{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:48Z","timestamp":1787755608100,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>For elective total joint arthroplasty, tranexamic acid (TXA) is considered safe and efficacious. However, evidence of TXA\u2019s safety in high-risk patients undergoing nonelective surgery for hip fracture is sparse. This study aimed to assess whether TXA administration to high-risk patients with an intertrochanteric (IT) hip fracture increased the risk of thromboembolic complications or mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients treated surgically for IT hip fracture between 2015 and 2019 across 4 hospitals of a single hospital system were considered. High- versus low-risk patients and those receiving TXA versus no TXA treatment were identified. Propensity scores adjusted for risk differences between patient groups with TXA and no TXA administration were calculated for (1) high-risk patients (n = 141) and (2) the entire population (n = 316). Postoperative mortality, deep venous thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI), and stroke within 90 days of surgery were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No association between TXA administration and increased risk of mortality or complications in either group was identified. Specifically, out of 282 matched high-risk patients, no differences in mortality (odds ratio [OR], 0.97 [95% confidence interval (CI), 0.90, 1.05]), DVT (OR, 0.97 [95% CI, 0.93, 1.00]), PE (OR 1.00 [95% CI, 0.95, 1.05]), MI (OR, 1.04 [95% CI, 0.98, 1.10]), or stroke (OR, 1.00 [95% CI, 0.95, 1.05]) were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our review of propensity-matched high-risk patients undergoing surgical repair for IT fracture, we found that TXA administration compared with no TXA administration was not associated with an increased risk of mortality, DVT, PE, MI, or stroke within 90 days of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.21.01389","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T17:00:51Z","timestamp":1656608451000},"page":"1138-1147","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Tranexamic Acid Was Not Associated with Increased Complications in High-Risk Patients with Intertrochanteric Fracture"],"prefix":"10.2106","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-2004","authenticated-orcid":false,"given":"Steven B.","family":"Porter","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-6756","authenticated-orcid":false,"given":"Aaron C.","family":"Spaulding","sequence":"additional","affiliation":[{"name":"Division of Health Care Delivery Research, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-4762","authenticated-orcid":false,"given":"Christopher M.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-6954","authenticated-orcid":false,"given":"Benjamin K.","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1679-0046","authenticated-orcid":false,"given":"Mark W.","family":"Pagnano","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-1724","authenticated-orcid":false,"given":"Matthew P.","family":"Abdel","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"issue":"2","key":"bib1-20250430","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.arth.2014.08.022","article-title":"Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty","volume":"30","author":"Duncan","year":"2015","journal-title":"J Arthroplasty."},{"issue":"20","key":"bib2-20250430","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.2106\/JBJS.21.00172","article-title":"Tranexamic Acid Was Not Associated with Increased Complications in High-Risk Patients with Hip Fracture Undergoing Arthroplasty","volume":"103","author":"Porter","year":"2021","journal-title":"J Bone Joint Surg Am."},{"issue":"1","key":"bib3-20250430","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/rapm-2018-000024","article-title":"Tranexamic acid in total joint arthroplasty: the endorsed clinical practice guides of the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society","volume":"44","author":"Fillingham","year":"2019","journal-title":"Reg Anesth Pain Med."},{"issue":"1","key":"bib4-20250430","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.arth.2019.08.015","article-title":"Tranexamic Acid Administration Is Not Associated With an Increase in Complications in High-Risk Patients Undergoing Primary Total Knee or Total Hip Arthroplasty: A Retrospective Case-Control Study of 38,220 Patients","volume":"35","author":"Porter","year":"2020","journal-title":"J Arthroplasty."},{"issue":"11","key":"bib5-20250430","doi-asserted-by":"crossref","first-page":"e14564","DOI":"10.1097\/MD.0000000000014564","article-title":"Tranexamic acid can reduce blood loss in patients undergoing intertrochanteric fracture surgery: A meta-analysis","volume":"98","author":"Jiang","year":"2019","journal-title":"Medicine (Baltimore)."},{"issue":"1","key":"bib6-20250430","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13018-017-0625-9","article-title":"Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial","volume":"12","author":"Lei","year":"2017","journal-title":"J Orthop Surg Res."},{"issue":"11","key":"bib7-20250430","first-page":"S17","article-title":"Does tranexamic acid reduce blood transfusion following surgery for inter-trochanteric fracture? 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