{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:28Z","timestamp":1787755348340,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Traditionally defined \u201cmeniscal\u201d and \u201cmechanical\u201d symptoms are thought to arise from meniscal tears. Yet meniscal tears and cartilage damage commonly coexist in symptomatic knees. To better characterize the primary driver of these symptoms, we investigated whether the presence of preoperative patient-reported knee symptoms (PRKS), including knee catching\/locking, grinding\/clicking\/popping, and pain with pivoting, are associated with various intra-articular pathological conditions diagnosed at knee arthroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We collected prospective data from 565 consecutive patients who underwent knee arthroscopy from 2012 to 2019 and had PRKS collected via the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire. The diagnosis of meniscal pathology and concomitant cartilage damage was confirmed and classified intraoperatively. We used multivariable regression models, adjusting for possible confounders, to examine the association of specific pathological conditions of the knee with the presence of preoperative PRKS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Tricompartmental cartilage damage was strongly associated with significantly worse PRKS, with an increase of 0.33 point (95% confidence interval [CI] = 0.08 to 0.58; p = 0.01) on a 0 to 4-point scale. We did not observe an association between meniscal pathology and preoperative PRKS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Contrary to current dogma, this study demonstrates that traditionally defined \u201cmeniscal\u201d and \u201cmechanical\u201d knee symptoms are strongly associated with the burden and severity of underlying cartilage damage rather than with specific meniscal pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.20.01193","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T14:51:19Z","timestamp":1610635879000},"page":"381-388","source":"Crossref","is-referenced-by-count":21,"title":["Meniscal and Mechanical Symptoms Are Associated with Cartilage Damage, Not Meniscal Pathology"],"prefix":"10.2106","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-2955","authenticated-orcid":false,"given":"Evan M.","family":"Farina","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-9167","authenticated-orcid":false,"given":"Natalie A.","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-3755","authenticated-orcid":false,"given":"Yuchiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-9223","authenticated-orcid":false,"given":"Kaetlyn R.","family":"Arant","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-4670","authenticated-orcid":false,"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8592-7187","authenticated-orcid":false,"given":"Elizabeth G.","family":"Matzkin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery (E.M.F., N.A.L., J.N.K., and E.G.M.) and the Orthopedic and Arthritis Center for Outcomes Research (Y.C., K.R.A., and J.N.K.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"11","key":"bib1-20231204","first-page":"1","article-title":"Ambulatory surgery in the United States, 2006","author":"Cullen","year":"2009","journal-title":"Natl Health Stat Report."},{"issue":"9","key":"bib2-20231204","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1177\/0363546517701431","article-title":"Knee arthroscopic surgery in middle-aged patients with 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