosteroid group, and the other clinical outcomes did not show significant differences. All pain measurements, the strength of the supraspinatus and infraspinatus, and 5 functional scores also improved slowly and steadily after injection, becoming significantly better at 6 months compared with those before the injection, whereas those in the corticosteroid group responded promptly but did not further improve.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Allogeneic PRP injections for the treatment of rotator cuff disease are safe but are not definitely superior to corticosteroid injections with respect to pain relief and functional improvement during 6 months. The DASH score, overall function, and external rotation were significantly better in the PRP group than in the steroid group at 6 months. Generally, PRP slowly but steadily reduced pain and improved function of the shoulder until 6 months, whereas corticosteroid did not.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence:<\/jats:title>\n \n Therapeutic\n Level I<\/jats:underline>\n . See Instructions for Authors for a complete description of levels of evidence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2106\/jbjs.19.01411","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T15:12:00Z","timestamp":1602601920000},"page":"2129-2137","source":"Crossref","is-referenced-by-count":54,"title":["Allogeneic Platelet-Rich Plasma Versus Corticosteroid Injection for the Treatment of Rotator Cuff Disease"],"prefix":"10.2106","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-5442","authenticated-orcid":false,"given":"Chris Hyunchul","family":"Jo","sequence":"first","affiliation":[{"name":"Departments of Orthopedic Surgery (C.H.J., S.Y.L., and K.S.Y.), Biostatistics (S.O.), and Laboratory Medicine (S.S.), SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-923X","authenticated-orcid":false,"given":"Seung Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (C.H.J., S.Y.L., and K.S.Y.), Biostatistics (S.O.), and Laboratory Medicine (S.S.), SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5917-1881","authenticated-orcid":false,"given":"Kang Sup","family":"Yoon","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (C.H.J., S.Y.L., and K.S.Y.), Biostatistics (S.O.), and Laboratory Medicine (S.S.), SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-448X","authenticated-orcid":false,"given":"Sohee","family":"Oh","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (C.H.J., S.Y.L., and K.S.Y.), Biostatistics (S.O.), and Laboratory Medicine (S.S.), SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8671","authenticated-orcid":false,"given":"Sue","family":"Shin","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (C.H.J., S.Y.L., and K.S.Y.), Biostatistics (S.O.), and Laboratory Medicine (S.S.), SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"issue":"410","key":"bib1-20230714","first-page":"519","article-title":"Shoulder disorders in general practice: prognostic indicators of outcome","volume":"46","author":"van der Windt","year":"1996","journal-title":"Br J Gen Pract."},{"issue":"1","key":"bib2-20230714","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3961\/jpmph.2013.46.1.39","article-title":"Prevalence of musculoskeletal symptoms related with activities of daily living and contributing factors in Korean adults","volume":"46","author":"Choi","year":"2013","journal-title":"J Prev Med Public Health."},{"issue":"2","key":"bib3-20230714","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/03009740310004667","article-title":"Prevalence and incidence of shoulder pain in the general population; a systematic review","volume":"33","author":"Luime","year":"2004","journal-title":"Scand J Rheumatol."},{"issue":"7525","key":"bib4-20230714","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/bmj.331.7525.1124","article-title":"Shoulder pain: diagnosis and management in primary care","volume":"331","author":"Mitchell","year":"2005","journal-title":"BMJ."},{"issue":"6","key":"bib5-20230714","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/rheumatology\/keh598","article-title":"Diagnosis and relation to general health of shoulder disorders presenting to primary care","volume":"44","author":"Ost\u00f6r","year":"2005","journal-title":"Rheumatology (Oxford)."},{"issue":"7","key":"bib6-20230714","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1007\/s00167-016-4376-7","article-title":"Degree of tendon degeneration and stage of rotator cuff disease","volume":"25","author":"Jo","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"8","key":"bib7-20230714","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/jama.2013.276187","article-title":"Does this patient with shoulder pain have rotator cuff disease?: the rational clinical examination systematic review","volume":"310","author":"Hermans","year":"2013","journal-title":"JAMA."},{"issue":"21","key":"bib8-20230714","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2106\/JBJS.N.01051","article-title":"Treatment of nontraumatic rotator cuff tears: a randomized controlled trial with two years of clinical and imaging follow-up","volume":"97","author":"Kukkonen","year":"2015","journal-title":"J Bone Joint Surg Am."},{"issue":"2","key":"bib9-20230714","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.apmr.2018.06.028","article-title":"Comparative effectiveness of injection therapies in rotator cuff tendinopathy: a systematic review, pairwise and network meta-analysis of randomized controlled trials","volume":"100","author":"Lin","year":"2019","journal-title":"Arch Phys Med Rehabil."},{"issue":"9754","key":"bib10-20230714","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0140-6736(10)61160-9","article-title":"Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials","volume":"376","author":"Coombes","year":"2010","journal-title":"Lancet."},{"issue":"1","key":"bib11-20230714","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40634-018-0145-5","article-title":"Current trends in tendinopathy: consensus of the ESSKA Basic Science Committee. Part II: treatment options","volume":"5","author":"Abat","year":"2018","journal-title":"J Exp Orthop."},{"issue":"1","key":"bib12-20230714","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4055\/cios.2020.12.1.120","article-title":"Proteomic classification and identification of proteins related to tissue healing of platelet-rich plasma","volume":"12","author":"Lee","year":"2020","journal-title":"Clin Orthop Surg."},{"issue":"13","key":"bib13-20230714","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1177\/0363546518800268","article-title":"Allogenic pure platelet-rich plasma therapy for rotator cuff disease: a bench and bed study","volume":"46","author":"Jo","year":"2018","journal-title":"Am J Sports Med."},{"key":"bib14-20230714","doi-asserted-by":"crossref","first-page":"c3037","DOI":"10.1136\/bmj.c3037","article-title":"Exercise therapy after corticosteroid injection for moderate to severe shoulder pain: large pragmatic randomised trial","volume":"340","author":"Crawshaw","year":"2010","journal-title":"BMJ."},{"issue":"2","key":"bib15-20230714","doi-asserted-by":"crossref","first-page":"e000137","DOI":"10.1136\/bmjopen-2011-000137","article-title":"A manual physical therapy approach versus subacromial corticosteroid injection for treatment of shoulder impingement syndrome: a protocol for a randomised clinical trial","volume":"1","author":"Rhon","year":"2011","journal-title":"BMJ Open."},{"issue":"5","key":"bib16-20230714","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0363546516681294","article-title":"Effects of platelet-rich plasma with concomitant use of a corticosteroid on tenocytes from degenerative rotator cuff tears in interleukin 1\u03b2-induced tendinopathic conditions","volume":"45","author":"Jo","year":"2017","journal-title":"Am J Sports Med."},{"issue":"9","key":"bib17-20230714","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1177\/0363546515587081","article-title":"Platelet-rich plasma for arthroscopic repair of medium to large rotator cuff tears: a randomized controlled trial","volume":"43","author":"Jo","year":"2015","journal-title":"Am J Sports Med."},{"issue":"10","key":"bib18-20230714","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1177\/0363546511413454","article-title":"Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study","volume":"39","author":"Jo","year":"2011","journal-title":"Am J Sports Med."},{"issue":"9","key":"bib19-20230714","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/stem.2855","article-title":"Intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial","volume":"36","author":"Jo","year":"2018","journal-title":"Stem Cells."},{"issue":"12","key":"bib20-20230714","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jse.2013.05.002","article-title":"Investigating minimal clinically important difference for Constant score in patients undergoing rotator cuff surgery","volume":"22","author":"Kukkonen","year":"2013","journal-title":"J Shoulder Elbow Surg."},{"issue":"1","key":"bib21-20230714","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1302\/0301-620X.92B1.22137","article-title":"A double-blind randomised controlled study comparing subacromial injection of tenoxicam or methylprednisolone in patients with subacromial impingement","volume":"92","author":"Karthikeyan","year":"2010","journal-title":"J Bone Joint Surg Br."},{"issue":"3","key":"bib22-20230714","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0962280206074463","article-title":"Multiple imputation of discrete and continuous data by fully conditional specification","volume":"16","author":"van Buuren","year":"2007","journal-title":"Stat Methods Med Res."},{"issue":"6","key":"bib23-20230714","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jse.2009.03.021","article-title":"Minimal clinically important differences (MCID) and patient acceptable symptomatic state (PASS) for visual analog scales (VAS) measuring pain in patients treated for rotator cuff disease","volume":"18","author":"Tashjian","year":"2009","journal-title":"J Shoulder Elbow Surg."},{"issue":"5","key":"bib24-20230714","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/art.24396","article-title":"Measuring shoulder function: a systematic review of four questionnaires","volume":"61","author":"Roy","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"1","key":"bib25-20230714","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11999-016-5002-1","article-title":"Corticosteroid injections give small and transient pain relief in rotator cuff tendinosis: a meta-analysis","volume":"475","author":"Mohamadi","year":"2017","journal-title":"Clin Orthop Relat Res."},{"issue":"5","key":"bib26-20230714","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1177\/0363546512437525","article-title":"Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears","volume":"40","author":"Jo","year":"2012","journal-title":"Am J Sports Med."},{"issue":"10","key":"bib27-20230714","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.2106\/00004623-200310000-00008","article-title":"Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor","volume":"85","author":"Wong","year":"2003","journal-title":"J Bone Joint Surg Am."},{"issue":"4","key":"bib28-20230714","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.semarthrit.2013.08.006","article-title":"The risks and benefits of glucocorticoid treatment for tendinopathy: a systematic review of the effects of local glucocorticoid on tendon","volume":"43","author":"Dean","year":"2014","journal-title":"Semin Arthritis Rheum."},{"issue":"1","key":"bib29-20230714","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jor.22193","article-title":"The effects of dexamethasone on human patellar tendon stem cells: implications for dexamethasone treatment of tendon injury","volume":"31","author":"Zhang","year":"2013","journal-title":"J Orthop Res."},{"key":"bib30-20230714","first-page":"CD004016","article-title":"Corticosteroid injections for shoulder pain","volume":"1","author":"Buchbinder","year":"2003","journal-title":"Cochrane Database Syst Rev."},{"issue":"8","key":"bib31-20230714","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/bjsports-2016-097444","article-title":"Are corticosteroid injections more beneficial than anaesthetic injections alone in the management of rotator cuff-related shoulder pain? A systematic review","volume":"52","author":"Cook","year":"2018","journal-title":"Br J Sports Med."},{"issue":"2","key":"bib32-20230714","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jcot.2018.10.014","article-title":"Role of platelet rich plasma in rotator cuff tendinopathy- clinical application and review of literature","volume":"10","author":"Phadke","year":"2019","journal-title":"J Clin Orthop Trauma."},{"issue":"22","key":"bib33-20230714","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1136\/bjsports-2013-093178","article-title":"Glucocorticoids induce specific ion-channel-mediated toxicity in human rotator cuff tendon: a mechanism underpinning the ultimately deleterious effect of steroid injection in tendinopathy?","volume":"48","author":"Dean","year":"2014","journal-title":"Br J Sports Med."},{"issue":"4","key":"bib34-20230714","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12178-018-9527-7","article-title":"Current clinical recommendations for use of platelet-rich plasma","volume":"11","author":"Le","year":"2018","journal-title":"Curr Rev Musculoskelet Med."},{"issue":"7","key":"bib35-20230714","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1007\/s00167-016-4261-4","article-title":"Platelet-rich plasma in tendon-related disorders: results and indications","volume":"26","author":"Filardo","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"5","key":"bib36-20230714","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1016\/j.jse.2007.04.003","article-title":"Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model","volume":"16","author":"W\u00fcrgler-Hauri","year":"2007","journal-title":"J Shoulder Elbow Surg."},{"issue":"12","key":"bib37-20230714","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/bjsports-2013-093281","article-title":"Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review","volume":"48","author":"de Vos","year":"2014","journal-title":"Br J Sports Med."},{"issue":"1","key":"bib38-20230714","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/0363546516643716","article-title":"The effectiveness of platelet-rich plasma in the treatment of tendinopathy: a meta-analysis of randomized controlled clinical trials","volume":"45","author":"Fitzpatrick","year":"2017","journal-title":"Am J Sports Med."},{"issue":"18","key":"bib39-20230714","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/bjsports-2016-096515","article-title":"Effectiveness of conservative interventions including exercise, manual therapy and medical management in adults with shoulder impingement: a systematic review and meta-analysis of RCTs","volume":"51","author":"Steuri","year":"2017","journal-title":"Br J Sports Med."},{"issue":"11","key":"bib40-20230714","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1177\/0363546513496542","article-title":"Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up","volume":"41","author":"Kesikburun","year":"2013","journal-title":"Am J Sports Med."},{"issue":"8","key":"bib41-20230714","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00590-016-1826-3","article-title":"Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears","volume":"26","author":"Shams","year":"2016","journal-title":"Eur J Orthop Surg Traumatol."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.19.01411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:43:33Z","timestamp":1787751813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.19.01411"}},"subtitle":["A Randomized Controlled Trial"],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":41,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.19.01411","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]}}}