{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:28:35Z","timestamp":1790216915873,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anterior vertebral body tethering (aVBT) has emerged as a novel treatment option for patients with idiopathic scoliosis. We present the results from the first U.S. Food and Drug Administration (FDA) Investigational Device Exemption (IDE) study on aVBT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective review of a retrospective data set, eligible patients underwent aVBT at a single center from August 2011 to July 2015. Inclusion criteria included skeletally immature patients with Lenke type-1A or 1B curves between 30\u00b0 and 65\u00b0. Clinical and radiographic parameters were collected, with the latter measured by an independent reviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifty-seven patients (49 girls and 8 boys), with a mean age (and standard deviation) of 12.4 \u00b1 1.3 years (range, 10.1 to 15.0 years), were enrolled in the study. The patients had a mean of 7.5 \u00b1 0.6 levels tethered, the mean operative time was 223 \u00b1 79 minutes, and the mean estimated blood loss was 106 \u00b1 86 mL. The patients were followed for an average of 55.2 \u00b1 12.5 months and had a mean Risser grade of 4.2 \u00b1 0.9 at the time of the latest follow-up. The main thoracic Cobb angle was a mean of 40.4\u00b0 \u00b1 6.8\u00b0 preoperatively and was corrected to 18.7\u00b0 \u00b1 13.4\u00b0 at the most recent follow-up. In the sagittal plane, T5-T12 kyphosis measured 15.5\u00b0 \u00b1 10.0\u00b0 preoperatively, 17.0\u00b0 \u00b1 10.1\u00b0 postoperatively, and 19.6\u00b0 \u00b1 12.7\u00b0 at the most recent follow-up. Eighty percent of patients had curves of &lt;30\u00b0 at the most recent follow-up. The most recent Scoliosis Research Society (SRS) scores averaged 4.5 \u00b1 0.4, and scores on the self-image questionnaire averaged 4.4 \u00b1 0.7. No major neurologic or pulmonary complications occurred. Seven (12.3%) of 57 patients had a revision: 5 were done for overcorrection and 2, for adding-on.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Anterior VBT is a promising technique that has emerged as a treatment option for patients with immature idiopathic scoliosis. We present the results from the first FDA-approved IDE study on aVBT, which formed the basis for the eventual Humanitarian Device Exemption approval. The findings affirm the safety and efficacy of this technique and suggest opportunities for improvement, particularly with respect to reoperation rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.20.01503","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T15:01:14Z","timestamp":1624978874000},"page":"1611-1619","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":79,"title":["Prospective Follow-up Report on Anterior Vertebral Body Tethering for Idiopathic Scoliosis"],"prefix":"10.2106","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4206-610X","authenticated-orcid":false,"given":"Amer F.","family":"Samdani","sequence":"first","affiliation":[{"name":"Shriners Hospitals for Children-Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-354X","authenticated-orcid":false,"given":"Joshua M.","family":"Pahys","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children-Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-0937","authenticated-orcid":false,"given":"Robert J.","family":"Ames","sequence":"additional","affiliation":[{"name":"Lewis Katz School of Medicine at Temple University, Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-9527","authenticated-orcid":false,"given":"Harsh","family":"Grewal","sequence":"additional","affiliation":[{"name":"St. Christopher\u2019s Hospital for Children, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-069X","authenticated-orcid":false,"given":"Glenn J.","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-3683","authenticated-orcid":false,"given":"Steven W.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children-Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-9966","authenticated-orcid":false,"given":"Randal R.","family":"Betz","sequence":"additional","affiliation":[{"name":"Institute for Spine & Scoliosis, Lawrenceville, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"6","key":"bib1-20250430","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2106\/00004623-199506000-00001","article-title":"Effectiveness of treatment with a brace in girls who have adolescent idiopathic scoliosis. 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