{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:02:54Z","timestamp":1792612974984,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:sec>\n                    <jats:title>Update<\/jats:title>\n                    <jats:p>This article was updated on December 22, 2023, because of a previous error. Specifically, there was an error in one of the grant numbers mentioned in the article. In the Source of Funding paragraph, the text that had previously read \u201c2022-PUMCH-D-007\u201d now reads \u201c2022-PUMCH-D-004.\u201d<\/jats:p>\n                    <jats:p>An erratum has been published: J Bone Joint Surg Am. 2024 Feb 7;106(3):e8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Congenital scoliosis is frequently associated with anomalies in multiple organ systems. However, the prevalence and distribution of associated anomalies remain unclear, and there is a large amount of variation in data among different studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Six hundred and thirty-six Chinese patients who had undergone scoliosis correction surgery at Peking Union Medical College Hospital from January 2012 to July 2019 were recruited, as a part of the\n                      <jats:underline>D<\/jats:underline>\n                      eciphering disorders\n                      <jats:underline>I<\/jats:underline>\n                      nvolving\n                      <jats:underline>S<\/jats:underline>\n                      coliosis and\n                      <jats:underline>CO<\/jats:underline>\n                      morbidities (DISCO) study. The medical data for each subject were collected and analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age (and standard deviation) at the time of presentation for scoliosis was 6.4 \u00b1 6.3 years, and the mean Cobb angle of the major curve was 60.8\u00b0 \u00b1 26.5\u00b0. Intraspinal abnormalities were found in 186 (30.3%) of 614 patients, with diastematomyelia being the most common anomaly (59.1%; 110 of 186). The prevalence of intraspinal abnormalities was remarkably higher in patients with failure of segmentation and mixed deformities than in patients with failure of formation (p &lt; 0.001). Patients with intraspinal anomalies showed more severe deformities, including larger Cobb angles of the major curve (p &lt; 0.001). We also demonstrated that cardiac anomalies were associated with remarkably worse pulmonary function, i.e., lower forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF). Additionally, we identified associations among different concomitant malformations. We found that patients with musculoskeletal anomalies of types other than intraspinal and maxillofacial were 9.2 times more likely to have additional maxillofacial anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our cohort, comorbidities associated with congenital scoliosis occurred at a rate of 55%. To our knowledge, our study is the first to show that patients with congenital scoliosis and cardiac anomalies have reduced pulmonary function, as demonstrated by lower FEV1, FVC, and PEF. Moreover, the potential associations among concomitant anomalies revealed the importance of a comprehensive preoperative evaluation scheme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Diagnostic\n                      <jats:underline>Level III<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.22.00277","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T14:06:39Z","timestamp":1676469999000},"page":"537-548","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Retrospective Analysis of Associated Anomalies in 636 Patients with Operatively Treated Congenital Scoliosis"],"prefix":"10.2106","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-2889","authenticated-orcid":false,"given":"Nan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of 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Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"},{"name":"Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"},{"name":"Department of Orthopedic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"},{"name":"Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"},{"name":"Department of Orthopedic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of 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